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Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids
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- Hidetomo Yokoo
- Division of Organic Chemistry National Institute of Health Sciences 3-25-26, Tonomachi, Kawasaki Kanagawa 210-9501 Japan
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- Motoharu Hirano
- Division of Organic Chemistry National Institute of Health Sciences 3-25-26, Tonomachi, Kawasaki Kanagawa 210-9501 Japan
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- Takashi Misawa
- Division of Organic Chemistry National Institute of Health Sciences 3-25-26, Tonomachi, Kawasaki Kanagawa 210-9501 Japan
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- Yosuke Demizu
- Division of Organic Chemistry National Institute of Health Sciences 3-25-26, Tonomachi, Kawasaki Kanagawa 210-9501 Japan
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Description
<jats:title>Abstract</jats:title><jats:p>Antimicrobial peptides (AMPs) are potential novel therapeutic drugs against microbial infections. Most AMPs function by disrupting microbial membranes because of their amphipathic properties and ordered secondary structures. In this minireview, we describe recent efforts to develop helical AMP foldamers containing non‐proteinogenic amino acids, such as α,α‐disubstituted α‐amino acids, β‐amino acids, γ‐amino acids, side‐chain stapling and N‐alkyl glycines.</jats:p>
Journal
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- ChemMedChem
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ChemMedChem 16 (8), 1226-1233, 2021-02-10
Wiley
