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Tissue Intrinsic Fluorescence Spectra-Based Digital Pathology of Liver Fibrosis by Marker-Controlled Segmentation
Bibliographic Information
- Published
- 2018-12-11
- Resource Type
- journal article
- Rights Information
-
- https://creativecommons.org/licenses/by/4.0/
- DOI
-
- 10.3389/fmed.2018.00350
- Publisher
- Frontiers Media SA
Description
Tissue intrinsic emission fluorescence provides useful diagnostic information for various diseases. Because of its unique feature of spectral profiles depending on tissue types, spectroscopic imaging is a promising tool for accurate evaluation of endogenous fluorophores. However, due to difficulties in discriminating those sources, quantitative analysis remains challenging. In this study, we quantitatively investigated spectral-spatial features of multi-photon excitation fluorescence in normal and diseased livers. For morphometrics of multi-photon excitation spectra, we examined a marker-controlled segmentation approach and its application to liver fibrosis assessment by employing a mouse model of carbon tetrachloride (CCl
Journal
-
- Frontiers in Medicine
-
Frontiers in Medicine 5 350-, 2018-12-11
Frontiers Media SA
