{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360574094262822016.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4049/jimmunol.0904013"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jimmunol/article-pdf/184/6/2756/62712433/ji_0904013.pdf"}}],"dc:title":[{"@value":"Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-dibehenate (TDB) are potent adjuvants for Th1/Th17 vaccination that activate Syk-Card9 signaling in APCs. In this study, we have further investigated the molecular mechanism of innate immune activation by TDM and TDB. The Syk-coupling adapter protein FcRγ was essential for macrophage activation and Th17 adjuvanticity. The FcRγ-associated C-type lectin receptor Mincle was expressed in macrophages and upregulated by TDM and TDB. Recombinant Mincle-Fc fusion protein specifically bound to the glycolipids. Genetic ablation of Mincle abolished TDM/TDB-induced macrophage activation and induction of T cell immune responses to a tuberculosis subunit vaccine. Macrophages lacking Mincle or FcRγ were impaired in the inflammatory response to Mycobacterium bovis bacillus Calmette-Guérin. These results establish that Mincle is a key receptor for the mycobacterial cord factor and controls the Th1/Th17 adjuvanticity of TDM and TDB.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380574094262821890","@type":"Researcher","foaf:name":[{"@value":"Hanne Schoenen"}],"jpcoar:affiliationName":[{"@value":"Institute of Clinical Microbiology, Immunology and Hygiene"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094262821889","@type":"Researcher","foaf:name":[{"@value":"Barbara Bodendorfer"}],"jpcoar:affiliationName":[{"@value":"Institute of Clinical Microbiology, Immunology and Hygiene"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094262822018","@type":"Researcher","foaf:name":[{"@value":"Kelly Hitchens"}],"jpcoar:affiliationName":[{"@value":"Griffith University , Queensland,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094262822020","@type":"Researcher","foaf:name":[{"@value":"Silvia Manzanero"}],"jpcoar:affiliationName":[{"@value":"Griffith University , Queensland,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094262822019","@type":"Researcher","foaf:name":[{"@value":"Kerstin Werninghaus"}],"jpcoar:affiliationName":[{"@value":"Institute of Clinical Microbiology, Immunology and Hygiene"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094262821888","@type":"Researcher","foaf:name":[{"@value":"Falk Nimmerjahn"}],"jpcoar:affiliationName":[{"@value":"Division of Rheumatology and Immunology, Medical Department, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Clinics of Erlangen , Erlangen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094262821893","@type":"Researcher","foaf:name":[{"@value":"Else Marie Agger"}],"jpcoar:affiliationName":[{"@value":"Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institut , Copenhagen,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094262821891","@type":"Researcher","foaf:name":[{"@value":"Steffen Stenger"}],"jpcoar:affiliationName":[{"@value":"Institute of Medical Microbiology, University Hospital Ulm , Ulm"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094262822021","@type":"Researcher","foaf:name":[{"@value":"Peter Andersen"}],"jpcoar:affiliationName":[{"@value":"Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institut , Copenhagen,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094262821892","@type":"Researcher","foaf:name":[{"@value":"Jürgen Ruland"}],"jpcoar:affiliationName":[{"@value":"Department of Hematology, Technical University Munich , Munich,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380307279412764416","@type":"Researcher","foaf:name":[{"@value":"Gordon D Brown"}],"jpcoar:affiliationName":[{"@value":"Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen , Aberdeen,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094262822017","@type":"Researcher","foaf:name":[{"@value":"Christine Wells"}],"jpcoar:affiliationName":[{"@value":"Griffith University , Queensland,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094262822016","@type":"Researcher","foaf:name":[{"@value":"Roland Lang"}],"jpcoar:affiliationName":[{"@value":"Institute of Clinical Microbiology, Immunology and Hygiene"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"15506606"},{"@type":"PISSN","@value":"00221767"}],"prism:publicationName":[{"@value":"The Journal of Immunology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2010-03","prism:volume":"184","prism:number":"6","prism:startingPage":"2756","prism:endingPage":"2760"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/jimmunol/article-pdf/184/6/2756/62712433/ji_0904013.pdf"}],"createdAt":"2010-02-17","modifiedAt":"2026-01-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050869456409531392","@type":"Article","resourceType":"学術雑誌論文(journal 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