{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360574094589374080.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1158/1078-0432.ccr-07-1614"}},{"identifier":{"@type":"URI","@value":"https://aacrjournals.org/clincancerres/article-pdf/14/1/32/1974769/32.pdf"}},{"identifier":{"@type":"PMID","@value":"18172249"}}],"dc:title":[{"@value":"Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Purpose: Endometriotic cysts are known to transform into ovarian cancers, such as clear cell and endometrioid carcinomas. We hypothesized that an iron-rich environment produced by the repetition of hemorrhage in the endometriotic cysts during the reproductive period may play a crucial role in carcinogenesis in the cysts through the iron-induced persistent oxidative stress.</jats:p>\n               <jats:p>Experimental Design: Contents of human ovarian cysts, including 21 endometriotic cysts, 4 clear cell carcinomas, and 11 nonendometriotic cysts, were analyzed for the concentrations of free “catalytic” iron, lactose dehydrogenase, potential antioxidant, lipid peroxide, and 8-hydroxy-2′-deoxyguanosine (8-OHdG). Iron deposition and 8-OHdG levels were also analyzed histologically. Reactive oxygen species and the mutagenicity of the contents in endometriotic cyst were determined in vitro.</jats:p>\n               <jats:p>Results: The concentration of free iron in endometriotic cysts (100.9 mmol/L) was significantly higher than that in nonendometriotic cysts (0.075 mmol/L; P &lt; 0.01). The average concentrations of lactose dehydrogenase, potential antioxidant, lipid peroxide, and 8-OHdG were also significantly higher in endometriotic cysts (P &lt; 0.01). There was a correlation between the concentration of free iron and that of 8-OHdG (P &lt; 0.01). Histologically, we could observe iron deposits more abundantly in endometriotic cysts than in nonendometriotic cysts (P &lt; 0.01). The level of 8-OHdG in carcinoma associated with endometriosis was higher than that of carcinoma without endometriosis (P &lt; 0.05). In vitro analyses showed that the contents of endometriotic cyst could produce more reactive oxygen species and could induce gene mutations more frequently than the contents in the other cysts.</jats:p>\n               <jats:p>Conclusions: Abundant free iron in the contents of endometriotic cysts was strongly associated with greater oxidative stress and frequent DNA mutations. A long-standing history of the RBCs accumulated in the ovarian endometriotic cysts during the reproductive period produces oxidative stress that is a possible cause for the malignant change of the endometriotic cyst.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380576197945635972","@type":"Researcher","foaf:name":[{"@value":"Ken Yamaguchi"}],"jpcoar:affiliationName":[{"@value":"1Gynecology and Obstetrics and Departments of"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197945635968","@type":"Researcher","foaf:name":[{"@value":"Masaki Mandai"}],"jpcoar:affiliationName":[{"@value":"1Gynecology and Obstetrics and Departments of"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197945635969","@type":"Researcher","foaf:name":[{"@value":"Shinya Toyokuni"}],"jpcoar:affiliationName":[{"@value":"2Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197945635971","@type":"Researcher","foaf:name":[{"@value":"Junzo Hamanishi"}],"jpcoar:affiliationName":[{"@value":"1Gynecology and Obstetrics and Departments of"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197945635970","@type":"Researcher","foaf:name":[{"@value":"Toshihiro Higuchi"}],"jpcoar:affiliationName":[{"@value":"1Gynecology and Obstetrics and Departments of"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197945635973","@type":"Researcher","foaf:name":[{"@value":"Kenji Takakura"}],"jpcoar:affiliationName":[{"@value":"1Gynecology and Obstetrics and Departments of"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197945635974","@type":"Researcher","foaf:name":[{"@value":"Shingo Fujii"}],"jpcoar:affiliationName":[{"@value":"1Gynecology and Obstetrics and Departments of"},{"@value":"3National Hospital Organization Kyoto Medical Center, Kyoto, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10780432"},{"@type":"EISSN","@value":"15573265"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/10780432"}],"prism:publicationName":[{"@value":"Clinical Cancer Research"}],"dc:publisher":[{"@value":"American Association for Cancer Research (AACR)"}],"prism:publicationDate":"2008-01-01","prism:volume":"14","prism:number":"1","prism:startingPage":"32","prism:endingPage":"40"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://aacrjournals.org/clincancerres/article-pdf/14/1/32/1974769/32.pdf"}],"createdAt":"2008-01-03","modifiedAt":"2022-06-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=L-Lactate%20Dehydrogenase","dc:title":"L-Lactate Dehydrogenase"},{"@id":"https://cir.nii.ac.jp/all?q=Cyst%20Fluid","dc:title":"Cyst Fluid"},{"@id":"https://cir.nii.ac.jp/all?q=Iron","dc:title":"Iron"},{"@id":"https://cir.nii.ac.jp/all?q=Endometriosis","dc:title":"Endometriosis"},{"@id":"https://cir.nii.ac.jp/all?q=Deoxyguanosine","dc:title":"Deoxyguanosine"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Endometrial%20Neoplasms","dc:title":"Endometrial Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Ovarian%20Cysts","dc:title":"Ovarian Cysts"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20Stress","dc:title":"Oxidative Stress"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Transformation,%20Neoplastic","dc:title":"Cell Transformation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=8-Hydroxy-2'-Deoxyguanosine","dc:title":"8-Hydroxy-2'-Deoxyguanosine"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Reactive%20Oxygen%20Species","dc:title":"Reactive Oxygen Species"},{"@id":"https://cir.nii.ac.jp/all?q=Precancerous%20Conditions","dc:title":"Precancerous Conditions"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Damage","dc:title":"DNA Damage"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050012777807840768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"PDK2 leads to cisplatin resistance through suppression of mitochondrial function in ovarian clear cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564285747657728","@type":"Article","resourceType":"学術雑誌論文(journal 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