{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360574095992984960.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0014-5793(01)02663-1"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2801%2902663-1"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(01)02663-1"}},{"identifier":{"@type":"URI","@value":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2801%2902663-1"}},{"identifier":{"@type":"PMID","@value":"11478947"}}],"dc:title":[{"@value":"Mice lacking histidine decarboxylase exhibit abnormal mast cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC‐deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine‐synthesizing activity from histidine. These HDC‐deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular proteases were tremendously reduced. The HDC‐deficient mice provide a unique and promising model for studying the role of histamine in a broad range of normal and disease processes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380574095992984960","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Ohtsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984961","@type":"Researcher","foaf:name":[{"@value":"Satoshi Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992985218","@type":"Researcher","foaf:name":[{"@value":"Tadashi Terui"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992985088","@type":"Researcher","foaf:name":[{"@value":"Yoshio Hori"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984964","@type":"Researcher","foaf:name":[{"@value":"Yoko Makabe-Kobayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984965","@type":"Researcher","foaf:name":[{"@value":"Gunnar Pejler"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984967","@type":"Researcher","foaf:name":[{"@value":"Elena Tchougounova"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984968","@type":"Researcher","foaf:name":[{"@value":"Lars Hellman"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984963","@type":"Researcher","foaf:name":[{"@value":"Marina Gertsenstein"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992985219","@type":"Researcher","foaf:name":[{"@value":"Noriyasu Hirasawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984972","@type":"Researcher","foaf:name":[{"@value":"Eiko Sakurai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992985217","@type":"Researcher","foaf:name":[{"@value":"Edit Buzás"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992985221","@type":"Researcher","foaf:name":[{"@value":"Péter Kovács"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984966","@type":"Researcher","foaf:name":[{"@value":"György Csaba"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992985216","@type":"Researcher","foaf:name":[{"@value":"Ágnes Kittel"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984971","@type":"Researcher","foaf:name":[{"@value":"Mikiko Okada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992985089","@type":"Researcher","foaf:name":[{"@value":"Masahiro Hara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984969","@type":"Researcher","foaf:name":[{"@value":"Lynn Mar"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984974","@type":"Researcher","foaf:name":[{"@value":"Keiko Numayama-Tsuruta"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984970","@type":"Researcher","foaf:name":[{"@value":"Satsuki Ishigaki-Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992985220","@type":"Researcher","foaf:name":[{"@value":"Kazuo Ohuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984975","@type":"Researcher","foaf:name":[{"@value":"Atsushi Ichikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984973","@type":"Researcher","foaf:name":[{"@value":"András Falus"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992985222","@type":"Researcher","foaf:name":[{"@value":"Takehiko Watanabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574095992984962","@type":"Researcher","foaf:name":[{"@value":"András Nagy"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00145793"},{"@type":"EISSN","@value":"18733468"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/18733468"}],"prism:publicationName":[{"@value":"FEBS Letters"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2001-07-24","prism:volume":"502","prism:number":"1-2","prism:startingPage":"53","prism:endingPage":"56"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2801%2902663-1"},{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(01)02663-1"},{"@id":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2801%2902663-1"}],"createdAt":"2002-07-25","modifiedAt":"2023-09-17","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Rodent","dc:title":"Rodent"},{"@id":"https://cir.nii.ac.jp/all?q=Knockout","dc:title":"Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Histidine%20Decarboxylase","dc:title":"Histidine Decarboxylase"},{"@id":"https://cir.nii.ac.jp/all?q=Mast%20cell","dc:title":"Mast cell"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Mast%20Cells","dc:title":"Mast Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Alleles","dc:title":"Alleles"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine","dc:title":"Histamine"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050285700369165696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming"}]},{"@id":"https://cir.nii.ac.jp/crid/1050568937739702144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interleukin-1 and histamine are essential for inducing 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eosinophilia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692365477248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283695889437952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prostaglandin E2–EP3 Signaling Induces Inflammatory Swelling by Mast Cell Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285705073580416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histamine synthesis is required for granule maturation in murine mast cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706978141312","@type":"Article","resourceType":"学術雑誌論文(journal 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effects of the non-nitrogen-containing bisphosphonates etidronate and clodronate, independent of anti-resorptive effects on bone"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565167088051968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histamine modulation of the basal ganglia circuitry in the development of pathological grooming"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169417198080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180110210048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of prostaglandins and histamine in nickel wire‐induced acute inflammation in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182172716672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The elicitation step of nickel allergy is promoted in mice by microbe-related substances, including some from oral bacteria"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183496380416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184565166208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185467063808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histamine suppresses regulatory <scp>T</scp> cells mediated by <scp>TGF</scp>‐<i>β</i> in murine chronic allergic contact dermatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187514353792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Role of Histamine in the Retina: Studies on the Hdc Knockout Mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232407497216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histamine acts via H4-receptor stimulation to cause augmented inflammation when lipopolysaccharide is co-administered with a nitrogen-containing bisphosphonate"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580624877138944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mast cells link immune sensing to antigen-avoidance behaviour"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641024212992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642074809728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643941396992","@type":"Article","resourceType":"学術雑誌論文(journal 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patients are also produced by histamine deficiency in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363664919004899200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204147919360","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular biology of histidine decarboxylase and prostaglandin receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204272611200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Towards Understanding Mechanisms of Drug Action and Functions of the Body on the Molecular Level. Studies on histamine with L-histidine decarboxylase, a histamine-forming enzyme, as a probe: from purification to gene knockout."},{"@language":"ja","@value":"薬の作用機序と生体機能の分子的理解に向けて　　ヒスタミンに関する研究　　ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@value":"ヒスタミンに関する研究:ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@language":"ja-Kana","@value":"ヒスタミン ニ カンスル ケンキュウ ヒスチジン ダツタンサン コウソ ノ セイセイ カラ ケッソン マウス マデ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204273685504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Regulatory mechanism of gastric acid secretion and mucosal integrity. An analysis with various gene deficient mice."},{"@language":"ja","@value":"薬理学におけるトランスレーショナルリサーチ　　基盤研究から臨床まで　　各種遺伝子改変マウスを用いた胃酸分泌および胃粘膜細胞の恒常性の解明"},{"@value":"各種遺伝子改変マウスを用いた胃酸分泌および胃粘膜細胞の恒常性の解明"},{"@language":"ja-Kana","@value":"カクシュ イデンシ カイヘン マウス オ モチイタ イサン ブンピ オヨビ イ ネンマク サイボウ ノ コウジョウセイ ノ カイメイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204632456832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Roles of Histamine in Exercise-Induced Fatigue: Favouring Endurance and Protecting against Exhaustion"},{"@value":"Highlighted Paper selected by Editor-in-Chief : Roles of Histamine in Exercise-Induced Fatigue : Favouring Endurance and Protecting against Exhaustion"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204632596352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Corrigendum: Enhanced Goblet Cell Hyperplasia in HDC Knockout Mice with Allergic Airway Inflammation [Allergol Int 2009;58:125-134]"},{"@value":"Enhanced Goblet Cell Hyperplasia in HDC Knockout Mice with Allergic Airway Inflammation"},{"@value":"Corrigendum to Enhanced Goblet Cell Hyperplasia in HDC Knockout Mice with Allergic Airway Inflammation by Kohei Yamauchi, Hong Mei Piao, Toshihide Nakadate, Toshiki Shikanai, Yutaka Nakamura, Harumasa Ito, Takashi Mouri, Hitoshi Kobayashi, Chihaya Maesawa, Takashi Sawai, Hiroshi Ohtsu and Hiroshi Inoue. 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