{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360565166759952512.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/ng.3535"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/ng.3535.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/ng.3535"}},{"identifier":{"@type":"PMID","@value":"27898077"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults"}],"description":[{"notation":[{"@value":"The oncogenic mechanisms underlying acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA; 15-39 years old) remain largely elusive. Here we have searched for new oncogenes in AYA-ALL by performing RNA-seq analysis of Philadelphia chromosome (Ph)-negative AYA-ALL specimens (n = 73) with the use of a next-generation sequencer. Interestingly, insertion of D4Z4 repeats containing the DUX4 gene into the IGH locus was frequently identified in B cell AYA-ALL, leading to a high level of expression of DUX4 protein with an aberrant C terminus. A transplantation assay in mice demonstrated that expression of DUX4-IGH in pro-B cells was capable of generating B cell leukemia in vivo. DUX4 fusions were preferentially detected in the AYA generation. Our data thus show that DUX4 can become an oncogenic driver as a result of somatic chromosomal rearrangements and that AYA-ALL may be a clinical entity distinct from ALL at other ages."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380003444996898068","@type":"Researcher","foaf:name":[{"@value":"Takahiko Yasuda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898067","@type":"Researcher","foaf:name":[{"@value":"Shinobu Tsuzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898057","@type":"Researcher","foaf:name":[{"@value":"Masahito Kawazu"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276172882432","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30402580"},{"@type":"NRID","@value":"1000030402580"},{"@type":"NRID","@value":"9000339140665"},{"@type":"NRID","@value":"9000002026329"},{"@type":"NRID","@value":"9000409297222"},{"@type":"NRID","@value":"9000411811844"},{"@type":"NRID","@value":"9000409846925"},{"@type":"NRID","@value":"9000000684286"},{"@type":"NRID","@value":"9000413692617"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0156659"}],"foaf:name":[{"@value":"Fumihiko Hayakawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898066","@type":"Researcher","foaf:name":[{"@value":"Shinya Kojima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898073","@type":"Researcher","foaf:name":[{"@value":"Toshihide Ueno"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898070","@type":"Researcher","foaf:name":[{"@value":"Naoto Imoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326227539456","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00627119"},{"@type":"NRID","@value":"1000000627119"},{"@type":"NRID","@value":"9000410487263"},{"@type":"NRID","@value":"9000240112002"},{"@type":"NRID","@value":"9000019242677"},{"@type":"NRID","@value":"9000410744825"},{"@type":"NRID","@value":"9000399162360"},{"@type":"NRID","@value":"9000361685431"},{"@type":"NRID","@value":"9000272241614"},{"@type":"NRID","@value":"9000403271617"},{"@type":"NRID","@value":"9000337097666"},{"@type":"NRID","@value":"9000238038297"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/shinji_kohsaka"}],"foaf:name":[{"@value":"Shinji Kohsaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276175368064","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50608768"},{"@type":"NRID","@value":"1000050608768"},{"@type":"NRID","@value":"9000412524383"},{"@type":"NRID","@value":"9000410651609"},{"@type":"NRID","@value":"9000413236483"},{"@type":"NRID","@value":"9000014160128"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kunitaa"}],"foaf:name":[{"@value":"Akiko Kunita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898049","@type":"Researcher","foaf:name":[{"@value":"Koichiro Doi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898055","@type":"Researcher","foaf:name":[{"@value":"Toru Sakura"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801190460928","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80346551"},{"@type":"NRID","@value":"1000080346551"},{"@type":"NRID","@value":"9000001289401"},{"@type":"NRID","@value":"9000404106597"},{"@type":"NRID","@value":"9000257943930"},{"@type":"NRID","@value":"9000258727997"},{"@type":"NRID","@value":"9000391595094"},{"@type":"NRID","@value":"9000415198914"},{"@type":"NRID","@value":"9000258036980"},{"@type":"NRID","@value":"9000411811846"},{"@type":"NRID","@value":"9000399374128"},{"@type":"NRID","@value":"9000258042533"},{"@type":"NRID","@value":"9000415202951"},{"@type":"NRID","@value":"9000004078267"},{"@type":"NRID","@value":"9000313607710"},{"@type":"NRID","@value":"9000298899239"},{"@type":"NRID","@value":"9000411801513"},{"@type":"NRID","@value":"9000257873352"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0119189"}],"foaf:name":[{"@value":"Toshiaki Yujiri"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898071","@type":"Researcher","foaf:name":[{"@value":"Eisei Kondo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898060","@type":"Researcher","foaf:name":[{"@value":"Katsumichi Fujimaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898056","@type":"Researcher","foaf:name":[{"@value":"Yasunori Ueda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898059","@type":"Researcher","foaf:name":[{"@value":"Yasutaka Aoyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898053","@type":"Researcher","foaf:name":[{"@value":"Shigeki Ohtake"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801181688704","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00359621"},{"@type":"NRID","@value":"1000000359621"},{"@type":"ORCID","@value":"0000-0002-2452-6520"},{"@type":"NRID","@value":"9000406229976"},{"@type":"NRID","@value":"9000364866745"},{"@type":"NRID","@value":"9000326637947"},{"@type":"NRID","@value":"9000018652489"},{"@type":"NRID","@value":"9000411073337"},{"@type":"NRID","@value":"9000410487489"},{"@type":"NRID","@value":"9000402444752"},{"@type":"NRID","@value":"9000413535625"},{"@type":"NRID","@value":"9000414337544"},{"@type":"NRID","@value":"9000405107513"},{"@type":"NRID","@value":"9000018652914"},{"@type":"NRID","@value":"9000364845189"},{"@type":"NRID","@value":"9000414253859"},{"@type":"NRID","@value":"9000406229965"},{"@type":"NRID","@value":"9000412524764"},{"@type":"NRID","@value":"9000413927028"},{"@type":"NRID","@value":"9000409505533"},{"@type":"NRID","@value":"9000264271471"},{"@type":"NRID","@value":"9000298901353"},{"@type":"NRID","@value":"9000405107487"},{"@type":"NRID","@value":"9000014160914"},{"@type":"NRID","@value":"9000408577443"},{"@type":"NRID","@value":"9000405107475"},{"@type":"NRID","@value":"9000404657999"},{"@type":"NRID","@value":"9000410492891"},{"@type":"NRID","@value":"9000364871291"},{"@type":"NRID","@value":"9000329427063"},{"@type":"NRID","@value":"9000334735606"},{"@type":"NRID","@value":"9000242743880"},{"@type":"NRID","@value":"9000412182671"},{"@type":"NRID","@value":"9000364871177"},{"@type":"NRID","@value":"9000399539718"},{"@type":"NRID","@value":"9000409630231"},{"@type":"NRID","@value":"9000275827055"},{"@type":"NRID","@value":"9000364902381"},{"@type":"NRID","@value":"9000413515063"},{"@type":"NRID","@value":"9000364907103"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/jt-kyoto"}],"foaf:name":[{"@value":"Junko Takita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898064","@type":"Researcher","foaf:name":[{"@value":"Eirin Sai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898074","@type":"Researcher","foaf:name":[{"@value":"Masafumi Taniwaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898052","@type":"Researcher","foaf:name":[{"@value":"Mineo Kurokawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898069","@type":"Researcher","foaf:name":[{"@value":"Shinichi Morishita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898054","@type":"Researcher","foaf:name":[{"@value":"Masashi Fukayama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898062","@type":"Researcher","foaf:name":[{"@value":"Hitoshi Kiyoi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898058","@type":"Researcher","foaf:name":[{"@value":"Yasushi Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898065","@type":"Researcher","foaf:name":[{"@value":"Tomoki Naoe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444996898061","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Mano"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10614036"},{"@type":"EISSN","@value":"15461718"}],"prism:publicationName":[{"@value":"Nature Genetics"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2016-03-28","prism:volume":"48","prism:number":"5","prism:startingPage":"569","prism:endingPage":"574"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm","http://www.springer.com/tdm"],"url":[{"@id":"http://www.nature.com/articles/ng.3535.pdf"},{"@id":"http://www.nature.com/articles/ng.3535"}],"createdAt":"2016-03-28","modifiedAt":"2023-05-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Adolescent","dc:title":"Adolescent"},{"@id":"https://cir.nii.ac.jp/all?q=Oncogene%20Proteins,%20Fusion","dc:title":"Oncogene Proteins, Fusion"},{"@id":"https://cir.nii.ac.jp/all?q=Cohort%20Studies","dc:title":"Cohort Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Young%20Adult","dc:title":"Young Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Neoplasm","dc:title":"RNA, Neoplasm"},{"@id":"https://cir.nii.ac.jp/all?q=Child","dc:title":"Child"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Homeodomain%20Proteins","dc:title":"Homeodomain Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=MEF2%20Transcription%20Factors","dc:title":"MEF2 Transcription Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Sequence%20Analysis,%20RNA","dc:title":"Sequence Analysis, RNA"},{"@id":"https://cir.nii.ac.jp/all?q=Age%20Factors","dc:title":"Age Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Infant,%20Newborn","dc:title":"Infant, Newborn"},{"@id":"https://cir.nii.ac.jp/all?q=Infant","dc:title":"Infant"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Precursor%20Cell%20Lymphoblastic%20Leukemia-Lymphoma","dc:title":"Precursor Cell Lymphoblastic Leukemia-Lymphoma"},{"@id":"https://cir.nii.ac.jp/all?q=HEK293%20Cells","dc:title":"HEK293 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Child,%20Preschool","dc:title":"Child, Preschool"},{"@id":"https://cir.nii.ac.jp/all?q=NIH%203T3%20Cells","dc:title":"NIH 3T3 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Trans-Activators","dc:title":"Trans-Activators"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Fusion","dc:title":"Gene Fusion"},{"@id":"https://cir.nii.ac.jp/all?q=Immunoglobulin%20Heavy%20Chains","dc:title":"Immunoglobulin Heavy Chains"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781896503808","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16H02676"},{"@type":"JGN","@value":"JP16H02676"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H02676/"}],"notation":[{"@language":"ja","@value":"骨軟部腫瘍における診断マーカーの同定と腫瘍概念の再構築を目指した融合遺伝子の探索"},{"@language":"en","@value":"Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781915592448","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K09856"},{"@type":"JGN","@value":"JP16K09856"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09856/"}],"notation":[{"@language":"ja","@value":"難治性リンパ腫におけるMYC, PVT1再構成・発現の解析と臨床応用"},{"@language":"en","@value":"Molecular cytogenetic studies of MYC and PVT1 rearrangements in refractory and relapsed lymphoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782289396608","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26293242"},{"@type":"JGN","@value":"JP26293242"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293242/"}],"notation":[{"@language":"ja","@value":"小児固形腫瘍の転移・再発を制御するクローン進化の時空的かつ網羅的ゲノム解析"},{"@language":"en","@value":"Comprehensive and spationtemporal genetic analyses of clonal evolution of metastatic and recurrent pediatric solid tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782303714048","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26461421"},{"@type":"JGN","@value":"JP26461421"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461421/"}],"notation":[{"@language":"ja","@value":"白血病発症に関与する時計遺伝子の解明と革新的治療の開発"},{"@language":"en","@value":"Analysis of the role of circadian clock gene in leukemogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782312805376","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26670493"},{"@type":"JGN","@value":"JP26670493"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670493/"}],"notation":[{"@language":"ja","@value":"包括的ゲノムスキャンニングによる小児がんと先天奇形症候群の新規治療戦略の開発"},{"@language":"en","@value":"Development of novel therapies for childhood cancers and congenital anomaly syndromes using integrated genetic scanning"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256827810944","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K09472"},{"@type":"JGN","@value":"JP15K09472"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09472/"}],"notation":[{"@language":"ja","@value":"患者由来腫瘍細胞を用いたスクリーニングによるPh陽性ALL治療薬の探索"},{"@language":"en","@value":"Screening of therapeutic agent for Ph-positive ALL using patient-derived xenograft cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257236662016","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25461432"},{"@type":"JGN","@value":"JP25461432"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461432/"}],"notation":[{"@language":"ja","@value":"血液腫瘍におけるPVT1再構成と相手遺伝子の分子細胞遺伝学的解析ならびに臨床応用"},{"@language":"en","@value":"Molecular-cytogenetic studies of PVT1 rearrangements in hematological malignancies"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257250199808","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25860289"},{"@type":"JGN","@value":"JP25860289"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860289/"}],"notation":[{"@language":"ja","@value":"大腸がんリンパ節転移決定因子であるbuddingの分子機構解明"},{"@language":"en","@value":"Molecular mechanism of budding formation in colon cancer metastasis."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202656215808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"A novel recurrent EP300–ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1050005822298712192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218683611264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>CIC-DUX4</i>\n                    Induces Small Round Cell Sarcomas Distinct from Ewing Sarcoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235489699200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A double‐edged sword: The world according to <i>Capicua</i> in cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142453464704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142906259840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144733697280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146449093760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multiple Protein Domains Contribute to Nuclear Import and Cell Toxicity of DUX4, a Candidate Pathogenic Protein for Facioscapulohumeral Muscular Dystrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168776584320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cancer in adolescents and young adults in Japan: epidemiology and cancer strategy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013245146099200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017280648725120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinical characteristics and outcomes of B-cell precursor ALL with MEF2D rearrangements: a retrospective study by the Ponte di Legno Childhood ALL Working Group"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017280653597056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oncogenic lesions and molecular subtypes in adults with B‐cell acute lymphoblastic leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017280653608320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Functional inhibition of MEF2 by C/EBP is a possible mechanism of leukemia development by <i>CEBP‐IGH</i> fusion gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390754629632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CIC-Rearranged Sarcoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708413006464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Erratum: Corrigendum: Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617526156928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617885118592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinical utility of target capture‐based panel sequencing in hematological malignancies: A multicenter feasibility study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345009373952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Feasibility and clinical utility of comprehensive genomic profiling of hematological malignancies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306906080596352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NUP98‐BPTF promotes oncogenic transformation through PIM1 upregulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180261130368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TEL (ETV6)-AML1 (RUNX1) Initiates Self-Renewing Fetal Pro-B Cells in Association with a Transcriptional Program Shared with Embryonic Stem Cells in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183918358016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185766155776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Treatment and biology of pediatric acute lymphoblastic leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092502590848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"High prevalence of\n                    <scp>\n                      <i>MEF2D</i>\n                    </scp>\n                    fusion in human B‐cell precursor acute lymphoblastic leukemia cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092861400192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinical characteristics and outcomes of B-ALL with ZNF384 rearrangements: a retrospective analysis by the Ponte di Legno Childhood ALL Working Group"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093828944256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of a novel fusion gene in a pre‐B acute lymphoblastic leukemia with t(1;19)(q23;p13)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380594522368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>RGS1</i> and <i>CREB5</i> are direct and common transcriptional targets of <scp>ZNF384</scp>‐fusion proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658390219008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569872789120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>IGH</i>\n                    @ Translocations Are Prevalent in Teenagers and Young Adults With Acute Lymphoblastic Leukemia and Are Associated With a Poor Outcome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593723512448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of <i>CDX2</i> and <i>IDH1/2</i> mutations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593808545280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Acquisition of a rare <i>NUP98–BPTF</i> fusion gene associated with recurrence of acute myeloid leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861704789455744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"EBF1–JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705582470528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Improvements in allogeneic hematopoietic cell transplantation outcomes for adults with ALL over the past 3 decades"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815499303040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Promoter swapping of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131414275230976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<scp>ZNF</scp>384‐fusion proteins have high affinity for the transcriptional coactivator <scp>EP</scp>300 and aberrant transcriptional activities"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044009450880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518427531392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519319504000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Restraining the V(D)J recombinase"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521244659072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular transformation of NIH3T3 fibroblasts by CIZ/NMP4 fusions"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995843576192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evolutionary Conservation of a Coding Function for D4Z4, the Tandem DNA Repeat Mutated in Facioscapulohumeral Muscular Dystrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471159608448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"FSHD: copy number variations on the theme of muscular dystrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943492939648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943766971520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acute Lymphoblastic Leukemia in Adolescents and Young Adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945863558272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946274973824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418367101568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Facioscapulohumeral Dystrophy: Incomplete Suppression of a Retrotransposed Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418745506432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The RIN: an RNA integrity number for assigning integrity values to RNA measurements"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419358002048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893524752640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844158225536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320373415680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795676486272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Malignant hematologic diseases in adolescents and young adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270956205696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>DUX4</i>\n            , a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of\n            <i>PITX1</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680521741824","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Targeting mRNA for the treatment of facioscapulohumeral muscular dystrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681427255424","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"1. Leukemia in the AYA Generation and the Role of the Internal Medicine"},{"@language":"ja","@value":"1．AYA世代の白血病と内科の役割"},{"@value":"AYA世代の白血病と内科の役割"},{"@language":"ja-Kana","@value":"AYA セダイ ノ ハッケツビョウ ト ナイカ ノ ヤクワリ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/ng.3535"},{"@type":"KAKEN","@value":"PRODUCT-20790893"},{"@type":"KAKEN","@value":"PRODUCT-21237775"},{"@type":"KAKEN","@value":"PRODUCT-21031515"},{"@type":"KAKEN","@value":"PRODUCT-21086014"},{"@type":"KAKEN","@value":"PRODUCT-20571053"},{"@type":"KAKEN","@value":"PRODUCT-21186703"},{"@type":"KAKEN","@value":"PRODUCT-20199665"},{"@type":"KAKEN","@value":"PRODUCT-20541966"},{"@type":"KAKEN","@value":"PRODUCT-20582121"},{"@type":"OPENAIRE","@value":"doi_dedup___::94513d338f022c290fe0e3e4b09d506d"},{"@type":"CROSSREF","@value":"10.1111/cas.13413_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1158/2643-3230.bcd-19-0080_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1182/bloodadvances.2019001307_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1007/s10147-021-02064-x_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1073/pnas.2120787119_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1038/s41375-022-01737-4_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1111/cas.15583_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1111/cas.15641_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1111/cas.15427_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1016/j.path.2023.06.003_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1038/ng1216-1587a_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.5582/irdr.2016.01056_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1016/j.biopha.2020.110330_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1111/cas.14552_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.2169/naika.106.1883_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1182/blood.2021011921_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1002/cam4.7445_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1073/pnas.1814397115_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1111/ped.13457_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1002/hon.2762_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1038/s41375-021-01199-0_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1002/cam4.7471_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1038/s41388-018-0573-9_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1002/pbc.29201_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1007/s12185-023-03585-z_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1182/bloodadvances.2022008032_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1038/s41698-023-00485-7_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1002/1873-3468.13506_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"},{"@type":"CROSSREF","@value":"10.1158/0008-5472.can-16-3351_references_DOI_VmS5l7NM3N28Alhju1X9Wn1JVRu"}]}