Simple and convenient synthesis of a fluorinated GM4 analogue

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Abstract A series of fluorinated galactosides, dodecyl 2-deoxy-2-fluoro-β- d -galactopyranoside (2F Gal), dodecyl 4-deoxy-4-fluoro-β- d -galactopyranoside (4F Gal) and dodecyl 6-deoxy-6-fluoro-β- d -galactopyranoside (6F Gal), was chemically synthesized and introduced to B16 cells to serve as scaffolds for cellular enzyme glycosylation. Results showed that the presence of fluorine exercised significant effects on cell viability. Among the fluorinated galactosides used, 2F Gal was glycosylated to afford a GM4 analogue.

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