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Evolutionarily conserved BIL4 suppresses the degradation of brassinosteroid receptor BRI1 and regulates cell elongation
Description
<jats:title>Abstract</jats:title><jats:p>Brassinosteroids (BRs), plant steroid hormones, play important roles in plant cell elongation and differentiation. To investigate the mechanisms of BR signaling, we previously used the BR biosynthesis inhibitor Brz as a chemical biology tool and identified the <jats:italic>Brz-insensitive-long hypocotyl4</jats:italic> mutant (<jats:italic>bil4</jats:italic>). Although the <jats:italic>BIL4</jats:italic> gene encodes a seven-transmembrane-domain protein that is evolutionarily conserved in plants and animals, the molecular function of BIL4 in BR signaling has not been elucidated. Here, we demonstrate that BIL4 is expressed in early elongating cells and regulates cell elongation in <jats:italic>Arabidopsis</jats:italic>. BIL4 also activates BR signaling and interacts with the BR receptor brassinosteroid insensitive 1 (BRI1) in endosomes. BIL4 deficiency increases the localization of BRI1 in the vacuoles. Our results demonstrate that BIL4 regulates cell elongation and BR signaling via the regulation of BRI1 localization.</jats:p>
Journal
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- Scientific Reports
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Scientific Reports 7 (1), 5739-, 2017-07-18
Springer Science and Business Media LLC
