{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360574095820105856.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/oby.20466"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Foby.20466"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/oby.20466"}}],"dc:title":[{"@value":"Human intestinal microbiota composition is associated with local and systemic inflammation in obesity"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec><jats:title>Objective</jats:title><jats:p>Intestinal microbiota have been suggested to contribute to the development of obesity, but the mechanism remains elusive. The relationship between microbiota composition, intestinal permeability, and inflammation in nonobese and obese subjects was investigated.</jats:p></jats:sec><jats:sec><jats:title>Design and Methods</jats:title><jats:p>Fecal microbiota composition of 28 subjects (BMI 18.6‐60.3 kg m<jats:sup>−2</jats:sup>) was analyzed by a phylogenetic profiling microarray. Fecal calprotectin and plasma C‐reactive protein levels were determined to evaluate intestinal and systemic inflammation. Furthermore, HbA<jats:sub>1c</jats:sub>, and plasma levels of transaminases and lipids were analyzed. Gastroduodenal, small intestinal, and colonic permeability were assessed by a multisaccharide test.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Based on microbiota composition, the study population segregated into two clusters with predominantly obese (15/19) or exclusively nonobese (9/9) subjects. Whereas intestinal permeability did not differ between clusters, the obese cluster showed reduced bacterial diversity, a decreased Bacteroidetes/Firmicutes ratio, and an increased abundance of potential proinflammatory Proteobacteria. Interestingly, fecal calprotectin was only detectable in subjects within the obese microbiota cluster (<jats:italic>n</jats:italic> = 8/19, <jats:italic>P</jats:italic> = 0.02). Plasma C‐reactive protein was also increased in these subjects (<jats:italic>P</jats:italic> = 0.0005), and correlated with the Bacteroidetes/Firmicutes ratio (<jats:italic>r</jats:italic><jats:sub>s</jats:sub> = −0.41, <jats:italic>P</jats:italic> = 0.03).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Intestinal microbiota alterations in obese subjects are associated with local and systemic inflammation, suggesting that the obesity‐related microbiota composition has a proinflammatory effect.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380574095820105863","@type":"Researcher","foaf:name":[{"@value":"Froukje J. Verdam"}],"jpcoar:affiliationName":[{"@value":"Department of General Surgery, NUTRIM Maastricht University Medical Center Maastricht The Netherlands"},{"@value":"Department of General Surgery Atrium Medical Center Parkstad Heerlen The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095820105861","@type":"Researcher","foaf:name":[{"@value":"Susana Fuentes"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Microbiology Wageningen University Wageningen The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095820105858","@type":"Researcher","foaf:name":[{"@value":"Charlotte de Jonge"}],"jpcoar:affiliationName":[{"@value":"Department of General Surgery, NUTRIM Maastricht University Medical Center Maastricht The Netherlands"},{"@value":"Department of General Surgery Atrium Medical Center Parkstad Heerlen The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095820105857","@type":"Researcher","foaf:name":[{"@value":"Erwin G. Zoetendal"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Microbiology Wageningen University Wageningen The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095820105856","@type":"Researcher","foaf:name":[{"@value":"Runi Erbil"}],"jpcoar:affiliationName":[{"@value":"Department of General Surgery, NUTRIM Maastricht University Medical Center Maastricht The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095820105864","@type":"Researcher","foaf:name":[{"@value":"Jan Willem Greve"}],"jpcoar:affiliationName":[{"@value":"Department of General Surgery, NUTRIM Maastricht University Medical Center Maastricht The Netherlands"},{"@value":"Department of General Surgery Atrium Medical Center Parkstad Heerlen The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095820105859","@type":"Researcher","foaf:name":[{"@value":"Wim A. Buurman"}],"jpcoar:affiliationName":[{"@value":"Department of General Surgery, NUTRIM Maastricht University Medical Center Maastricht The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095820105860","@type":"Researcher","foaf:name":[{"@value":"Willem M. de Vos"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Microbiology Wageningen University Wageningen The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095820105862","@type":"Researcher","foaf:name":[{"@value":"Sander S. Rensen"}],"jpcoar:affiliationName":[{"@value":"Department of General Surgery, NUTRIM Maastricht University Medical Center Maastricht The Netherlands"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19307381"},{"@type":"EISSN","@value":"1930739X"}],"prism:publicationName":[{"@value":"Obesity"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2013-06-22","prism:volume":"21","prism:number":"12","prism:startingPage":"E607"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Foby.20466"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/oby.20466"}],"createdAt":"2013-03-22","modifiedAt":"2023-10-03","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360865816788408448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Azithromycin induces read-through of the nonsense Apc allele and prevents intestinal tumorigenesis in C3B6F1 Apc/+ mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204671719552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206325900928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Relationship between Habitual Dietary Intake and Gut Microbiota in Young Japanese Women"}]},{"@id":"https://cir.nii.ac.jp/crid/1390567172573627520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of voluntary exercise on plasma and urinary metabolites and gut microbiota in mice fed with high-fat-diet"}]},{"@id":"https://cir.nii.ac.jp/crid/1390854717509147392","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"[Review] Development of A Novel Soluble Dietary Fiber,          Isomaltodextrin (Fibryxa<sup>TM</sup>)"},{"@language":"ja","@value":"【総説：―受賞論文―】　新しい水溶性食物繊維イソマルトデキストリン(ファイバリクサ<sup>TM</sup>)の開発"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/oby.20466"},{"@type":"CROSSREF","@value":"10.5458/bag.9.1_35_references_DOI_I2JxOTzSU0vaH7Clpj83uYg0B59"},{"@type":"CROSSREF","@value":"10.3164/jcbn.15-152_references_DOI_I2JxOTzSU0vaH7Clpj83uYg0B59"},{"@type":"CROSSREF","@value":"10.3177/jnsv.63.396_references_DOI_I2JxOTzSU0vaH7Clpj83uYg0B59"},{"@type":"CROSSREF","@value":"10.7600/jpfsm.9.205_references_DOI_I2JxOTzSU0vaH7Clpj83uYg0B59"},{"@type":"CROSSREF","@value":"10.1016/j.biopha.2023.114968_references_DOI_I2JxOTzSU0vaH7Clpj83uYg0B59"}]}