{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360574095955950720.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1159/000321344"}},{"identifier":{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/321344"}}],"dc:title":[{"@value":"Renal Replacement Therapy for Prevention of Contrast-Induced Acute Kidney Injury: A Meta-Analysis of Randomized Controlled Trials"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p><i>Background:</i> Contrast-induced acute kidney injury (CI-AKI) is an important cause of acute renal injury. Several clinical trials using renal replacement therapy (RRT) for prevention of CI-AKI yielded conflicting results. We performed a meta-analysis to assess the efficacy of prophylactic RRT on CI-AKI. <i>Methods:</i> Randomized controlled trials on CI-AKI using RRT were identified without language restriction in Cochrane library, Pubmed and Embase. Data extracted from literature were analyzed with Review manager and Stata software. <i>Results:</i> Nine randomized controlled trials involving 751 patients were included. Heterogeneity was found across trials (p < 0.00001). A random effect model was used to combine the data. RRT reduced the risk of CI-AKI by 26% compared with the control group, but statistical significance was not reached (risk ratio (RR) 0.74, 95% CI 0.35–1.60, p = 0.45). Subgroup analysis of modality indicated that hemodialysis was ineffective in reducing the risk of CI-AKI (RR 1.21, 95% CI 0.63–2.32, p = 0.57), while CRRT decreased the incidence of CI-AKI (RR 0.22, 95% CI 0.07–0.64, p = 0.006). Subgroup analysis according to the CKD stage did not record heterogeneity across trials. RRT increased the odds of CI-AKI in CKD stage 3 patients (RR 1.53, 95% CI 0.07–0.64, p = 0.01), but decreased the occurrence of CI-AKI in patients with CKD stage higher than 3 (RR 0.74, 95% CI 0.35–1.60, p = 0.45). The pooled RR of the need for permanent dialysis demonstrated an insignificant trend towards benefit in patients treated with RRT (RR 0.61, 95% CI 0.26–1.40, p = 0.24). RRT reduced in-hospital mortality compared with control group (RR 0.33, 95% CI 0.14–0.77, p = 0.01). <i>Conclusion:</i> RRT fails to reduce the incidence of CI-AKI in CKD stage 3 patients, but may be beneficial in patients with more advanced renal function. CRRT is more effective than hemodialysis for prevention of CI-AKI. RRT is effective in reducing the in-hospital mortality of CI-AKI patients.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380574095955950592","@type":"Researcher","foaf:name":[{"@value":"Kai Song"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095955950720","@type":"Researcher","foaf:name":[{"@value":"Shan Jiang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095955950722","@type":"Researcher","foaf:name":[{"@value":"Yongbing Shi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095955950721","@type":"Researcher","foaf:name":[{"@value":"Huaying Shen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095955950724","@type":"Researcher","foaf:name":[{"@value":"Xiaosong Shi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095955950723","@type":"Researcher","foaf:name":[{"@value":"Donghua Jing"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02508095"},{"@type":"EISSN","@value":"14219670"}],"prism:publicationName":[{"@value":"American Journal of Nephrology"}],"dc:publisher":[{"@value":"S. Karger AG"}],"prism:publicationDate":"2010","prism:volume":"32","prism:number":"5","prism:startingPage":"497","prism:endingPage":"504"},"reviewed":"false","dc:rights":["https://www.karger.com/Services/SiteLicenses","https://www.karger.com/Services/SiteLicenses"],"url":[{"@id":"https://www.karger.com/Article/Pdf/321344"}],"createdAt":"2010-10-26","modifiedAt":"2025-04-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/2050025942143993216","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Guidelines on the use of iodinated contrast media in patients with kidney disease 2012 : digest version"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1159/000321344"},{"@type":"CROSSREF","@value":"10.1007/s11604-013-0226-4_references_DOI_GXO5VXJAc5TqDZmQlnanu4A8T2M"}]}