{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360565166757615616.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/ncomms7008"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/ncomms7008.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/ncomms7008"}},{"identifier":{"@type":"PMID","@value":"25613421"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Reprogramming of mouse somatic cells into induced pluripotent stem cells (iPSCs) often generates partially reprogrammed iPSCs (pre-iPSCs), low-grade chimera forming iPSCs (lg-iPSCs) and fully reprogrammed, high-grade chimera production competent iPSCs (hg-iPSCs). Lg-iPSC transcriptome analysis revealed misregulated <jats:italic>Dlk1-Dio3</jats:italic> cluster gene expression and subsequently the imprinting defect at the <jats:italic>Dlk1-Dio3</jats:italic> locus. Here, we show that germ-cell marker <jats:italic>Dppa3</jats:italic> is present only in lg-iPSCs and hg-iPSCs, and that induction with exogenous <jats:italic>Dppa3</jats:italic> enhances reprogramming kinetics, generating all hg-iPSCs, similar to vitamin C (Vc). Conversely, <jats:italic>Dppa3</jats:italic>-null fibroblasts show reprogramming block at pre-iPSCs state and <jats:italic>Dlk1-Dio3</jats:italic> imprinting defect. At the molecular level, we show that Dppa3 is associated with <jats:italic>Dlk1-Dio3</jats:italic> locus and identify that Dppa3 maintains imprinting by antagonizing Dnmt3a binding. Our results further show molecular parallels between Dppa3 and Vc in <jats:italic>Dlk1-Dio3</jats:italic> imprinting maintenance and suggest that early activation of <jats:italic>Dppa3</jats:italic> is one of the cascades through which Vc facilitates the generation of fully reprogrammed iPSCs.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380284919970865795","@type":"Researcher","foaf:name":[{"@value":"Xingbo Xu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919970865799","@type":"Researcher","foaf:name":[{"@value":"Lukasz Smorag"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919970865797","@type":"Researcher","foaf:name":[{"@value":"Toshinobu Nakamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919970865793","@type":"Researcher","foaf:name":[{"@value":"Tohru Kimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919970865802","@type":"Researcher","foaf:name":[{"@value":"Ralf Dressel"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919970865796","@type":"Researcher","foaf:name":[{"@value":"Antje Fitzner"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919970865801","@type":"Researcher","foaf:name":[{"@value":"Xiaoying Tan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919970865800","@type":"Researcher","foaf:name":[{"@value":"Matthias Linke"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919970865794","@type":"Researcher","foaf:name":[{"@value":"Ulrich Zechner"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919970865798","@type":"Researcher","foaf:name":[{"@value":"Wolfgang Engel"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919970865792","@type":"Researcher","foaf:name":[{"@value":"D. V. Krishna Pantakani"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1420282801212781568","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80403202"},{"@type":"NRID","@value":"1000080403202"},{"@type":"NRID","@value":"9000404511210"},{"@type":"NRID","@value":"9000256200654"},{"@type":"NRID","@value":"9000264271644"},{"@type":"NRID","@value":"9000412111041"},{"@type":"NRID","@value":"9000243764419"},{"@type":"NRID","@value":"9000297511623"},{"@type":"NRID","@value":"9000018392308"},{"@type":"NRID","@value":"9000256200546"},{"@type":"NRID","@value":"9000398254004"},{"@type":"NRID","@value":"9000311787524"},{"@type":"NRID","@value":"9000010347143"},{"@type":"NRID","@value":"9000000048382"},{"@type":"NRID","@value":"9000412158557"},{"@type":"NRID","@value":"9000327931331"},{"@type":"NRID","@value":"9000347161412"},{"@type":"NRID","@value":"9000398258459"},{"@type":"NRID","@value":"9000398254394"},{"@type":"NRID","@value":"9000398258498"},{"@type":"NRID","@value":"9000410476538"},{"@type":"NRID","@value":"9000345352353"},{"@type":"NRID","@value":"9000398253363"},{"@type":"NRID","@value":"9000256201001"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/nakamuratoshinobu"}],"foaf:name":[{"@value":"Nakamura, Toshinobu"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801209213312","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50280962"},{"@type":"NRID","@value":"1000050280962"},{"@type":"NRID","@value":"9000411798883"},{"@type":"NRID","@value":"9000018843621"},{"@type":"NRID","@value":"9000001422262"},{"@type":"NRID","@value":"9000238862782"},{"@type":"NRID","@value":"9000238862375"},{"@type":"NRID","@value":"9000238864309"},{"@type":"NRID","@value":"9000238862179"},{"@type":"NRID","@value":"9000238863247"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0191258"}],"foaf:name":[{"@value":"Kimura, Tohru"}]},{"@id":"https://cir.nii.ac.jp/crid/1891709542619356819","@type":"Researcher","foaf:name":[{"@value":"Dressel, Ralf"}]},{"@id":"https://cir.nii.ac.jp/crid/1891709542619356801","@type":"Researcher","foaf:name":[{"@value":"Xu, Xingbo"}]},{"@id":"https://cir.nii.ac.jp/crid/1891709542619356802","@type":"Researcher","foaf:name":[{"@value":"Smorag, Lukasz"}]},{"@id":"https://cir.nii.ac.jp/crid/1891709542619356820","@type":"Researcher","foaf:name":[{"@value":"Fitzner, Antje"}]},{"@id":"https://cir.nii.ac.jp/crid/1891709542619356804","@type":"Researcher","foaf:name":[{"@value":"Tan, Xiaoying"}]},{"@id":"https://cir.nii.ac.jp/crid/1891709542619356818","@type":"Researcher","foaf:name":[{"@value":"Linke, Matthias"}]},{"@id":"https://cir.nii.ac.jp/crid/1891709542619356821","@type":"Researcher","foaf:name":[{"@value":"Zechner, Ulrich"}]},{"@id":"https://cir.nii.ac.jp/crid/1891709542619356808","@type":"Researcher","foaf:name":[{"@value":"Engel, Wolfgang"}]},{"@id":"https://cir.nii.ac.jp/crid/1891709542619356806","@type":"Researcher","foaf:name":[{"@value":"Pantakani, D.V. Krishna"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2015-01-23","prism:volume":"6","prism:number":"1","prism:startingPage":"6008"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","invited":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/ncomms7008.pdf"},{"@id":"https://www.nature.com/articles/ncomms7008"}],"createdAt":"2015-01-23","modifiedAt":"2023-01-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Chromosomal%20Proteins,%20Non-Histone","dc:title":"Chromosomal Proteins, Non-Histone"},{"@id":"https://cir.nii.ac.jp/all?q=Green%20Fluorescent%20Proteins","dc:title":"Green Fluorescent Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Induced%20Pluripotent%20Stem%20Cells","dc:title":"Induced Pluripotent Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Transgenic","dc:title":"Mice, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=Ascorbic%20Acid","dc:title":"Ascorbic Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Iodide%20Peroxidase","dc:title":"Iodide Peroxidase"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Genomic%20Imprinting","dc:title":"Genomic Imprinting"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Crosses,%20Genetic","dc:title":"Crosses, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Profiling","dc:title":"Gene Expression Profiling"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium-Binding%20Proteins","dc:title":"Calcium-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Methylation","dc:title":"DNA Methylation"},{"@id":"https://cir.nii.ac.jp/all?q=Fibroblasts","dc:title":"Fibroblasts"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Repressor%20Proteins","dc:title":"Repressor Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Kinetics","dc:title":"Kinetics"},{"@id":"https://cir.nii.ac.jp/all?q=Germ%20Cells","dc:title":"Germ Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Retroviridae","dc:title":"Retroviridae"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Intercellular%20Signaling%20Peptides%20and%20Proteins","dc:title":"Intercellular Signaling Peptides and Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein Binding"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782235051264","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25112006"},{"@type":"JGN","@value":"JP25112006"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-25112006/"}],"notation":[{"@language":"ja","@value":"着床前胚のエピゲノムダイナミクスと制御"},{"@language":"en","@value":"Epigenome dynamics and regulation in preimplantation embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782311352064","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26640063"},{"@type":"JGN","@value":"JP26640063"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26640063/"}],"notation":[{"@language":"ja","@value":"受精卵におけるタンパク質ノックダウン法の開発"},{"@language":"en","@value":"Development of protein knockdown method in zygote"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257176649216","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24390097"},{"@type":"JGN","@value":"JP24390097"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390097/"}],"notation":[{"@language":"ja","@value":"生殖細胞と多能性幹細胞の相互転換機構"},{"@language":"en","@value":"Reciprocal conversion between germ cells and pluripotent stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257211805312","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25112001"},{"@type":"JGN","@value":"JP25112001"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-25112001/"}],"notation":[{"@language":"ja","@value":"生殖細胞のエピゲノムダイナミクスとその制御"},{"@language":"en","@value":"Regulation of epigenome dynamics and regulation in germ cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257221454848","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25291053"},{"@type":"JGN","@value":"JP25291053"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25291053/"}],"notation":[{"@language":"ja","@value":"全能性細胞に高発現する遺伝子群の解析とその応用"},{"@language":"en","@value":"Analysis and application of totipotent-cell specific genes"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050564285690822016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors."},{"@value":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblasts cultures by defined factors"},{"@value":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblasts by defined factors"},{"@value":"Induction of pluripotent stem cells from mouse embryonic, adult fibroblast cultures by defined factors"},{"@value":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors [Journal Article]"},{"@value":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblastic cultures by defined factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144186449536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618719442176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparative methylation profiles and telomerase biology of mouse multipotent adult germline stem cells and embryonic stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619157229568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MicroRNA signature in various cell types of mouse spermatogenesis: Evidence for stage‐specifically expressed miRNA‐221, ‐203 and ‐34b‐5p mediated spermatogenesis regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621369316608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An ICE pattern crystallizes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643863530624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"In vivo partial cellular reprogramming enhances liver plasticity and regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166751883904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166752149760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094588612352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096020641408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579812090566912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pramef12 enhances reprogramming into naïve iPS cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360845538917134720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dnmt3L and the Establishment of Maternal Genomic Imprints"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656931249792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of maintenance DNA methylation by Stella"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569029159808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570312257408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Methylation Dynamics of Imprinted Genes in Mouse Germ Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043434237184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A recurrent intragenic genomic duplication, other novel mutations in NLRP7 and imprinting defects in recurrent biparental hydatidiform moles"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043692950016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Germline Mutation in NLRP2 (NALP2) in a Familial Imprinting Disorder (Beckwith-Wiedemann Syndrome)"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045655437312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genomic imprinting in germ cells: imprints are under control"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045764861312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045810125184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046166859392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993830080768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Piece of cake"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468618493440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dnmt3a and Dnmt1 functionally cooperate during <i>de novo</i> methylation of DNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470505531392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of the Murine Reprogramming Factors in the Induction of Pluripotency"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943674940032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of the Imprinted Dlk1-Dio3 Region Correlates with Pluripotency Levels of Mouse Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945887239040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prospects for pluripotent stem cell therapies: Into the clinic and back to the bench"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419686091520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421226041344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global and gene-specific histone modification profiles of mouse multipotent adult germline stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894755668352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895346993920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ontogeny of allele-specific methylation associated with imprinted genes in the mouse."}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896259744768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global epigenetic changes during somatic cell reprogramming to iPS cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369693703040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370308975488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Imprinting and the Epigenetic Asymmetry Between Parental Genomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371161254016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PGC7/Stella protects against DNA demethylation in early embryogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844346547072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"stella Is a Maternal Effect Gene Required for Normal Early Development in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845057524992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all–iPS cell mice from terminally differentiated B cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845959622016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stage-Specific Germ-Cell Marker Genes Are Expressed in All Mouse Pluripotent Cell Types and Emerge Early during Induced Pluripotency"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320577674112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320618128256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Testis-Specific Factor CTCFL Cooperates with the Protein Methyltransferase PRMT7 in H19 Imprinting Control Region Methylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793937983360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270212331008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270836028288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetics and the germline"}]},{"@id":"https://cir.nii.ac.jp/crid/1520853832202913792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Germline-specific expression of the Oct-4/green fluorescent plotein(GFP)transgene in mice"},{"@language":"ja-Kana","@value":"Germline-specific expression of the Oct-4 green fluorescent plotein GFP transgene in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650908211456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors"},{"@value":"Induction of pluripotent stem cells from adult human fibroblasts by defined factor"},{"@value":"Induction of pluripotent stem cells from adult human fibroblast by defined factors"},{"@value":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors [in English]"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026350381312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Generation of germline-competent induced pluripotent stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1884242817673788672","@type":"Dataset","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Faculty Opinions recommendation of Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/ncomms7008"},{"@type":"KAKEN","@value":"PRODUCT-14919664"},{"@type":"KAKEN","@value":"PRODUCT-15282601"},{"@type":"KAKEN","@value":"PRODUCT-14571060"},{"@type":"KAKEN","@value":"PRODUCT-14919421"},{"@type":"KAKEN","@value":"PRODUCT-14993809"},{"@type":"OPENAIRE","@value":"doi_dedup___::3126dc8b56ddb06dfbf1ba81c74809ac"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2022.110730_references_DOI_DtgtnIPef1gJF4oEndpk7jG66c7"},{"@type":"CROSSREF","@value":"10.1016/j.bbrep.2022.101267_references_DOI_DtgtnIPef1gJF4oEndpk7jG66c7"}]}