{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360574095248883200.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2460/javma.2001.218.1787"}},{"identifier":{"@type":"URI","@value":"https://avmajournals.avma.org/view/journals/javma/218/11/javma.2001.218.1787.xml"}},{"identifier":{"@type":"URI","@value":"https://avmajournals.avma.org/downloadpdf/journals/javma/218/11/javma.2001.218.1787.xml"}}],"dc:title":[{"@value":"Prevalence of behavioral changes associated with age-related cognitive impairment in dogs"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective</jats:bold>—To determine the prevalence of age-related\nbehavioral changes, namely impairment, in a randomly\nchosen population of dogs.</jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Design</jats:bold>—Age-stratified cohort study.</jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals</jats:bold>—97 spayed female and 83 castrated male\ndogs that were 11 to 16 years old.</jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure</jats:bold>—Data on possible impairment in 4 behavioral\ncategories (ie, orientation in the home and yard,\nsocial interaction, house training, and sleep-wake cycle)\nlinked to cognitive dysfunction were obtained from dog\nowners, using a structured telephone interview.\nHospital records of dogs had been screened to exclude\ndogs with dysfunction in organ systems that may cause\nbehavioral changes. Dogs with behavioral impairment\nwere those with ≥ 2 signs of dysfunction within a category.\nDogs with impairment in 1 category were considered\nmildly impaired and those with impairment in ≥ 2\ncategories were considered severely impaired.</jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results</jats:bold>—Age by sex interactions for dogs with\nimpairment in any category were not significant, and,\ntherefore, data on castrated males and spayed\nfemales were pooled for analyses across ages. The\nprevalence of age-related progressive impairment\nwas significant in all categories. The percentage of\n11- to 12-year-old dogs with impairment in ≥ 1 category\nwas 28% (22/80), of which 10% (8/80) had\nimpairment in ≥ 2 behavioral categories. Of 15- to 16-\nyear-old dogs, 68% (23/34) had impairment in ≥ 1 category,\nof which 35% (12/34) had impairments in ≥ 2\ncategories. There were no significant effects of body\nweight on the prevalence of signs of dysfunction in\nthe behavioral categories.</jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance</jats:bold>—Data collected\nprovide estimates of the prevalence of various\ndegrees of age-related behavioral changes associated\nwith cognitive dysfunction in dogs. Age-related behavioral\nchanges may be useful indicators for medical\nintervention for dogs with signs of cognitive impairment.\n(<jats:italic>J Am Vet Med Assoc</jats:italic> 2001;218:1787–1791)</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380574095248883201","@type":"Researcher","foaf:name":[{"@value":"Jacqueline C. Neilson"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095248883200","@type":"Researcher","foaf:name":[{"@value":"Benjamin L. Hart"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095248883202","@type":"Researcher","foaf:name":[{"@value":"Kelly D. Cliff"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095248883203","@type":"Researcher","foaf:name":[{"@value":"William W. Ruehl"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00031488"}],"prism:publicationName":[{"@value":"Journal of the American Veterinary Medical Association"}],"dc:publisher":[{"@value":"American Veterinary Medical Association (AVMA)"}],"prism:publicationDate":"2001-06-01","prism:volume":"218","prism:number":"11","prism:startingPage":"1787","prism:endingPage":"1791"},"reviewed":"false","url":[{"@id":"https://avmajournals.avma.org/view/journals/javma/218/11/javma.2001.218.1787.xml"},{"@id":"https://avmajournals.avma.org/downloadpdf/journals/javma/218/11/javma.2001.218.1787.xml"}],"createdAt":"2006-01-23","modifiedAt":"2025-03-07","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360848657270833920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A new behavioral test for detecting decline of age-related cognitive ability in dogs"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206428942848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Relation between canine cognitive dysfunction and age-related brain lesions"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206428953984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in          Place-Learning Ability in Dogs"},{"@value":"Pharmacology : N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.2460/javma.2001.218.1787"},{"@type":"CROSSREF","@value":"10.1292/jvms.15-0624_references_DOI_4hU82lH2bpZwMHjlA8mmZaHZu97"},{"@type":"CROSSREF","@value":"10.1292/jvms.13-0351_references_DOI_4hU82lH2bpZwMHjlA8mmZaHZu97"},{"@type":"CROSSREF","@value":"10.1016/j.jveb.2011.09.002_references_DOI_4hU82lH2bpZwMHjlA8mmZaHZu97"}]}