{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360567189390422016.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3389/fimmu.2017.00669"}},{"identifier":{"@type":"URI","@value":"http://journal.frontiersin.org/article/10.3389/fimmu.2017.00669/full"}},{"identifier":{"@type":"PMID","@value":"28694804"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"CD169 Expressing Macrophage, a Key Subset in Mesenteric Lymph Nodes Promotes Mucosal Inflammation in Dextran Sulfate Sodium-Induced Colitis"}],"description":[{"notation":[{"@value":"Inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis is a relapsing-remitting illness. Patients with long-standing extensive colitis are easy to develop colorectal cancer (CRC). The increasing incidence of IBD and a substantial increase in the risk of CRC make the necessity to pay more attention on the regulation of inflammation especially by specific macrophages subset. The present study reported that a key subset of sinus macrophage expressing CD169 in mesenteric lymph nodes (mLNs) played an essential role in promoting mucosal inflammation. The results revealed that the subset expressing CD169 in mLNs increased significantly during the dextran sulfate sodium (DSS)-induced colitis. The colitic symptoms were alleviated in CD169-diphtheria toxin receptor (DTR) mice at least partially due to the deletion of CD169"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380567189390421899","@type":"Researcher","foaf:name":[{"@value":"Qiuting Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567189390422017","@type":"Researcher","foaf:name":[{"@value":"Dan Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567189390422026","@type":"Researcher","foaf:name":[{"@value":"Shengyu Hao"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567189390421901","@type":"Researcher","foaf:name":[{"@value":"Xiaolei Han"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567189390422149","@type":"Researcher","foaf:name":[{"@value":"Yuan Xia"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567189390422151","@type":"Researcher","foaf:name":[{"@value":"Xiangzhi Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567189390421889","@type":"Researcher","foaf:name":[{"@value":"Yaoxing Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276180467584","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00294059"},{"@type":"NRID","@value":"1000000294059"},{"@type":"NRID","@value":"9000240165423"},{"@type":"NRID","@value":"9000356533073"},{"@type":"NRID","@value":"9000018390174"},{"@type":"NRID","@value":"9000018282383"},{"@type":"NRID","@value":"9000404514532"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0208997"}],"foaf:name":[{"@value":"Masato Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567189390422144","@type":"Researcher","foaf:name":[{"@value":"Chun-Hong Qiu"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"16643224"}],"prism:publicationName":[{"@value":"Frontiers in Immunology"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2017-06-26","prism:volume":"8"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://journal.frontiersin.org/article/10.3389/fimmu.2017.00669/full"}],"createdAt":"2017-06-25","modifiedAt":"2017-06-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=mesenteric%20lymph%20nodes","dc:title":"mesenteric lymph nodes"},{"@id":"https://cir.nii.ac.jp/all?q=colitis","dc:title":"colitis"},{"@id":"https://cir.nii.ac.jp/all?q=CD169+%20macrophages","dc:title":"CD169+ macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=Immunology","dc:title":"Immunology"},{"@id":"https://cir.nii.ac.jp/all?q=RC581-607","dc:title":"RC581-607"},{"@id":"https://cir.nii.ac.jp/all?q=cytokines","dc:title":"cytokines"},{"@id":"https://cir.nii.ac.jp/all?q=dextran%20sulfate%20sodium","dc:title":"dextran sulfate sodium"},{"@id":"https://cir.nii.ac.jp/all?q=Immunologic%20diseases.%20Allergy","dc:title":"Immunologic diseases. 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