{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360567184592811136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/jrr/rrw070"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jrr/article/57/6/684/2605897"}},{"identifier":{"@type":"PMID","@value":"27422932"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Carbon-ion radiotherapy for locally advanced cervical cancer with bladder invasion"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>The purpose of this study was to evaluate the efficacy and toxicities of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical cancer with bladder invasion by a subset analysis of pooled data from eight prospective clinical trials at the National Institute of Radiological Sciences. Between June 1995 and January 2014, 29 patients with locally advanced cervical cancer with bladder invasion were identified. The median age was 56 years old (range 31–79 years old). The median tumor size at diagnosis on magnetic resonance imaging was 6.7 cm (range 3.5–11.0 cm). Histologically, 20 patients had squamous cell carcinoma and 9 had adenocarcinoma. C-ion RT was performed as a dose-escalation study in the initial trials. All patients received prophylactic whole-pelvic or extended-field irradiation and local boost. The total dose to the cervical tumor was 52.8–74.4 Gy (relative biological effectiveness) in 20 or 24 fractions. Weekly cisplatin (40 mg/m2/week, five cycles) was concurrently given to four patients. The median follow-up of all patients was 28.6 months (range 8.8–238.6 months). Grade 2 or higher late complications in the bladder were observed in eight patients, with seven developing vesicovaginal fistula. Six patients had Grade 2 or higher complications in the rectosigmoid colon. The 3-year overall survival rate was 47%, the 3-year local control rate was 66%, and the 3-year disease-free survival rate was 28%. In this study, C-ion RT showed favorable local control with reasonable toxicities, but the results were still unsatisfactory. We have the expectation of improvement of therapeutic effects by using C-ion RT with concurrent chemotherapy.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276180090112","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90826950"},{"@type":"NRID","@value":"1000090826950"},{"@type":"NRID","@value":"9000409764228"},{"@type":"NRID","@value":"9000302392652"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000024805"}],"foaf:name":[{"@value":"Shintaro Shiba"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276185111168","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40399449"},{"@type":"NRID","@value":"1000040399449"},{"@type":"NRID","@value":"9000024128664"},{"@type":"NRID","@value":"9000002971840"},{"@type":"NRID","@value":"9000024131843"},{"@type":"NRID","@value":"9000024135023"},{"@type":"NRID","@value":"9000024138934"},{"@type":"NRID","@value":"9000319068284"},{"@type":"NRID","@value":"9000391984317"},{"@type":"NRID","@value":"9000024128622"},{"@type":"NRID","@value":"9000399834926"},{"@type":"NRID","@value":"9000253500537"},{"@type":"NRID","@value":"9000020964675"}],"foaf:name":[{"@value":"Masaru Wakatsuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184592811151","@type":"Researcher","foaf:name":[{"@value":"Shingo Kato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184592810884","@type":"Researcher","foaf:name":[{"@value":"Tatsuya Ohno"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751146658176","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00750572"},{"@type":"NRID","@value":"1000000750572"},{"@type":"NRID","@value":"9000258732339"},{"@type":"NRID","@value":"9000398631169"},{"@type":"NRID","@value":"9000006957014"},{"@type":"NRID","@value":"9000402923779"},{"@type":"NRID","@value":"9000412017431"},{"@type":"NRID","@value":"9000413526868"},{"@type":"NRID","@value":"9000018182655"},{"@type":"NRID","@value":"9000239848769"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/okonogi"}],"foaf:name":[{"@value":"Noriyuki Okonogi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184592811137","@type":"Researcher","foaf:name":[{"@value":"Kumiko Karasawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184592810885","@type":"Researcher","foaf:name":[{"@value":"Hiroki Kiyohara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184592811139","@type":"Researcher","foaf:name":[{"@value":"Hirohiko Tsujii"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326217963520","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20211427"},{"@type":"NRID","@value":"1000020211427"},{"@type":"NRID","@value":"9000008372293"},{"@type":"NRID","@value":"9000345248181"},{"@type":"NRID","@value":"9000253660909"},{"@type":"NRID","@value":"9000345254115"},{"@type":"NRID","@value":"9000296661868"},{"@type":"NRID","@value":"9000258077655"},{"@type":"NRID","@value":"9000242256718"},{"@type":"NRID","@value":"9000020851722"},{"@type":"NRID","@value":"9000315680707"},{"@type":"NRID","@value":"9000252918208"},{"@type":"NRID","@value":"9000254842819"},{"@type":"NRID","@value":"9000258086236"},{"@type":"NRID","@value":"9000021631496"},{"@type":"NRID","@value":"9000413481434"},{"@type":"NRID","@value":"9000411805689"},{"@type":"NRID","@value":"9000001303710"},{"@type":"NRID","@value":"9000021819373"},{"@type":"NRID","@value":"9000367424004"},{"@type":"NRID","@value":"9000238915299"},{"@type":"NRID","@value":"9000238892951"},{"@type":"NRID","@value":"9000020687563"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0098544"}],"foaf:name":[{"@value":"Takashi Nakano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184592811148","@type":"Researcher","foaf:name":[{"@value":"Tadashi Kamada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567184592811010","@type":"Researcher","foaf:name":[{"@value":"Makio Shozu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"04493060"},{"@type":"EISSN","@value":"13499157"}],"prism:publicationName":[{"@value":"Journal of Radiation Research"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2016-09","prism:volume":"57","prism:number":"6","prism:startingPage":"684","prism:endingPage":"690"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://academic.oup.com/jrr/article/57/6/684/2605897"}],"createdAt":"2016-07-15","modifiedAt":"2020-01-09","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Ions","dc:title":"Ions"},{"@id":"https://cir.nii.ac.jp/all?q=Radiotherapy","dc:title":"Radiotherapy"},{"@id":"https://cir.nii.ac.jp/all?q=Uterine%20Cervical%20Neoplasms","dc:title":"Uterine Cervical Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Radiation","dc:title":"Dose-Response Relationship, Radiation"},{"@id":"https://cir.nii.ac.jp/all?q=Heavy%20Ion%20Radiotherapy","dc:title":"Heavy Ion Radiotherapy"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Carbon","dc:title":"Carbon"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Urinary%20Bladder%20Neoplasms","dc:title":"Urinary Bladder Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Regular%20Paper","dc:title":"Regular Paper"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Prospective%20Studies","dc:title":"Prospective Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256877899392","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16H05388"},{"@type":"JGN","@value":"JP16H05388"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05388/"}],"notation":[{"@language":"ja","@value":"がん重粒子線治療の高度化と治療個別化の為の基礎的・臨床的研究"},{"@language":"en","@value":"Basic and clinical research for advanced cancer heavy ion radiotherapy and individualized treatment"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257295775360","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26861026"},{"@type":"JGN","@value":"JP26861026"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26861026/"}],"notation":[{"@language":"ja","@value":"LETの異なる炭素イオン線と抗癌剤併用時の増感効果の解明"},{"@language":"en","@value":"Synergistic effect carbon-ion irradiation and chemotherapy"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232380518784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evaluation of SCCVII tumor cell survival in clamped and non-clamped solid tumors exposed to carbon-ion beams in comparison to X-rays"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232559838208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dose–escalation study of carbon ion radiotherapy for locally advanced squamous cell carcinoma of the uterine cervix (9902)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234639170432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Difference in distant failure site between locally advanced squamous cell carcinoma and adenocarcinoma of the uterine cervix after C-ion RT"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144095405312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vesicovaginal fistula formation in patients with Stage IVA cervical carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145080093952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European organization for research and treatment of cancer (EORTC)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711795631744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The prognostic value of rectal invasion for stage IVA uterine cervical cancer treated with radiation therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285712546519680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical Trial of Prophylactic Extended-Field Carbon-Ion Radiotherapy for Locally Advanced Uterine Cervical Cancer (Protocol 0508)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180022903808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical outcomes of carbon ion radiotherapy for locally advanced adenocarcinoma of the uterine cervix in phase 1/2 clinical trial (protocol 9704)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095357406336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Can We Predict Vesicovaginal or Rectovaginal Fistula Formation in Patients With Stage IVA Cervical Cancer?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095525561472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Radiation therapy alone for adenocarcinoma of the uterine cervix"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658326649728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phase I/II trial of definitive carbon ion radiotherapy for prostate cancer: evaluation of shortening of treatment period to 3 weeks"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569149458304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Outcome of stage IVA cervical cancer patients with disease limited to the pelvis in the era of chemoradiation: A Gynecologic Oncology Group study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360864117532145664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxygenated and reoxygenated tumors show better local control in radiation therapy for cervical cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520214068096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cervical cancer as a priority for prevention in different world regions: An evaluation using years of life lost"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520989979648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mouse skin reactions following fractionated irradiation with carbon ions"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520994427648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adenocarcinoma of the uterine cervix prognosis and patterns of failure in 367 cases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994421339264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Outcomes of Chemoradiotherapy in Cervical Cancer—The Western Australian Experience"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995090226304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical trial of carbon ion radiotherapy for gynecological melanoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469248755072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparison of prognostic value of MRI and FIGO stage among patients with cervical carcinoma treated with radiotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469342533632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Radiation treatment of FIGO stage IVA carcinoma of the cervix"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469423567744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Carcinoma of the Cervix Uteri"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470324439808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Irradiation of Mixed Beam and Design of Spread-Out Bragg Peak for Heavy-Ion Radiotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944654934656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long‐term results of high‐dose rate intracavitary brachytherapy for squamous cell carcinoma of the uterine cervix"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893631974528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dose escalation study of carbon ion radiotherapy for locally advanced carcinoma of the uterine cervix"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893756086528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A prospective nonrandomized phase I/II study of carbon ion radiotherapy in a favorable subset of locally advanced non–small cell lung cancer (NSCLC)"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895077064704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Carbon Beam Therapy Overcomes the Radiation Resistance of Uterine Cervical Cancer Originating from Hypoxia"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368496651392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phase 1 trial of preoperative, short‐course carbon‐ion radiotherapy for patients with resectable pancreatic cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369555844224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor hypoxia: A target for selective cancer therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843567307776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reduced Oxygen Enhancement Ratio at Low Doses of Ionizing Radiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844698130176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reformulation of a clinical-dose system for carbon-ion radiotherapy treatment planning at the National Institute of Radiological Sciences, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794263398400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The linear-quadratic formula and progress in fractionated radiotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794452312320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Review of Update Clinical Results of Carbon Ion Radiotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796021600512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Radiation therapy alone in the treatment of carcinoma of uterine cervix I. Analysis of tumor recurrence"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269108852736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270495688320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Patient Outcome Study of Concurrent Chemoradiation, External Beam Radiotherapy, and High-Dose Rate Brachytherapy in Locally Advanced Carcinoma of the Cervix"}]},{"@id":"https://cir.nii.ac.jp/crid/1370567184592811019","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The phase I/II clinical study of carbon ion therapy for cancer of the uterine cervix"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1093/jrr/rrw070"},{"@type":"KAKEN","@value":"PRODUCT-20858150"},{"@type":"KAKEN","@value":"PRODUCT-21322465"},{"@type":"OPENAIRE","@value":"doi_dedup___::ec7cbfff0289b7806ebd22e5d16b1206"}]}