{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360567183200727296.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/np100795d"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/np100795d"}},{"identifier":{"@type":"PMID","@value":"21341753"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Structures, Synthesis, and Human Nod1 Stimulation of Immunostimulatory Bacterial Peptidoglycan Fragments in the Environment"}],"description":[{"notation":[{"@value":"Bacteria release immunostimulatory compounds to the environment, and one of the stimulants is the ligand of nucleotide-binding oligomerization domain protein 1 (Nod1), an intracellular protein involved in the recognition of the bacterial component peptidoglycans having a diaminopimelic acid (DAP) structure. The polymorphisms of Nod1 have been linked to several inflammatory diseases and allergies that are strongly affected by environmental factors. The present paper summarizes recent results on the isolation and structural elucidation of natural human Nod1 (hNod1) ligands from the Escherichia coli (E. coli) K-12 culture supernatant, the first chemical synthesis of these natural ligands and related PGN fragments structures, and the hNod1 stimulatory activities of the chemically synthesized DAP-type PGN fragments. For structural characterization studies, the 7-(diethylamino)coumarin-3-carbonyl (DEAC) labeling method was also used to enhance the sensitivity in mass spectrometry studies, in order to observe PGN fragments in a comprehensive manner. The results suggest that DAP-containing bacteria release certain hNod1 ligands to the environment and that these ligands accumulate in the environment and regulate the immune system through Nod1."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326204999040","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00362616"},{"@type":"NRID","@value":"1000000362616"},{"@type":"NRID","@value":"9000006764407"},{"@type":"NRID","@value":"9000383838834"},{"@type":"NRID","@value":"9000006709221"},{"@type":"NRID","@value":"9000256026958"},{"@type":"NRID","@value":"9000242565786"},{"@type":"NRID","@value":"9000396141388"},{"@type":"NRID","@value":"9000257738181"},{"@type":"NRID","@value":"9000404530380"},{"@type":"NRID","@value":"9000413773626"},{"@type":"NRID","@value":"9000404852024"},{"@type":"NRID","@value":"9000260215455"},{"@type":"NRID","@value":"9000258733671"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read_0118566"}],"foaf:name":[{"@value":"Yukari Fujimoto"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326235681152","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80192722"},{"@type":"NRID","@value":"1000080192722"},{"@type":"NRID","@value":"9000021782546"},{"@type":"NRID","@value":"9000253073817"},{"@type":"NRID","@value":"9000256026962"},{"@type":"NRID","@value":"9000256020200"},{"@type":"NRID","@value":"9000256018585"},{"@type":"NRID","@value":"9000242565785"},{"@type":"NRID","@value":"9000311788303"},{"@type":"NRID","@value":"9000406221776"},{"@type":"NRID","@value":"9000256016071"},{"@type":"NRID","@value":"9000002162633"},{"@type":"NRID","@value":"9000021878200"},{"@type":"NRID","@value":"9000404852052"},{"@type":"NRID","@value":"9000256008892"},{"@type":"NRID","@value":"9000257738182"},{"@type":"NRID","@value":"9000021805970"},{"@type":"NRID","@value":"9000256022462"},{"@type":"NRID","@value":"9000257728237"},{"@type":"NRID","@value":"9000409009219"},{"@type":"NRID","@value":"9000404530379"},{"@type":"NRID","@value":"9000256011452"},{"@type":"NRID","@value":"9000006764310"},{"@type":"NRID","@value":"9000020727089"},{"@type":"NRID","@value":"9000021765560"},{"@type":"NRID","@value":"9000411532888"},{"@type":"NRID","@value":"9000283394357"},{"@type":"NRID","@value":"9000019241104"},{"@type":"NRID","@value":"9000403403446"},{"@type":"NRID","@value":"9000255696961"},{"@type":"NRID","@value":"9000002144424"},{"@type":"NRID","@value":"9000406018103"},{"@type":"NRID","@value":"9000001472029"},{"@type":"NRID","@value":"9000021867722"},{"@type":"NRID","@value":"9000353371892"},{"@type":"NRID","@value":"9000397864514"},{"@type":"NRID","@value":"9000403403449"},{"@type":"NRID","@value":"9000256020827"},{"@type":"NRID","@value":"9000260215456"},{"@type":"NRID","@value":"9000021870098"},{"@type":"NRID","@value":"9000410485966"},{"@type":"NRID","@value":"9000258733676"},{"@type":"NRID","@value":"9000408488503"},{"@type":"NRID","@value":"9000256016156"},{"@type":"NRID","@value":"9000256020612"},{"@type":"NRID","@value":"9000257723667"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0076573"}],"foaf:name":[{"@value":"Koichi Fukase"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01633864"},{"@type":"EISSN","@value":"15206025"}],"prism:publicationName":[{"@value":"Journal of Natural Products"}],"dc:publisher":[{"@value":"American Chemical Society (ACS)"}],"prism:publicationDate":"2011-02-22","prism:volume":"74","prism:number":"3","prism:startingPage":"518","prism:endingPage":"525"},"reviewed":"false","url":[{"@id":"https://pubs.acs.org/doi/pdf/10.1021/np100795d"}],"createdAt":"2011-02-22","modifiedAt":"2023-04-16","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Bacteria","dc:title":"Bacteria"},{"@id":"https://cir.nii.ac.jp/all?q=Nod1%20Signaling%20Adaptor%20Protein","dc:title":"Nod1 Signaling Adaptor Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Escherichia%20coli","dc:title":"Escherichia coli"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Peptidoglycan","dc:title":"Peptidoglycan"},{"@id":"https://cir.nii.ac.jp/all?q=Diaminopimelic%20Acid","dc:title":"Diaminopimelic Acid"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782029631232","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20241053"},{"@type":"JGN","@value":"JP20241053"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20241053/"}],"notation":[{"@language":"ja","@value":"糖鎖の化学合成と免疫系・神経系における機能研究"},{"@language":"en","@value":"Chemical synthesis of glycans and glycoconjugates for elucidation of their functions in immune and nerve system"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782107845760","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22310136"},{"@type":"JGN","@value":"JP22310136"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22310136/"}],"notation":[{"@language":"ja","@value":"自然免疫-獲得免疫を制御する細菌由来化合物の化学合成と機能解析"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782143589888","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23241074"},{"@type":"JGN","@value":"JP23241074"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23241074/"}],"notation":[{"@language":"ja","@value":"糖鎖合成と生体イメージングを基盤とする糖鎖の生物機能解析"},{"@language":"en","@value":"Studies on biological function of glycoconjugates using synthetic probes and in vivo imaging"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144206056704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145378661376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis and Proinflammatory Properties of Muramyl Tripeptides Containing Lysine and Diaminopimelic Acid Moieties"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145743996032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis of 2‐Amino‐octa‐4,7‐Dien‐1‐ol (2): Key Intermediate for Mycothiazole Natural Product and Analogs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618699435136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619016810880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"How Bacteria Consume Their Own Exoskeletons (Turnover and Recycling of Cell Wall Peptidoglycan)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619282824704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Asymmetric synthesis of 2,6-diaminopimelic acids"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619850195200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential Release and Distribution of Nod1 and Nod2 Immunostimulatory Molecules among Bacterial Species and Environments"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620161171328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytoplasmic recognition of RNA☆"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620712129920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621174913536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621202162688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Breaching the great wall: peptidoglycan and microbial interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168242857216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"RNA recognition and signal transduction by RIG‐I‐like receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093722497536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Asymmetric synthesis of differentially protected meso-2,6-diaminopimelic acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094206806016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Constitutive Septal Murein Synthesis in\n                    <i>Escherichia coli</i>\n                    with Impaired Activity of the Morphogenetic Proteins RodA and Penicillin-Binding Protein 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094747920384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Siblings, Day-Care Attendance, and the Risk of Asthma and Wheezing during Childhood"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094976089728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096083156224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Modification of the Structure of Peptidoglycan Is a Strategy To Avoid Detection by Nucleotide-Binding Oligomerization Domain Protein 1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641807491200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569211884160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lytic Transglycosylase MltB of <i>Escherichia coli</i> and Its Role in Recycling of Peptidoglycan Strands of Bacterial Cell Wall"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569922241792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association between exposure to farming, allergies and genetic variation in\n                    <i>CARD4</i>\n                    /\n                    <i>NOD1</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570130986496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of <i>CARD15</i> polymorphisms with atopy‐related traits in a population‐based cohort of Caucasian adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570693374080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The C-terminal Domain of Escherichia coli YfhD Functions as a Lytic Transglycosylase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571395421952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043612934272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Detection, isolation, and analysis of a released Bordetella pertussis product toxic to cultured tracheal cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044199447808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis of Lipopolysaccharide, Peptidoglycan, and Lipoteichoic Acid Fragments"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045975830400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthetic study of peptidoglycan partial structures. Synthesis of tetrasaccharide and octasaccharide fragments"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519562901632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519598841344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Conjugate addition of radicals generated from diacyloxyiodobenzenes to dehydroamino acid derivatives; a synthesis of diaminopimelic acid analogues"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993873998080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Photolysis of Diacyl Peroxides:  A Radical-Based Approach for the Synthesis of Functionalized Amino Acids"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994922311040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural Analysis of the Capsular Polysaccharide from <i>Acinetobacter lwoffii</i> F78"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995342643456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural and Immunochemical Analysis of the Lipopolysaccharide from <i>Acinetobacter lwoffii</i> F78 Located Outside <i>Chlamydiaceae</i> with a <i>Chlamydia</i>‐Specific Lipopolysaccharide Epitope"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468687327744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469446028928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A concise, stereoselective synthesis of meso-2,6-diaminopimelic acid (DAP)"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469509242368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Function of Nod‐like receptors in microbial recognition and host defense"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943752766976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944242246400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944323592576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NOD1 variation, immunoglobulin E and asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944442424704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sensitive determination of monoterpene alcohols in urine by HPLC–FLD combined with ESI-MS detection after online-solid phase extraction of the monoterpene-coumarincarbamate derivates"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418492233728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Total Synthesis of <i>N</i>-Acetylglucosamine-1,6-anhydro-<i>N</i>-acetylmuramylpentapeptide and Evaluation of Its Turnover by AmpD from Escherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418630823552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tracheal cytotoxin structural requirements for respiratory epithelial damage in pertussis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418848129280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unusual peptides containing the 2,6-diaminopimelic acid framework: Stereocontrolled synthesis, X-ray analysis, and computational modelling. Part 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419051600512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hay fever and asthma in relation to markers of infection in the United States"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419421613440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis of Diaminopimelic Acid Containing Peptidoglycan Fragments and Tracheal Cytotoxin (TCT) and Investigation of Their Biological Functions"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419929168384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pathogen Recognition and Innate Immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420303553664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Asymmetric synthesis of differentially protected meso-2,6-diaminopimelic acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420668158720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420925701376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A simple asymmetric synthesis of (+)- and (−)-2,6-diaminopimelic acids"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421241441280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893403353088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Relative Scarcity of Asthma and Atopy among Rural Adolescents Raised on a Farm"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893598321664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The synthesis of diaminopimelic acid containing peptidoglycan fragments using metathesis cross coupling"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893709202304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IEIIS Meeting minireview: Chemical synthesis of peptidoglycan fragments for elucidation of the immunostimulating mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894739764096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895882711168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Stereoselective Synthesis of<i>trans</i>-1,2-Disubstituted Alkenes Based on the Condensation of Aldehydes with Metallated 1-Phenyl-1<i>H</i>-tetrazol-5-yl Sulfones"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368923102720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bacterial cell wall recycling provides cytosolic muropeptides as effectors for beta-lactamase induction."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369057417344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enantiomerically Pure α-Amino Acid Synthesis via Hydroboration−Suzuki Cross-Coupling"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369111012992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370071559808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371038724352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of Natural Human Nucleotide-binding Oligomerization Domain Protein 1 (Nod1) Ligands from Bacterial Culture Supernatant for Elucidation of Immune Modulators in the Environment"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843539682816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Role of Lipophilic Peptidoglycan-related Molecules in Induction of Nod1-mediated Immune Responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845077298048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bacterial-Cell-Wall Peptidoglycan Fragments Produced by Phage lamba or Vi II Endolysin and Containing 1,6-Anhydro-N-acetylmuramic Acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845264075648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis of Muramyl Peptides Containing meso-Diaminopimelic Acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845455591552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intracellular pattern recognition receptors in the host response"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845926912640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An asymmetric synthesis of differentially protected meso-2,6-diaminopimelic acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846088094080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Decreased prevalence of asthma among farm-reared children compared with those who are rural but not farm-reared"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846100833792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846121650304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis of peptidoglycan fragments and evaluation of their biological activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318291849216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Asymmetric Synthesis of (2<i>S</i>,6<i>S</i>)- and <i>meso</i>-(2<i>S</i>,6<i>R</i>)-Diaminopimelic Acids from Enantiopure Bis(sulfinimines)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319552605952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320835711232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of NOD1 polymorphisms with atopic eczema and related phenotypes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321095162496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagic control of listeria through intracellular innate immune recognition in drosophila"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793614253440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TLRs and innate immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793946117888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794269277056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stereoselective Synthesis of <i>meso</i>-2,6-Diaminopimelic Acid and Its Selectively Protected Derivatives"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268642992640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Meso</i>-Diaminopimelic Acid and <i>Meso</i>-Lanthionine, Amino Acids Specific to Bacterial Peptidoglycans, Activate Human Epithelial Cells through NOD1"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270700452864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270748124800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A concise, total synthesis of the TMC-95A/B proteasome inhibitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680316829056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis of Bacterial Glycoconjugates and Their Bio-functional Studies in Innate Immunity"},{"@language":"ja","@value":"細菌由来複合糖質の合成と自然免疫研究"},{"@language":"ja-Kana","@value":"サイキン ユライ フクゴウ トウシツ ノ ゴウセイ ト シゼン メンエキ ケンキュウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980076406576640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Toll-like receptors and innate immunity"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1021/np100795d"},{"@type":"KAKEN","@value":"PRODUCT-11951564"},{"@type":"KAKEN","@value":"PRODUCT-13269718"},{"@type":"KAKEN","@value":"PRODUCT-13799347"},{"@type":"OPENAIRE","@value":"doi_dedup___::e7030c5b96bd3c9ceecfc9cc068192e7"},{"@type":"CROSSREF","@value":"10.1039/c2np00091a_references_DOI_SjeQR6ervIkh1bXCZ43Co2kYlB4"},{"@type":"CROSSREF","@value":"10.5059/yukigoseikyokaishi.70.113_references_DOI_SjeQR6ervIkh1bXCZ43Co2kYlB4"}]}