{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360574095463535872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1183/09031936.00184314"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1183/09031936.00184314"}}],"dc:title":[{"@value":"Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>We assessed whether intermittent hypoxia, which emulates one of the hallmarks of obstructive sleep apnoea (OSA), leads to altered faecal microbiome in a murine model.</jats:p><jats:p><jats:italic>In vivo</jats:italic>partial pressure of oxygen was measured in colonic faeces during intermittent hypoxia in four anesthetised mice. 10 mice were subjected to a pattern of chronic intermittent hypoxia (20 s at 5% O<jats:sub>2</jats:sub>and 40 s at room air for 6 h·day<jats:sup>−1</jats:sup>) for 6 weeks and 10 mice served as normoxic controls. Faecal samples were obtained and microbiome composition was determined by 16S rRNA pyrosequencing and bioinformatic analysis by Quantitative Insights into Microbial Ecology.</jats:p><jats:p>Intermittent hypoxia exposures translated into hypoxia/re-oxygenation patterns in the faeces proximal to the bowel epithelium (<200 μm). A significant effect of intermittent hypoxia on global microbial community structure was found. Intermittent hypoxia increased the α-diversity (Shannon index, p<0.05) and induced a change in the gut microbiota (ANOSIM analysis of β-diversity, p<0.05). Specifically, intermittent hypoxia-exposed mice showed a higher abundance of Firmicutes and a smaller abundance of Bacteroidetes and Proteobacteria phyla than controls.</jats:p><jats:p>Faecal microbiota composition and diversity are altered as a result of intermittent hypoxia realistically mimicking OSA, suggesting the possibility that physiological interplays between host and gut microbiota could be deregulated in OSA.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380574095463535872","@type":"Researcher","foaf:name":[{"@value":"Isabel Moreno-Indias"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095463535879","@type":"Researcher","foaf:name":[{"@value":"Marta Torres"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095463535878","@type":"Researcher","foaf:name":[{"@value":"Josep M. Montserrat"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095463535881","@type":"Researcher","foaf:name":[{"@value":"Lidia Sanchez-Alcoholado"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095463535882","@type":"Researcher","foaf:name":[{"@value":"Fernando Cardona"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095463535880","@type":"Researcher","foaf:name":[{"@value":"Francisco J. Tinahones"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095463535875","@type":"Researcher","foaf:name":[{"@value":"David Gozal"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095463535873","@type":"Researcher","foaf:name":[{"@value":"Valeryi A. Poroyko"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095463535874","@type":"Researcher","foaf:name":[{"@value":"Daniel Navajas"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095463535877","@type":"Researcher","foaf:name":[{"@value":"Maria I. Queipo-Ortuño"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095463535876","@type":"Researcher","foaf:name":[{"@value":"Ramon Farré"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09031936"},{"@type":"EISSN","@value":"13993003"}],"prism:publicationName":[{"@value":"European Respiratory Journal"}],"dc:publisher":[{"@value":"European Respiratory Society (ERS)"}],"prism:publicationDate":"2014-12-23","prism:volume":"45","prism:number":"4","prism:startingPage":"1055","prism:endingPage":"1065"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1183/09031936.00184314"}],"createdAt":"2014-12-24","modifiedAt":"2025-02-24","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360848662689494272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Plasma Incretin Levels and Dipeptidyl Peptidase-4 Activity in Patients with Obstructive Sleep Apnea"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975846625203712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Gut microbiota modification suppresses the development of pulmonary arterial hypertension in an SU5416/hypoxia rat model"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1183/09031936.00184314"},{"@type":"CROSSREF","@value":"10.1513/annalsats.201510-697oc_references_DOI_K753MfpGcmBhd9OXk09J7BWU0nm"},{"@type":"CROSSREF","@value":"10.1177/2045894020929147_references_DOI_K753MfpGcmBhd9OXk09J7BWU0nm"}]}