{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360574095541857792.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.0711183105"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.0711183105"}},{"identifier":{"@type":"PMID","@value":"18192401"}}],"dc:title":[{"@value":"Transgenic expression of\n                    <i>Helicobacter pylori</i>\n                    CagA induces gastrointestinal and hematopoietic neoplasms in mouse"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    Infection with\n                    <jats:italic>cagA</jats:italic>\n                    -positive\n                    <jats:italic>Helicobacter pylori</jats:italic>\n                    is associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma of B cell origin. The\n                    <jats:italic>cagA</jats:italic>\n                    -encoded CagA protein is delivered into gastric epithelial cells via the bacterial type IV secretion system and, upon tyrosine phosphorylation by Src family kinases, specifically binds to and aberrantly activates SHP-2 tyrosine phosphatase, a bona fide oncoprotein in human malignancies. CagA also elicits junctional and polarity defects in epithelial cells by interacting with and inhibiting partitioning-defective 1 (PAR1)/microtubule affinity-regulating kinase (MARK) independently of CagA tyrosine phosphorylation. Despite these CagA activities that contribute to neoplastic transformation, a causal link between CagA and\n                    <jats:italic>in vivo</jats:italic>\n                    oncogenesis remains unknown. Here, we generated transgenic mice expressing wild-type or phosphorylation-resistant CagA throughout the body or predominantly in the stomach. Wild-type CagA transgenic mice showed gastric epithelial hyperplasia and some of the mice developed gastric polyps and adenocarcinomas of the stomach and small intestine. Systemic expression of wild-type CagA further induced leukocytosis with IL-3/GM-CSF hypersensitivity and some mice developed myeloid leukemias and B cell lymphomas, the hematological malignancies also caused by gain-of-function SHP-2 mutations. Such pathological abnormalities were not observed in transgenic mice expressing phosphorylation-resistant CagA. These results provide first direct evidence for the role of CagA as a bacterium-derived oncoprotein (bacterial oncoprotein) that acts in mammals and further indicate the importance of CagA tyrosine phosphorylation, which enables CagA to deregulate SHP-2, in the development of\n                    <jats:italic>H. pylori</jats:italic>\n                    -associated neoplasms.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380576197682764812","@type":"Researcher","foaf:name":[{"@value":"Naomi Ohnishi"}],"jpcoar:affiliationName":[{"@value":"*Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764811","@type":"Researcher","foaf:name":[{"@value":"Hitomi Yuasa"}],"jpcoar:affiliationName":[{"@value":"*Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764800","@type":"Researcher","foaf:name":[{"@value":"Shinya Tanaka"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular and Cellular Pathology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764804","@type":"Researcher","foaf:name":[{"@value":"Hirofumi Sawa"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001-0020, Japan;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764802","@type":"Researcher","foaf:name":[{"@value":"Motohiro Miura"}],"jpcoar:affiliationName":[{"@value":"*Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764808","@type":"Researcher","foaf:name":[{"@value":"Atsushi Matsui"}],"jpcoar:affiliationName":[{"@value":"*Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764806","@type":"Researcher","foaf:name":[{"@value":"Hideaki Higashi"}],"jpcoar:affiliationName":[{"@value":"*Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764810","@type":"Researcher","foaf:name":[{"@value":"Manabu Musashi"}],"jpcoar:affiliationName":[{"@value":"Health Administration Center, and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764803","@type":"Researcher","foaf:name":[{"@value":"Kazuya Iwabuchi"}],"jpcoar:affiliationName":[{"@value":"Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764805","@type":"Researcher","foaf:name":[{"@value":"Misao Suzuki"}],"jpcoar:affiliationName":[{"@value":"Center for Animal Resources and Development, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-0811, Japan; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764801","@type":"Researcher","foaf:name":[{"@value":"Gen Yamada"}],"jpcoar:affiliationName":[{"@value":"Center for Animal Resources and Development, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-0811, Japan; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764809","@type":"Researcher","foaf:name":[{"@value":"Takeshi Azuma"}],"jpcoar:affiliationName":[{"@value":"**Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576197682764807","@type":"Researcher","foaf:name":[{"@value":"Masanori Hatakeyama"}],"jpcoar:affiliationName":[{"@value":"*Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2008-01-22","prism:volume":"105","prism:number":"3","prism:startingPage":"1003","prism:endingPage":"1008"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.0711183105"}],"createdAt":"2008-01-11","modifiedAt":"2025-01-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20Bacterial","dc:title":"Antigens, Bacterial"},{"@id":"https://cir.nii.ac.jp/all?q=Helicobacter%20pylori","dc:title":"Helicobacter pylori"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Transgenic","dc:title":"Mice, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Neoplastic","dc:title":"Gene Expression Regulation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Transformation,%20Neoplastic","dc:title":"Cell Transformation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=Bacterial%20Proteins","dc:title":"Bacterial Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Hematologic%20Neoplasms","dc:title":"Hematologic Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphotyrosine","dc:title":"Phosphotyrosine"},{"@id":"https://cir.nii.ac.jp/all?q=Gastrointestinal%20Neoplasms","dc:title":"Gastrointestinal Neoplasms"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335818865152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA"},{"@value":"Exosomes as nanocarriers for systemic delivery of the <italic>Helicobacter pylori</italic> virulence factor CagA"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282813184617088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate"}]},{"@id":"https://cir.nii.ac.jp/crid/1050584642174116224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Toxoplasma GRA15 expression on dendritic cells inhibits B cell differentiation and antibody production"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216073988352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232370712704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233454449408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Helicobacter pylori generates cells with cancer stem cell properties via epithelial–mesenchymal transition-like changes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235496519936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bacterial EPIYA effectors - Where do they come from? What are they? Where are they going?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236376800384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Gastric Cancer Prevention by Demethylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236842571520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Differences in amino acid frequency in CagA and VacA sequences of Helicobacter pylori distinguish gastric cancer from gastric MALT lymphoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237539996544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Acquired Deficiency of A20 Results in Rapid Apoptosis, Systemic Inflammation, and Abnormal Hematopoietic Stem Cell Function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017280639692288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Animal Models and Helicobacter pylori Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022306717278464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Helicobacter Pylori Caga Status and Gastric Mucosa-Associated Lymphoid Tissue Lymphoma: A Systematic Review and Meta-Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691780627712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Helicobacter pylori CagA promotes Snail-mediated epithelial–mesenchymal transition by reducing GSK-3 activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691791530624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of disease: Helicobacter pylori virulence factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693509444224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CagA mediates epigenetic regulation to attenuate let-7 expression in\n                    <i>Helicobacter pylori</i>\n                    -related carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693782790912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707021464448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708505685760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708954509952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Potentiation of Helicobacter pylori CagA Protein Virulence through Homodimerization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709260018944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CAPZA1 determines the risk of gastric carcinogenesis by inhibiting<i>Helicobacter pylori</i>CagA-degraded autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710464462464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Natural variant of the <i>Helicobacter pylori</i> CagA oncoprotein that lost the ability to interact with <scp>PAR</scp>1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710465422848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"C‐terminal Src kinase‐mediated <scp>EPIYA</scp> phosphorylation of Pragmin creates a feed‐forward C‐terminal Src kinase activation loop that promotes cell motility"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285712468358784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evolution of cagA Oncogene of Helicobacter pylori through Recombination"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285713247518336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CEACAM6 is upregulated by <i>Helicobacter pylori</i> CagA and is a biomarker for early gastric cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285713601882624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>Helicobacter Pylori</i>\n            Virulence and Cancer Pathogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285714470708096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Metaplasia in the Stomach—Precursor of Gastric Cancer?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285714502236800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA Oncoprotein"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165694837376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of Activation-Induced Cytidine Deaminase in Inflammation-Associated Cancer Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165814416512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169361402496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Helicobacter pylori CagA Triggers Expression of the Bactericidal Lectin REG3γ via Gastric STAT3 Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183394408064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein–Barr virus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187487165824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Conformational Analysis of Isolated Domains of Helicobacter pylori CagA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187578059264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prevalence of Helicobacter pylori and its CagA subtypes in gastric cancer and duodenal ulcer at an Austrian tertiary referral center over 25 years"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189910113408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"PAR1b takes the stage in the morphogenetic and motogenetic activity of<i>Helicobacter pylori</i>CagA oncoprotein"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118753762944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584341819563648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Marked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640791108224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640791112832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641908465024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Deficiency of Claudin-18 Causes Paracellular H+ Leakage, Up-regulation of Interleukin-1β, and Atrophic Gastritis in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643109161984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epstein–Barr virus and gastric carcinoma: virus–host interactions leading to carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846645624340992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epidemiology of Helicobacter pylori and CagA-Positive Infections and Global Variations in Gastric Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656492174848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Helicobacter pylori, a carcinogen, induces the expression of melanoma antigen-encoding gene (Mage)-A3, a cancer/testis antigen"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657930849408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>Helicobacter pylori</i>as an oncogenic pathogen, revisited"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658461224832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861288396423296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>Helicobacter pylori</i>‐induced DNA double‐stranded break in the development of gastric cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861289654116608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mouse Gastric Epithelial Cells Resist CagA Delivery by the Helicobacter pylori Type IV Secretion System"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815494152832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of the 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