Mice lacking histidine decarboxylase exhibit abnormal mast cells
書誌事項
- 公開日
- 2001-07-24
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1016/s0014-5793(01)02663-1
- 公開者
- Wiley
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説明
<jats:p>Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC‐deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine‐synthesizing activity from histidine. These HDC‐deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular proteases were tremendously reduced. The HDC‐deficient mice provide a unique and promising model for studying the role of histamine in a broad range of normal and disease processes.</jats:p>
収録刊行物
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- FEBS Letters
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FEBS Letters 502 (1-2), 53-56, 2001-07-24
Wiley
