{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360565170745727872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3892/ijo.2016.3710"}},{"identifier":{"@type":"URI","@value":"https://spandidos-publications.com/10.3892/ijo.2016.3710/download"}},{"identifier":{"@type":"PMID","@value":"27826621"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review)"}],"description":[{"notation":[{"@value":"Due to the key role in various cellular processes including cell proliferation and cell survival on many cell types, dysregulation of the PI3K/AKT pathway represents a crucial step of the pathogenesis in many diseases. Furthermore, the tumor suppressor PTEN negatively regulates the PI3K/AKT pathway through its lipid phosphatase activity, which is recognized as one of the most frequently deleted and/or mutated genes in human cancer. Given the pervasive involvement of this pathway, the development of the molecules that modulate this PI3K/AKT signaling has been initiated in studies which focus on the extensive effective drug discovery. Consequently, the PI3K/AKT pathway appears to be an attractive pharmacological target both for cancer therapy and for neurological protection necessary after the therapy. A better understanding of the molecular relations could reveal new targets for treatment development. We review recent studies on the features of PI3K/AKT and PTEN, and their pleiotropic functions relevant to the signaling pathways involved in cancer progress and in neuronal damage by the therapy."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658337619202","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50242110"},{"@type":"NRID","@value":"1000050242110"},{"@type":"NRID","@value":"9000403272108"},{"@type":"NRID","@value":"9000347086823"},{"@type":"NRID","@value":"9000005710583"},{"@type":"NRID","@value":"9000005789250"},{"@type":"NRID","@value":"9000391805989"},{"@type":"NRID","@value":"9000391805993"},{"@type":"NRID","@value":"9000010014912"},{"@type":"NRID","@value":"9000004682463"},{"@type":"NRID","@value":"9000019005162"},{"@type":"NRID","@value":"9000391804290"},{"@type":"NRID","@value":"9000005708559"},{"@type":"NRID","@value":"9000403572420"},{"@type":"NRID","@value":"9000283529821"},{"@type":"NRID","@value":"9000403272093"},{"@type":"NRID","@value":"9000004704090"},{"@type":"NRID","@value":"9000411545880"},{"@type":"NRID","@value":"9000391809438"},{"@type":"NRID","@value":"9000391797485"},{"@type":"NRID","@value":"9000000171579"},{"@type":"NRID","@value":"9000391800853"},{"@type":"NRID","@value":"9000241653005"},{"@type":"NRID","@value":"9000391805881"},{"@type":"NRID","@value":"9000391797557"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0158673"}],"foaf:name":[{"@value":"Satoru Matsuda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003449269108096","@type":"Researcher","foaf:name":[{"@value":"Mayuko Ichimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003449269108099","@type":"Researcher","foaf:name":[{"@value":"Mako Ogino"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003449269108097","@type":"Researcher","foaf:name":[{"@value":"Noriko Nakano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003449269108101","@type":"Researcher","foaf:name":[{"@value":"Akari Minami"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003449269108100","@type":"Researcher","foaf:name":[{"@value":"Toshiyuki Murai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003449269108098","@type":"Researcher","foaf:name":[{"@value":"Yasuko Kitagishi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10196439"},{"@type":"EISSN","@value":"17912423"}],"prism:publicationName":[{"@value":"International Journal of Oncology"}],"dc:publisher":[{"@value":"Spandidos Publications"}],"prism:publicationDate":"2016-09-27","prism:volume":"49","prism:number":"5","prism:startingPage":"1785","prism:endingPage":"1790"},"reviewed":"false","url":[{"@id":"https://spandidos-publications.com/10.3892/ijo.2016.3710/download"}],"createdAt":"2016-09-27","modifiedAt":"2019-09-14","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Brain%20Diseases","dc:title":"Brain Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Combined%20Modality%20Therapy","dc:title":"Combined Modality Therapy"},{"@id":"https://cir.nii.ac.jp/all?q=Neuroprotection","dc:title":"Neuroprotection"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms","dc:title":"Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Targeted%20Therapy","dc:title":"Molecular Targeted Therapy"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Kinase%20Inhibitors","dc:title":"Protein Kinase Inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphoinositide-3%20Kinase%20Inhibitors","dc:title":"Phosphoinositide-3 Kinase Inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256774930304","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"14J12035"},{"@type":"JGN","@value":"JP14J12035"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14J12035/"}],"notation":[{"@language":"ja","@value":"食品成分による免疫細胞のエピジェネティック変化"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257168985216","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24240098"},{"@type":"JGN","@value":"JP24240098"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24240098/"}],"notation":[{"@language":"ja","@value":"ＤＮＡ修復分子群のエピジェネティック解析と食健康"},{"@language":"en","@value":"Interaction of DNA repair epigenetics and 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