{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360567184433718656.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1089/jop.2013.0121"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/full-xml/10.1089/jop.2013.0121"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1089/jop.2013.0121"}},{"identifier":{"@type":"PMID","@value":"24286181"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Effects of Several Anti-Glaucoma Medications on the Circadian Intraocular Pressure Fluctuations in Patients with Primary Open-Angle Glaucoma"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:</jats:title>\n                    <jats:p>The purpose of the present study was to elucidate the effects of several anti-glaucoma medications on the circadian intraocular pressure (IOP) fluctuations in patients with primary open-angle glaucoma (POAG).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:</jats:title>\n                    <jats:p>\n                      POAG patients (\n                      <jats:italic toggle=\"yes\">n</jats:italic>\n                      =61; 61 eyes) with or without glaucoma medications were included. IOP measurement at 14 time points (12, 15, 18, 21, 0, 6, 9, 12, 15, 18, 21, 0, 6, and 9 o'clock) was performed over a period of 48 h. IOP changes occurring in the first 24 h and the subsequent 24 h were evaluated by several therapeutic factors.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:</jats:title>\n                    <jats:p>A nocturnal acrophase pattern was observed in all the eyes with POAG. The shape of the first 24 h IOP curve was similar to that of the following 24 h IOP curves. However, there were fewer overall IOP levels in the second 24 h time period. Circadian IOP fluctuation patterns exhibited in each eye on the 1st and 2nd days were single acrophase patterns: diurnal acrophase (1st day, 54.0%; 2nd day, 60.7%) and nocturnal acrophase (1st day, 36.1%; 2nd day, 31.1%), and no single acrophase patterns: flat (1st day, 6.6%; 2nd day, 4.9%) and double acrophase (1st day, 3.3%; 2nd day, 3.3%). Among the different medication groups, a nocturnal acrophase circadian pattern was observed in the patient groups being treated by combinations of prostaglandin analog (PG) and β blocker or PG, β blocker and carbonic anhydrase inhibitor (CAI). However, this was not apparent in patient groups with or without single anti-glaucoma medications or a combination of PG and CAI.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:</jats:title>\n                    <jats:p>The present study of IOP monitoring patients with POAG over a period of 48 h indicated that their changes in circadian patterns of IOP were affected by types of anti-glaucoma medications.</jats:p>\n                  </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380567184433718659","@type":"Researcher","foaf:name":[{"@value":"Sachie Tanaka"}],"jpcoar:affiliationName":[{"@value":"Sapporo Medical University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184433718658","@type":"Researcher","foaf:name":[{"@value":"Megumi Watanabe"}],"jpcoar:affiliationName":[{"@value":"Sapporo Medical University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184433718662","@type":"Researcher","foaf:name":[{"@value":"Shu-ichiro Inatomi"}],"jpcoar:affiliationName":[{"@value":"Sapporo Medical University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184433718661","@type":"Researcher","foaf:name":[{"@value":"Kazushi Umeda"}],"jpcoar:affiliationName":[{"@value":"Sapporo Medical University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184433718660","@type":"Researcher","foaf:name":[{"@value":"Kaori Yoshida"}],"jpcoar:affiliationName":[{"@value":"Sapporo Medical University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184433718656","@type":"Researcher","foaf:name":[{"@value":"Ikuyo Ohguro"}],"jpcoar:affiliationName":[{"@value":"Sapporo Medical University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751160353792","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30203748"},{"@type":"NRID","@value":"1000030203748"},{"@type":"NRID","@value":"9000244879604"},{"@type":"NRID","@value":"9000413771762"}],"foaf:name":[{"@value":"Hiroshi Ohguro"}],"jpcoar:affiliationName":[{"@value":"Sapporo Medical University School of Medicine"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10807683"},{"@type":"EISSN","@value":"15577732"}],"prism:publicationName":[{"@value":"Journal of Ocular Pharmacology and Therapeutics"}],"dc:publisher":[{"@value":"SAGE 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