{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360572092829146496.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/pin.12921"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpin.12921"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/pin.12921"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pin.12921"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1111%2Fpin.12921"}},{"identifier":{"@type":"PMID","@value":"32166823"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Pathophysiology of atherothrombosis: Mechanisms of thrombus formation on disrupted atherosclerotic plaques"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Atherothrombosis is a leading cause of cardiovascular mortality and morbidity worldwide. The underlying mechanisms of atherothrombosis comprise plaque disruption and subsequent thrombus formation. Arterial thrombi are thought to mainly comprise aggregated platelets as a result of high blood velocity. However, thrombi that develop on disrupted plaques comprise not only aggregated platelets, but also large amounts of fibrin, because plaques contain large amount of tissue factor that activate the coagulation cascade. Since not all thrombi grow large enough to occlude the vascular lumen, the propagation of thrombi is also critical in the onset of adverse vascular events. Various factors such as vascular wall thrombogenicity, local hemorheology, systemic thrombogenicity and fibrinolytic activity modulate thrombus formation and propagation. Although the activation mechanisms of platelets and the coagulation cascade have been intensively investigated, the underlying mechanisms of occlusive thrombus formation on disrupted plaques remain obscure. Pathological findings derived from humans and animal models of human atherothrombosis have uncovered pathophysiological processes during thrombus formation and propagation after plaque disruption, and novel factors have been identified that modulate the activation of platelets and the coagulation cascade. These findings have also provided insights into the development of novel drugs for atherothrombosis.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380572092829146624","@type":"Researcher","foaf:name":[{"@value":"Yujiro Asada"}],"jpcoar:affiliationName":[{"@value":"Pathophysiology Section, Department of Pathology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380572092829146628","@type":"Researcher","foaf:name":[{"@value":"Atsushi Yamashita"}],"jpcoar:affiliationName":[{"@value":"Pathophysiology Section, Department of Pathology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380572092829146625","@type":"Researcher","foaf:name":[{"@value":"Yuichiro Sato"}],"jpcoar:affiliationName":[{"@value":"Department of Diagnostic Pathology, University of Miyazaki Hospital University of Miyazaki  Miyazaki Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380572092829146626","@type":"Researcher","foaf:name":[{"@value":"Kinta Hatakeyama"}],"jpcoar:affiliationName":[{"@value":"Department of Diagnostic Pathology Nara Medical University  Nara Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13205463"},{"@type":"EISSN","@value":"14401827"}],"prism:publicationName":[{"@value":"Pathology International"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2020-03-13","prism:volume":"70","prism:number":"6","prism:startingPage":"309","prism:endingPage":"322"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpin.12921"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/pin.12921"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pin.12921"},{"@id":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1111%2Fpin.12921"}],"createdAt":"2020-03-13","modifiedAt":"2023-09-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Thrombosis","dc:title":"Thrombosis"},{"@id":"https://cir.nii.ac.jp/all?q=Review%20Article","dc:title":"Review Article"},{"@id":"https://cir.nii.ac.jp/all?q=Atherosclerosis","dc:title":"Atherosclerosis"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256991403392","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19H03445"},{"@type":"JGN","@value":"JP19H03445"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03445/"}],"notation":[{"@language":"ja","@value":"アテローム血栓症の発症につながる血栓の増大・成長機序の解明"},{"@language":"en","@value":"Mechanisms of thrombus formation and propagation leading to the onset of atherothrombosis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050288789745856000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Proportion of fibrin and platelets differs in thrombi on ruptured and eroded coronary atherosclerotic plaques in humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1050570264725401472","@type":"Article","resourceType":"学術雑誌論文(journal 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