{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360567186748242560.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1186/1746-1596-8-147"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1186/1746-1596-8-147.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1186/1746-1596-8-147/fulltext.html"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1186/1746-1596-8-147.pdf"}},{"identifier":{"@type":"PMID","@value":"24034896"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Inflammatory myofibroblastic tumor with RANBP2 and ALKgene rearrangement: a report of two cases and literature review"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n          <jats:p>Inflammatory myofibroblastic tumors (IMTs) are categorized as intermediate biologic neoplasms, whereas IMTs with genetic features of ran-binding protein 2 (<jats:italic>RANBP2</jats:italic>) and anaplastic lymphoma kinase (<jats:italic>ALK</jats:italic>) rearrangement (IMT-RAs) are possibly related to a more aggressive clinical course. However, fewer than 10 cases of IMT-RA have been reported to date. Herein, we present 2 new cases of IMT-RA in which both tumors recurred quickly after primary surgery; one patient died 3 months later from the disease, and the other patient has been living with the disease for 12 months. IMT-RAs are characterized by noncohesive epithelioid and rounded tumoral cell morphology, commonly derived from pelvic and peritoneal cavities, and frequently show larger tumor sizes. The relation between the clinicopathologic features and poor prognosis of IMT-RA is discussed.</jats:p>\n          <jats:p>\n            <jats:bold>Virtual slides</jats:bold>\n          </jats:p>\n          <jats:p>The virtual slide(s) for this article can be found here: <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://www.diagnosticpathology.diagnomx.eu/vs/3314123381007714\" ext-link-type=\"uri\">http://www.diagnosticpathology.diagnomx.eu/vs/3314123381007714</jats:ext-link>\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380567186748242443","@type":"Researcher","foaf:name":[{"@value":"Jian Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567186748242450","@type":"Researcher","foaf:name":[{"@value":"Wei-hua Yin"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801186011904","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40323612"},{"@type":"NRID","@value":"1000040323612"},{"@type":"NRID","@value":"9000261677647"},{"@type":"NRID","@value":"9000263064918"},{"@type":"NRID","@value":"9000258045188"},{"@type":"NRID","@value":"9000018757813"},{"@type":"NRID","@value":"9000004314061"},{"@type":"NRID","@value":"9000263062232"},{"@type":"NRID","@value":"9000020879763"},{"@type":"NRID","@value":"9000366506067"},{"@type":"NRID","@value":"9000326656571"},{"@type":"NRID","@value":"9000258042791"},{"@type":"NRID","@value":"9000283463666"},{"@type":"NRID","@value":"9000001736113"},{"@type":"NRID","@value":"9000317151488"},{"@type":"NRID","@value":"9000345290652"},{"@type":"NRID","@value":"9000001892999"},{"@type":"NRID","@value":"9000024214968"},{"@type":"NRID","@value":"9000009597666"},{"@type":"NRID","@value":"9000019061193"},{"@type":"NRID","@value":"9000010975467"},{"@type":"NRID","@value":"9000016396996"},{"@type":"NRID","@value":"9000283744328"},{"@type":"NRID","@value":"9000254191836"},{"@type":"NRID","@value":"9000007157148"},{"@type":"NRID","@value":"9000241570177"},{"@type":"NRID","@value":"9000018231484"},{"@type":"NRID","@value":"9000261650623"},{"@type":"NRID","@value":"9000010114946"},{"@type":"NRID","@value":"9000241446514"},{"@type":"NRID","@value":"9000018644383"},{"@type":"NRID","@value":"9000022122407"},{"@type":"NRID","@value":"9000018870173"},{"@type":"NRID","@value":"9000016398505"},{"@type":"NRID","@value":"9000022064460"},{"@type":"NRID","@value":"9000273033762"},{"@type":"NRID","@value":"9000267852879"},{"@type":"NRID","@value":"9000001820789"},{"@type":"NRID","@value":"9000311073380"},{"@type":"NRID","@value":"9000356501745"},{"@type":"NRID","@value":"9000254191617"},{"@type":"NRID","@value":"9000283454074"},{"@type":"NRID","@value":"9000376556219"},{"@type":"NRID","@value":"9000253275193"},{"@type":"NRID","@value":"9000399222384"},{"@type":"NRID","@value":"9000018840031"},{"@type":"NRID","@value":"9000381493876"},{"@type":"NRID","@value":"9000022058002"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0143070"}],"foaf:name":[{"@value":"Kengo Takeuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567186748242445","@type":"Researcher","foaf:name":[{"@value":"Hong Guan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567186748242435","@type":"Researcher","foaf:name":[{"@value":"Yu-hua Huang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567186748242436","@type":"Researcher","foaf:name":[{"@value":"John KC Chan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"17461596"}],"prism:publicationName":[{"@value":"Diagnostic Pathology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2013-09-13","prism:volume":"8","prism:number":"1","prism:startingPage":"147"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/2.0"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1186/1746-1596-8-147.pdf"},{"@id":"http://link.springer.com/article/10.1186/1746-1596-8-147/fulltext.html"},{"@id":"https://link.springer.com/content/pdf/10.1186/1746-1596-8-147.pdf"}],"createdAt":"2013-09-13","modifiedAt":"2021-09-03","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Histology","dc:title":"Histology"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Oncogene%20Proteins,%20Fusion","dc:title":"Oncogene Proteins, Fusion"},{"@id":"https://cir.nii.ac.jp/all?q=Biopsy","dc:title":"Biopsy"},{"@id":"https://cir.nii.ac.jp/all?q=Case%20Report","dc:title":"Case Report"},{"@id":"https://cir.nii.ac.jp/all?q=Pathology%20and%20Forensic%20Medicine","dc:title":"Pathology and Forensic Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms,%20Muscle%20Tissue","dc:title":"Neoplasms, Muscle Tissue"},{"@id":"https://cir.nii.ac.jp/all?q=Young%20Adult","dc:title":"Young Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Fatal%20Outcome","dc:title":"Fatal Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Intestinal%20Neoplasms","dc:title":"Intestinal Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers,%20Tumor","dc:title":"Biomarkers, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Anaplastic%20Lymphoma%20Kinase","dc:title":"Anaplastic Lymphoma Kinase"},{"@id":"https://cir.nii.ac.jp/all?q=Genetic%20Predisposition%20to%20Disease","dc:title":"Genetic Predisposition to Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Shape","dc:title":"Cell Shape"},{"@id":"https://cir.nii.ac.jp/all?q=In%20Situ%20Hybridization,%20Fluorescence","dc:title":"In Situ Hybridization, Fluorescence"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Rearrangement","dc:title":"Gene Rearrangement"},{"@id":"https://cir.nii.ac.jp/all?q=Inflammation","dc:title":"Inflammation"},{"@id":"https://cir.nii.ac.jp/all?q=Reverse%20Transcriptase%20Polymerase%20Chain%20Reaction","dc:title":"Reverse Transcriptase Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Receptor%20Protein-Tyrosine%20Kinases","dc:title":"Receptor Protein-Tyrosine Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Tumor%20Burden","dc:title":"Tumor Burden"},{"@id":"https://cir.nii.ac.jp/all?q=Nuclear%20Pore%20Complex%20Proteins","dc:title":"Nuclear Pore Complex Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Phenotype","dc:title":"Phenotype"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Fusion","dc:title":"Gene Fusion"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Recurrence,%20Local","dc:title":"Neoplasm Recurrence, Local"},{"@id":"https://cir.nii.ac.jp/all?q=Tomography,%20X-Ray%20Computed","dc:title":"Tomography, X-Ray Computed"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Chaperones","dc:title":"Molecular Chaperones"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257215971328","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25250020"},{"@type":"JGN","@value":"JP25250020"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25250020/"}],"notation":[{"@language":"ja","@value":"病理組織学的アプローチによるtargetableながん遺伝子の新規同定"},{"@language":"en","@value":"Identification of targetable oncogenes using histopathological approaches"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285706497219456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"ALK-positive large B-cell lymphoma: identification of EML4-ALK and a review of the literature focusing on the ALK immunohistochemical staining pattern"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706929181568","@type":"Article","resourceType":"学術雑誌論文(journal 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