{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360567185478211328.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/hepr.12507"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fhepr.12507"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/hepr.12507"}},{"identifier":{"@type":"PMID","@value":"25692387"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Enhanced survival of mice infused with bone marrow‐derived as compared with adipose‐derived mesenchymal stem cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>Less invasive therapies using mesenchymal stem cells (MSC) are being developed to treat patients with severe liver cirrhosis. MSC constitute a promising cell source for regenerative therapy and are frequently isolated from bone marrow (BMSC) or adipose tissue (ASC). Therefore, this study assessed the characteristics of these two cell types and their safety for cell infusion.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p><jats:italic>In vitro</jats:italic>, exhaustive genetic analysis was performed using human (h)BMSC and hASC. Subsequently, the expression of mRNA and protein was evaluated. <jats:italic>In vivo</jats:italic>, mouse (m)BMSC or mASC was infused into serial mice via the peripheral vein, and 24‐h survival rate, prothrombin time and cause of death were analyzed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>On polymerase chain reaction, western blotting, enzyme‐linked immunoassay and fluorescence‐activated cell sorting, tissue factor was found to be expressed at higher levels in hASC than in hBMSC. Prothrombin time in mice infused with mASC (>120 s) was markedly longer than that of untreated mice (6.5 ± 1.7 s) and that of mice infused with BMSC (6.7 ± 0.8 s) (<jats:italic>P</jats:italic> < 0.001), indicating that pro‐coagulation activity was potently enhanced after ASC infusion. The 24‐h survival rates in the mASC‐ and mBMSC‐infused groups were 46.4% (13/28) and 95.5% (21/22), respectively; in the former, the rate decreased with increasing number of infused mASC. This cell number‐dependent effect was not observed with mBMSC. A histopathological analysis of mice that died immediately following mASC infusion revealed multiple thrombi in the blood vessels of the lungs.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>These results indicate that BMSC are a superior and safer cell source for regenerative therapy.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380567185478211330","@type":"Researcher","foaf:name":[{"@value":"Shogo Shiratsuki"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube 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University Graduate School of Medicine  Ube Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13866346"},{"@type":"EISSN","@value":"1872034X"}],"prism:publicationName":[{"@value":"Hepatology Research"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2015-03-13","prism:volume":"45","prism:number":"13","prism:startingPage":"1353","prism:endingPage":"1359"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fhepr.12507"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/hepr.12507"}],"createdAt":"2015-02-18","modifiedAt":"2023-10-03","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Matrix%20metalloproteinase","dc:title":"Matrix metalloproteinase"},{"@id":"https://cir.nii.ac.jp/all?q=571","dc:title":"571"},{"@id":"https://cir.nii.ac.jp/all?q=Pro-coagulation","dc:title":"Pro-coagulation"},{"@id":"https://cir.nii.ac.jp/all?q=Tissue%20factor","dc:title":"Tissue factor"},{"@id":"https://cir.nii.ac.jp/all?q=Mesenchymal%20stem%20cell","dc:title":"Mesenchymal stem cell"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781850241920","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K09005"},{"@type":"JGN","@value":"JP15K09005"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09005/"}],"notation":[{"@language":"ja","@value":"骨髄由来肝臓修復細胞の同定"},{"@language":"en","@value":"The analysis and identification of bome marrow drived liver repair cell"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782302973440","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26461009"},{"@type":"JGN","@value":"JP26461009"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461009/"}],"notation":[{"@language":"ja","@value":"高機能培養骨髄間葉系幹細胞による高効率な実践的肝臓再生療法の開発研究"},{"@language":"en","@value":"Research and development for liver regeneration therapy with higher-therapeutic effects using the higher-functioning cultured bone marrow mesenchymal stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257189872896","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24590978"},{"@type":"JGN","@value":"JP24590978"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590978/"}],"notation":[{"@language":"ja","@value":"小型骨髄由来肝修復細胞の形態解析と特異因子の探求"},{"@language":"en","@value":"The analysis of small bone marrow drived liver repair 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