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Anti-diabetic drug metformin dilates retinal blood vessels through activation of AMP-activated protein kinase in rats
Bibliographic Information
- Published
- 2017-03
- Resource Type
- journal article
- Rights Information
-
- https://www.elsevier.com/tdm/userlicense/1.0/
- DOI
-
- 10.1016/j.ejphar.2017.01.003
- Publisher
- Elsevier BV
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Description
The aim of this study was to examine whether metformin, a biguanide anti-hyperglycemic drug, dilates retinal blood vessels in rats. Ocular fundus images were captured with an original high-resolution digital fundus camera in vivo and diameters of retinal blood vessels were measured. Both systemic blood pressure and heart rate were continuously recorded. Metformin (0.01-0.3mg/kg/min) increased diameters of retinal blood vessels in a dose-dependent manner. This retinal vasodilator effect of metformin was abolished by compound C, an inhibitor of AMP-activated protein kinase (AMPK), and N
Journal
-
- European Journal of Pharmacology
-
European Journal of Pharmacology 798 66-71, 2017-03
Elsevier BV
