{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360574094584406784.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/cas.15175"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.15175"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.15175"}},{"identifier":{"@type":"PMID","@value":"34699654"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Ferroptosis resistance determines high susceptibility of murine <i>A/J</i> strain to iron‐induced renal carcinogenesis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Cancer susceptibility is a critical factor in the understanding of carcinogenesis. Intraperitoneal (i.p.) injection of an iron chelate, ferric nitrilotriacetate (Fe‐NTA), produces hydroxyl radicals via Fenton reaction to induce ferroptosis in renal proximal tubules. Rats or mice subjected to repeated i.p. injections of Fe‐NTA develop renal cell carcinoma (RCC). To elucidate the molecular mechanisms that cause susceptibility to renal carcinogenesis, we first established an inter‐strain difference in the susceptibility to Fe‐NTA‐induced renal carcinogenesis in mice. Based on a previous observation of a low incidence of RCC with this model in <jats:italic>C57BL/6J</jats:italic> strain mice, we investigated <jats:italic>A/J</jats:italic> strain mice here, which demonstrated significantly higher susceptibility to Fe‐NTA‐induced renal carcinogenesis. Homozygous deletion of the <jats:italic>Cdkn2a/2b</jats:italic> tumor suppressor locus was detected for the first time in <jats:italic>A/J</jats:italic> strain mice. Focusing on ferroptosis and iron metabolism, we explored the mechanisms involved that lead to the difference in RCC development. We compared the protective responses in the kidney of <jats:italic>A/J</jats:italic> and <jats:italic>C57BL/6J</jats:italic> strains after Fe‐NTA treatment. After 3‐week Fe‐NTA treatment, <jats:italic>A/J</jats:italic> mice maintained higher levels of expression of glutathione peroxidase 4 and <jats:italic>x</jats:italic>CT (SLC7A11), leading to a lower level of lipid peroxidation. Simultaneously, <jats:italic>A/J</jats:italic> mice had decreased expression of transferrin receptor and increased expression of ferritin to greater degrees than <jats:italic>C57BL/6</jats:italic> mice. After a single Fe‐NTA injection, higher levels of oxidative cell damage and cytosolic catalytic Fe(II) were observed in <jats:italic>C57BL/6J</jats:italic> mice, accompanied by a greater increase in lipocalin‐2. Lipocalin‐2 deficiency significantly decreased oxidative renal damage. Our results suggest that a genetic trait favoring ferroptosis resistance contributes to high susceptibility to Fe‐NTA‐induced RCC in <jats:italic>A/J</jats:italic> strain.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380574094584406789","@type":"Researcher","foaf:name":[{"@value":"Zhen Cheng"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751139700608","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40437223"},{"@type":"NRID","@value":"1000040437223"},{"@type":"NRID","@value":"9000006847459"}],"foaf:name":[{"@value":"Shinya Akatsuka"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094584406788","@type":"Researcher","foaf:name":[{"@value":"Guang Hua Li"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751141651200","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60343232"},{"@type":"NRID","@value":"1000060343232"},{"@type":"NRID","@value":"9000239608990"},{"@type":"NRID","@value":"9000312259383"},{"@type":"NRID","@value":"9000021345479"},{"@type":"NRID","@value":"9000347361662"},{"@type":"NRID","@value":"9000002190148"},{"@type":"NRID","@value":"9000002897140"},{"@type":"NRID","@value":"9000411517230"},{"@type":"NRID","@value":"9000254177922"},{"@type":"NRID","@value":"9000002349673"},{"@type":"NRID","@value":"9000237858194"},{"@type":"NRID","@value":"9000256874644"},{"@type":"NRID","@value":"9000325822675"},{"@type":"NRID","@value":"9000253215835"},{"@type":"NRID","@value":"9000015668484"},{"@type":"NRID","@value":"9000014666626"},{"@type":"NRID","@value":"9000253627528"},{"@type":"NRID","@value":"9000397818989"},{"@type":"NRID","@value":"9000002408507"},{"@type":"NRID","@value":"9000238923767"},{"@type":"NRID","@value":"9000238912993"},{"@type":"NRID","@value":"9000256550051"},{"@type":"NRID","@value":"9000412351529"},{"@type":"NRID","@value":"9000002189767"},{"@type":"NRID","@value":"9000022219823"},{"@type":"NRID","@value":"9000312259413"},{"@type":"NRID","@value":"9000333086554"},{"@type":"NRID","@value":"9000383070303"},{"@type":"NRID","@value":"9000252911114"},{"@type":"NRID","@value":"9000253353526"},{"@type":"NRID","@value":"9000239601727"},{"@type":"NRID","@value":"9000312259415"},{"@type":"NRID","@value":"9000020204913"},{"@type":"NRID","@value":"9000347091994"},{"@type":"NRID","@value":"9000261025261"},{"@type":"NRID","@value":"9000018722079"},{"@type":"NRID","@value":"9000273021969"},{"@type":"NRID","@value":"9000256121411"},{"@type":"NRID","@value":"9000255885555"},{"@type":"NRID","@value":"9000022214961"},{"@type":"NRID","@value":"9000239601724"},{"@type":"NRID","@value":"9000264550663"},{"@type":"NRID","@value":"9000330332022"},{"@type":"NRID","@value":"9000254622109"},{"@type":"NRID","@value":"9000258619357"},{"@type":"NRID","@value":"9000253621181"},{"@type":"NRID","@value":"9000254178777"},{"@type":"NRID","@value":"9000410160125"},{"@type":"NRID","@value":"9000258083361"},{"@type":"NRID","@value":"9000022214943"},{"@type":"NRID","@value":"9000323291322"},{"@type":"NRID","@value":"9000390875065"},{"@type":"NRID","@value":"9000253215853"},{"@type":"NRID","@value":"9000254622156"},{"@type":"NRID","@value":"9000256511881"},{"@type":"NRID","@value":"9000356595724"},{"@type":"NRID","@value":"9000329440361"},{"@type":"NRID","@value":"9000359947023"},{"@type":"NRID","@value":"9000411517200"},{"@type":"NRID","@value":"9000315142354"},{"@type":"NRID","@value":"9000017193895"},{"@type":"NRID","@value":"9000252911316"},{"@type":"NRID","@value":"9000254622835"},{"@type":"NRID","@value":"9000238941605"},{"@type":"NRID","@value":"9000239601733"},{"@type":"NRID","@value":"9000254178216"},{"@type":"NRID","@value":"9000256361366"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0057279"}],"foaf:name":[{"@value":"Kiyoshi Mori"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Public Health Shizuoka Graduate University of Public Health Shizuoka Japan"},{"@value":"Department of Molecular and Clinical Pharmacology School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan"},{"@value":"Department of Nephrology and Kidney Research Shizuoka General Hospital Shizuoka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094584406787","@type":"Researcher","foaf:name":[{"@value":"Takashi Takahashi"}],"jpcoar:affiliationName":[{"@value":"Aichi Cancer Center Research Institute Nagoya Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574094584406785","@type":"Researcher","foaf:name":[{"@value":"Shinya Toyokuni"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"},{"@value":"Center for Low‐temperature Plasma Sciences Nagoya University Nagoya Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13479032"},{"@type":"EISSN","@value":"13497006"}],"prism:publicationName":[{"@value":"Cancer Science"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2021-11-23","prism:volume":"113","prism:number":"1","prism:startingPage":"65","prism:endingPage":"78"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.15175"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.15175"}],"createdAt":"2021-10-26","modifiedAt":"2023-08-27","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Nitrilotriacetic%20Acid","dc:title":"Nitrilotriacetic Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Ferric%20Compounds","dc:title":"Ferric Compounds"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Lipocalin-2","dc:title":"Lipocalin-2"},{"@id":"https://cir.nii.ac.jp/all?q=Species%20Specificity","dc:title":"Species Specificity"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Transferrin","dc:title":"Receptors, Transferrin"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Ferroptosis","dc:title":"Ferroptosis"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Regulatory%20Networks","dc:title":"Gene Regulatory Networks"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinoma,%20Renal%20Cell","dc:title":"Carcinoma, Renal Cell"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclin-Dependent%20Kinase%20Inhibitor%20p16","dc:title":"Cyclin-Dependent Kinase Inhibitor p16"},{"@id":"https://cir.nii.ac.jp/all?q=Cationic%20Amino%20Acid%20Transporter%201","dc:title":"Cationic Amino Acid Transporter 1"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclin-Dependent%20Kinase%20Inhibitor%20p15","dc:title":"Cyclin-Dependent Kinase Inhibitor p15"},{"@id":"https://cir.nii.ac.jp/all?q=Sequence%20Deletion","dc:title":"Sequence Deletion"},{"@id":"https://cir.nii.ac.jp/all?q=Homozygote","dc:title":"Homozygote"},{"@id":"https://cir.nii.ac.jp/all?q=Original%20Articles","dc:title":"Original Articles"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms,%20Experimental","dc:title":"Neoplasms, Experimental"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney%20Neoplasms","dc:title":"Kidney Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Up-Regulation","dc:title":"Up-Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Neoplastic","dc:title":"Gene Expression Regulation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20Stress","dc:title":"Oxidative Stress"},{"@id":"https://cir.nii.ac.jp/all?q=Ferritins","dc:title":"Ferritins"},{"@id":"https://cir.nii.ac.jp/all?q=Lipid%20Peroxidation","dc:title":"Lipid Peroxidation"},{"@id":"https://cir.nii.ac.jp/all?q=Injections,%20Intraperitoneal","dc:title":"Injections, Intraperitoneal"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256996120832","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K08682"},{"@type":"JGN","@value":"JP19K08682"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08682/"}],"notation":[{"@language":"ja","@value":"バイオマーカーによる腎障害介入の効果判定とその発現調節に関する研究"},{"@language":"en","@value":"Study on biomarker of kidney injury therapy and its regulation mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1040566775673710080","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20H05502"},{"@type":"JGN","@value":"JP20H05502"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-20H05502/"}],"notation":[{"@language":"ja","@value":"フェロトーシスにおける細胞内鉄制御機構の破綻"},{"@language":"en","@value":"Breakdown of iron regulatory mechanisms in ferroptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1040566775677662976","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K07588"},{"@type":"JGN","@value":"JP20K07588"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07588/"}],"notation":[{"@language":"ja","@value":"発がんにおけるDNA損傷・修復ダイナミクスの実像解明"},{"@language":"en","@value":"Elucidation of the real picture of DNA damage/repair dynamics in carcinogenesis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282813782579200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis"},{"@value":"Iron and thiol redox signaling in cancer: An exquisite balance ot escape ferroptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564288759351424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model"},{"@value":"Fenton reaction‐induced renal carcinogenesis in <i>Mutyh</i>‐deficient mice exhibits less chromosomal aberrations than the rat model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005516662606976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145224280448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146297017344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013172610585472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neutrophil gelatinase–associated lipocalin is instrumental in the pathogenesis of antibody‐mediated nephritis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013335402740480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693331688064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619415437056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure of the Human Transferrin Receptor-Transferrin Complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294645658463104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Hallmarks of Ferroptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294645687290368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Iron Oxide Nanoparticles Induce Oxidative Stress, DNA Damage, and Caspase Activation in the Human Breast Cancer Cell Line"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294646597417600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of iron on renal tubular epithelial cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298339731511808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Role of Ferric Nitrilotriacetate in Renal Carcinogenesis and Cell Death: From Animal Models to Clinical Implications"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169367942016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fenton Reaction Induced Cancer in Wild Type Rats Recapitulates Genomic Alterations Observed in Human Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170612660992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Iron and thiols as two major players in carcinogenesis: friends or foes?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189166028800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Histological detection of catalytic ferrous iron with the selective turn-on fluorescent probe RhoNox-1 in a Fenton reaction-based rat renal carcinogenesis model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094751175168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of cellular iron metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096464721024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Renal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576120422602880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ferroptosis: mechanisms and links with diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576121171937152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipocalin-2 Induces Cardiomyocyte Apoptosis by Increasing Intracellular Iron Accumulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576122702917120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Renal hemosiderosis presenting with acute kidney Injury and macroscopic hematuria in Immunoglobulin A nephropathy: a case report"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659152855808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Superiority of rat over murine model for studies on the evolution of cancer genome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567517855872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ferroptosis at the crossroads of infection, aging and cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570445065856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeting Ferroptosis to Iron Out Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570776866944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Megalin and cubilin: multifunctional endocytic receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857596133356416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The multifaceted role of iron in renal health and disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857596938217344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeting p73 in cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857597120440704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic Predisposition to Renal Cell Carcinoma: Implications for Counseling, Testing, Screening, and Management"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857597575123072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The transferrin receptor: the cellular iron gate"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707124421376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<scp>BRCA1</scp> haploinsufficiency impairs iron metabolism to promote chrysotile‐induced mesothelioma via ferroptosis resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043465663872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043560578432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipid peroxidation in cell death"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044742627840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Iron metabolism in the pathogenesis of iron-induced kidney injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045785957376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The labile iron pool: characterization, measurement, and participation in cellular processes1 1This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal."}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045962262016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Iron-induced carcinogenesis: The role of redox regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519208406528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Iron and redox cycling. Do's and don'ts"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519452886272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"4-Hydroxy-2-nonenal: a critical target in oxidative stress?"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520055719680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520431350912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996255806336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The IRP/IRE system in vivo: insights from mouse models"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469892034944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945266529280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of Ferroptotic Cancer Cell Death by GPX4"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419203904896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transferrin Receptor Is a Specific Ferroptosis Marker"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893779001472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transferrin and transferrin receptors update"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893995046656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glutathione Cycle Dependency of Ferric Nitrilotriacetate-Induced Lipid Peroxidation in Mouse Proximal Renal Tubules"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894116688640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Iron‐induced tissue damage and cancer: The role of reactive oxygen species‐free radicals"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894224613632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin–cubilin complex and transferrin receptor 1"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368437475840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370472462592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ferroptosis: Death by Lipid Peroxidation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371180614016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Iron Homeostasis Pathways as Therapeutic Targets in Acute Kidney Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843432547712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844414271360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DMT1 and iron transport"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844508370048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Haber–Weiss reaction and mechanisms of toxicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794433597440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Specific Allelic Loss of p16 Tumor Suppressor Gene after Weeks of Iron-Mediated Oxidative Damage during Rat Renal Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794750427648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of ferroptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269013962496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mammalian iron metabolism and its control by iron regulatory proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679650057600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mysterious link between iron overload and CDKN2A/2B"}]},{"@id":"https://cir.nii.ac.jp/crid/1390574058674537472","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Diluted aqueous extract of heat-not-burn tobacco product smoke causes less oxidative damage in fibroblasts than conventional cigarette"}]},{"@id":"https://cir.nii.ac.jp/crid/1390574743625422720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Iron as spirit of life to share under monopoly"}]},{"@id":"https://cir.nii.ac.jp/crid/1390868361811803520","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"<i>Mallotus japonicus</i> extract suppresses ferroptosis by inhibiting transferrin receptor-mediated ferrous ion uptake in human tubular epithelial HK2 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025648933632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449141577216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nephrotoxicity and renal cell carcinoma after use of iron- and aluminum-nitrilotriacetate complexes in rats"},{"@value":"Nephrotoxicity and renal cell carcinoma after use of iron‐ and aluminum‐nitrilotriacetate complexes in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892112951168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Environmental impact on carcinogenesis under BRCA1 haploinsufficiency"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/cas.15175"},{"@type":"KAKEN","@value":"PRODUCT-23809099"},{"@type":"KAKEN","@value":"PRODUCT-23690561"},{"@type":"KAKEN","@value":"PRODUCT-23997043"},{"@type":"OPENAIRE","@value":"doi_dedup___::97dfa42e4379ae6fb7a566239097c5fd"},{"@type":"CROSSREF","@value":"10.3164/jcbn.21-134_references_DOI_WDEddEmtCblsyMcFuqJCESwGLSO"},{"@type":"CROSSREF","@value":"10.3390/cancers14061495_references_DOI_WDEddEmtCblsyMcFuqJCESwGLSO"},{"@type":"CROSSREF","@value":"10.1186/s41021-023-00258-5_references_DOI_WDEddEmtCblsyMcFuqJCESwGLSO"},{"@type":"CROSSREF","@value":"10.3164/jcbn.22-43_references_DOI_WDEddEmtCblsyMcFuqJCESwGLSO"},{"@type":"CROSSREF","@value":"10.1016/j.redox.2022.102356_references_DOI_WDEddEmtCblsyMcFuqJCESwGLSO"},{"@type":"CROSSREF","@value":"10.1111/cas.15705_references_DOI_WDEddEmtCblsyMcFuqJCESwGLSO"},{"@type":"CROSSREF","@value":"10.3164/jcbn.25-42_references_DOI_WDEddEmtCblsyMcFuqJCESwGLSO"}]}