{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360567187448675328.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1371/journal.pone.0028367"}},{"identifier":{"@type":"URI","@value":"http://dx.plos.org/10.1371/journal.pone.0028367"}},{"identifier":{"@type":"PMID","@value":"22174794"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Cyclical and Patch-Like GDNF Distribution along the Basal Surface of Sertoli Cells in Mouse and Hamster Testes"}],"description":[{"notation":[{"@value":"In mammalian spermatogenesis, glial cell line-derived neurotrophic factor (GDNF) is one of the major Sertoli cell-derived factors which regulates the maintenance of undifferentiated spermatogonia including spermatogonial stem cells (SSCs) through GDNF family receptor α1 (GFRα1). It remains unclear as to when, where and how GDNF molecules are produced and exposed to the GFRα1-positive spermatogonia in vivo.Here we show the cyclical and patch-like distribution of immunoreactive GDNF-positive signals and their close co-localization with a subpopulation of GFRα1-positive spermatogonia along the basal surface of Sertoli cells in mice and hamsters. Anti-GDNF section immunostaining revealed that GDNF-positive signals are mainly cytoplasmic and observed specifically in the Sertoli cells in a species-specific as well as a seminiferous cycle- and spermatogenic activity-dependent manner. In contrast to the ubiquitous GDNF signals in mouse testes, high levels of its signals were cyclically observed in hamster testes prior to spermiation. Whole-mount anti-GDNF staining of the seminiferous tubules successfully visualized the cyclical and patch-like extracellular distribution of GDNF-positive granular deposits along the basal surface of Sertoli cells in both species. Double-staining of GDNF and GFRα1 demonstrated the close co-localization of GDNF deposits and a subpopulation of GFRα1-positive spermatogonia. In both species, GFRα1-positive cells showed a slender bipolar shape as well as a tendency for increased cell numbers in the GDNF-enriched area, as compared with those in the GDNF-low/negative area of the seminiferous tubules.Our data provide direct evidence of regionally defined patch-like GDNF-positive signal site in which GFRα1-positive spermatogonia possibly interact with GDNF in the basal compartment of the seminiferous tubules."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380567187448675082","@type":"Researcher","foaf:name":[{"@value":"Takeshi Sato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448674819","@type":"Researcher","foaf:name":[{"@value":"Yoshimi Aiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276186227584","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50431838"},{"@type":"NRID","@value":"1000050431838"},{"@type":"NRID","@value":"9000248218167"},{"@type":"NRID","@value":"9000382098172"},{"@type":"NRID","@value":"9000292182046"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000011725"}],"foaf:name":[{"@value":"Naoki Tsunekawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276176378752","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60551546"},{"@type":"NRID","@value":"1000060551546"},{"@type":"NRID","@value":"9000410476081"},{"@type":"NRID","@value":"9000258010305"},{"@type":"NRID","@value":"9000410151268"},{"@type":"NRID","@value":"9000001499207"},{"@type":"NRID","@value":"9000410476542"},{"@type":"NRID","@value":"9000403545426"},{"@type":"NRID","@value":"9000413480396"},{"@type":"NRID","@value":"9000345399803"},{"@type":"NRID","@value":"9000006861835"},{"@type":"NRID","@value":"9000283894112"},{"@type":"NRID","@value":"9000392065593"},{"@type":"NRID","@value":"9000398558587"},{"@type":"NRID","@value":"9000413359160"},{"@type":"NRID","@value":"9000392061143"},{"@type":"NRID","@value":"9000402262285"},{"@type":"NRID","@value":"9000392061175"},{"@type":"NRID","@value":"9000392058912"},{"@type":"NRID","@value":"9000392067267"},{"@type":"NRID","@value":"9000347224630"},{"@type":"NRID","@value":"9000347162128"},{"@type":"NRID","@value":"9000368937095"},{"@type":"NRID","@value":"9000347224819"},{"@type":"NRID","@value":"9000392069061"},{"@type":"NRID","@value":"9000411513936"},{"@type":"NRID","@value":"9000347362018"},{"@type":"NRID","@value":"9000021078193"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/haraken"}],"foaf:name":[{"@value":"Kenshiro Hara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675328","@type":"Researcher","foaf:name":[{"@value":"Akihiko Kudo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448674944","@type":"Researcher","foaf:name":[{"@value":"Hayato Kawakami"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675200","@type":"Researcher","foaf:name":[{"@value":"Michio Fujiwara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675076","@type":"Researcher","foaf:name":[{"@value":"Masami Kanai-Azuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675458","@type":"Researcher","foaf:name":[{"@value":"Mayuko Ishii-Inagaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448674822","@type":"Researcher","foaf:name":[{"@value":"Yoichi Miyamae"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801210378624","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60294138"},{"@type":"NRID","@value":"1000060294138"},{"@type":"NRID","@value":"9000415346224"},{"@type":"NRID","@value":"9000415124908"},{"@type":"NRID","@value":"9000413480406"},{"@type":"NRID","@value":"9000018395522"},{"@type":"NRID","@value":"9000283894113"},{"@type":"NRID","@value":"9000412223587"},{"@type":"NRID","@value":"9000018475199"},{"@type":"NRID","@value":"9000411520760"},{"@type":"NRID","@value":"9000001422210"},{"@type":"NRID","@value":"9000413510462"},{"@type":"NRID","@value":"9000413473990"},{"@type":"NRID","@value":"9000347362028"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0192892"}],"foaf:name":[{"@value":"Shosei Yoshida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675215","@type":"Researcher","foaf:name":[{"@value":"Makoto Seki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675459","@type":"Researcher","foaf:name":[{"@value":"Masamichi Kurohmaru"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675084","@type":"Researcher","foaf:name":[{"@value":"Seishi Maeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675335","@type":"Researcher","foaf:name":[{"@value":"Xiao Bo Zhu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675080","@type":"Researcher","foaf:name":[{"@value":"Mami Uemura-Kamata"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675078","@type":"Researcher","foaf:name":[{"@value":"Kyoko Harikae"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675072","@type":"Researcher","foaf:name":[{"@value":"Mai Shinomura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567187448675331","@type":"Researcher","foaf:name":[{"@value":"Sachi Kuwahara-Otani"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751138209792","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30260326"},{"@type":"NRID","@value":"1000030260326"},{"@type":"NRID","@value":"9000000810924"},{"@type":"NRID","@value":"9000253282317"},{"@type":"NRID","@value":"9000009971527"},{"@type":"NRID","@value":"9000415337645"},{"@type":"NRID","@value":"9000415338236"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0123258"}],"foaf:name":[{"@value":"Yoshiakira Kanai"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380567187448675214","@type":"Researcher","foaf:name":[{"@value":"Masaru Katoh"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"19326203"}],"prism:publicationName":[{"@value":"PLoS ONE"}],"dc:publisher":[{"@value":"Public Library of Science (PLoS)"}],"prism:publicationDate":"2011-12-09","prism:volume":"6","prism:number":"12","prism:startingPage":"e28367"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://dx.plos.org/10.1371/journal.pone.0028367"}],"createdAt":"2011-12-09","modifiedAt":"2024-04-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Aging","dc:title":"Aging"},{"@id":"https://cir.nii.ac.jp/all?q=Glial%20Cell%20Line-Derived%20Neurotrophic%20Factor%20Receptors","dc:title":"Glial Cell Line-Derived Neurotrophic Factor Receptors"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Photoperiod","dc:title":"Photoperiod"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Count","dc:title":"Cell Count"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Cricetinae","dc:title":"Cricetinae"},{"@id":"https://cir.nii.ac.jp/all?q=Testis","dc:title":"Testis"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Glial%20Cell%20Line-Derived%20Neurotrophic%20Factor","dc:title":"Glial Cell Line-Derived Neurotrophic Factor"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Shape","dc:title":"Cell Shape"},{"@id":"https://cir.nii.ac.jp/all?q=Sertoli%20Cells","dc:title":"Sertoli Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Stem%20Cells","dc:title":"Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=R","dc:title":"R"},{"@id":"https://cir.nii.ac.jp/all?q=Temperature","dc:title":"Temperature"},{"@id":"https://cir.nii.ac.jp/all?q=Seminiferous%20Tubules","dc:title":"Seminiferous Tubules"},{"@id":"https://cir.nii.ac.jp/all?q=Spermatogonia","dc:title":"Spermatogonia"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Transport","dc:title":"Protein Transport"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine","dc:title":"Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"},{"@id":"https://cir.nii.ac.jp/all?q=Stem%20Cell%20Transplantation","dc:title":"Stem Cell Transplantation"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782028041856","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20116004"},{"@type":"JGN","@value":"JP20116004"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20116004/"}],"notation":[{"@language":"ja","@value":"マウス精巣におけるＧＳＣ／ニッチ・システムの解明"},{"@language":"en","@value":"Investigation of GSC/niche system in the mouse testis"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782063349120","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21116501"},{"@type":"JGN","@value":"JP21116501"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21116501/"}],"notation":[{"@language":"ja","@value":"マウス支持細胞のニッチ形成能の性的可塑性"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782066441600","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21248034"},{"@type":"JGN","@value":"JP21248034"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21248034/"}],"notation":[{"@language":"ja","@value":"内胚葉形成因子SOX17の肝臓、胆管、膵臓発生における役割"},{"@language":"en","@value":"Crucial roles of SOX17 in liver-gallbladder-pancreas development"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782141651456","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23116702"},{"@type":"JGN","@value":"JP23116702"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23116702/"}],"notation":[{"@language":"ja","@value":"哺乳類の精細管内の基底区画でのＧＤＮＦの動態"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782142274816","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23132504"},{"@type":"JGN","@value":"JP23132504"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23132504/"}],"notation":[{"@language":"ja","@value":"哺乳類の卵巣の自然発症的な雄性化の分子基盤"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257024022272","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20590178"},{"@type":"JGN","@value":"JP20590178"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590178/"}],"notation":[{"@language":"ja","@value":"マウス初期内胚葉からその派生組織への分化過程におけるSox17因子の役割"},{"@language":"en","@value":"The role of Sox17 during mouse early endoderm to its delivertives"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257100075136","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22590193"},{"@type":"JGN","@value":"JP22590193"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590193/"}],"notation":[{"@language":"ja","@value":"糖鎖情報の発現様式と動的変化に関する組織細胞化学的研究"},{"@language":"en","@value":"Histochemical studies on the expression patterns and dynamical changes of carbohydrates"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257106386816","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22657058"},{"@type":"JGN","@value":"JP22657058"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22657058/"}],"notation":[{"@language":"ja","@value":"幹細胞間の競争に基づく精子品質管理機構への挑戦"},{"@language":"en","@value":"A challenge for the Quality Control of Sperm Based on Stem Cell Competition"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335802541184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Functional Differences between GDNF-Dependent and FGF2-Dependent Mouse Spermatogonial Stem Cell Self-Renewal"}]},{"@id":"https://cir.nii.ac.jp/crid/1050007846226600704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cdc42 is required for male germline niche development in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1050012711548398592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Spermatogonial stem cell transplantation into nonablated mouse recipient 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