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CORRELATIONS BETWEEN EXPERIMENTAL MYOPIA MODELS AND HUMAN PATHOLOGIC MYOPIA
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- Kritchai Vutipongsatorn
- Department of Medicine, Imperial College London, London, United Kingdom;
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- Natsuko Nagaoka
- Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan;
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- Tae Yokoi
- Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan;
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- Takeshi Yoshida
- Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan;
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- Koju Kamoi
- Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan;
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- Shintaro Horie
- Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan;
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- Kengo Uramoto
- Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan;
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- Akira Hirata
- Hayashi Eye Hospital, Fukuoka, Japan;
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- Laurence M. Occelli
- Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan;
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- Simon M. Petersen-Jones
- Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan;
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- Fabiano Montiani-Ferreira
- Department of Veterinary Medicine, Federal University of Paraná, Rua dos Funcionários, Curitiba-PR, Brazil;
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- Olivier Cases
- INSERM UMRS_1138, Centre de Recherche des Cordeliers, Molecular Oral Pathophysiology, Paris, France; and
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- Renata Kozyraki
- INSERM UMRS_1138, Centre de Recherche des Cordeliers, Molecular Oral Pathophysiology, Paris, France; and
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- Jost B. Jonas
- Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
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- Kyoko Ohno-Matsui
- Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan;
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Description
<jats:sec> <jats:title>Purpose:</jats:title> <jats:p>To analyze the hallmark features of pathologic myopia developed in animal models and compare them with those seen in patients.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>A literature review was performed to identify animal models that exhibited key features of pathologic myopia, namely posterior staphyloma, myopic maculopathy, lacquer cracks, and choroidal neovascularization, either spontaneously or induced by monocular deprivation. Using imaging modalities, such as optical coherence tomography, confocal scanning laser ophthalmoscopy, fluorescein angiography, and electron microscopy, these features were compared with those found in myopic maculopathy of patients.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Three types of animals were identified. The LRP2 knockout mice exhibited posterior staphylomas and chorioretinal atrophy at 21 and 60 days after birth, respectively. Retinopathy globe enlarged (<jats:italic toggle="yes">rge</jats:italic>) chicks and normal lid-sutured chicks developed lacquer cracks and chorioretinal atrophy. Lacquer cracks detected in <jats:italic toggle="yes">rge</jats:italic> chicks subsequently progressed to patchy chorioretinal atrophy, which is also commonly seen in patients with pathologic myopia.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>The LRP2 knockout mice, retinopathy globe enlarged (<jats:italic toggle="yes">rge</jats:italic>) chicks, and normal lid-sutured chicks exhibit features typical for myopic maculopathy in patients and could serve to further elucidate the pathogenesis of myopic maculopathy.</jats:p> </jats:sec>
Journal
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- Retina
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Retina 39 (4), 621-635, 2019-04
Ovid Technologies (Wolters Kluwer Health)
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Keywords
- Mice, Knockout
- [SDV.GEN]Life Sciences [q-bio]/Genetics
- Microscopy, Confocal
- [SDV]Life Sciences [q-bio]
- Visual Acuity
- Choroidal Neovascularization
- Scleral Diseases
- Disease Models, Animal
- Microscopy, Electron
- Retinal Diseases
- Myopia, Degenerative
- Animals
- Humans
- Fluorescein Angiography
- Chickens
- Tomography, Optical Coherence
- Dilatation, Pathologic
Details 詳細情報について
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- CRID
- 1360567184844741504
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- ISSN
- 0275004X
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- PubMed
- 30586351
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- Article Type
- journal article
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- Data Source
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- Crossref
- KAKEN
- OpenAIRE