{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360574096035566976.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.1316278111"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.1316278111"}}],"dc:title":[{"@value":"DNA-binding specificities of plant transcription factors and their potential to define target genes"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Significance</jats:title>\n          <jats:p>\n            We described the high-throughput identification of DNA-binding specificities of 63 plant transcription factors (TFs) and their relevance as\n            <jats:italic>cis-</jats:italic>\n            regulatory elements in vivo. Almost half of the TFs recognized secondary motifs partially or completely differing from their corresponding primary ones. Analysis of coregulated genes, transcriptomic data, and chromatin hypersensitive regions revealed the biological relevance of more than 80% of the binding sites identified. Our combined analysis allows the prediction of the function of a particular TF as activator or repressor through a particular DNA sequence. The data support the correlation between\n            <jats:italic>cis-</jats:italic>\n            regulatory elements in vivo and the sequence determined in vitro. Moreover, it provides a framework to explore regulatory networks in plants and contributes to decipher the transcriptional regulatory code.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380574096035566977","@type":"Researcher","foaf:name":[{"@value":"José M. Franco-Zorrilla"}],"jpcoar:affiliationName":[{"@value":"Genomics Unit and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574096035566980","@type":"Researcher","foaf:name":[{"@value":"Irene López-Vidriero"}],"jpcoar:affiliationName":[{"@value":"Genomics Unit and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574096035567104","@type":"Researcher","foaf:name":[{"@value":"José L. Carrasco"}],"jpcoar:affiliationName":[{"@value":"Instituto de Biología Molecular y Celular de Plantas, Universidad Politécnica de Valencia-Consejo Superior de Investigaciones Científicas, 46022 Valencia, Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574096035566979","@type":"Researcher","foaf:name":[{"@value":"Marta Godoy"}],"jpcoar:affiliationName":[{"@value":"Genomics Unit and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574096035566978","@type":"Researcher","foaf:name":[{"@value":"Pablo Vera"}],"jpcoar:affiliationName":[{"@value":"Instituto de Biología Molecular y Celular de Plantas, Universidad Politécnica de Valencia-Consejo Superior de Investigaciones Científicas, 46022 Valencia, Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574096035566976","@type":"Researcher","foaf:name":[{"@value":"Roberto Solano"}],"jpcoar:affiliationName":[{"@value":"Department of Plant Molecular Genetics, Centro Nacional de Biotecnología (CNB)-Consejo Superior de Investigaciones Científicas (CSIC), Darwin 3, 28049 Madrid, Spain; and"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2014-01-29","prism:volume":"111","prism:number":"6","prism:startingPage":"2367","prism:endingPage":"2372"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.1316278111"}],"createdAt":"2014-01-30","modifiedAt":"2022-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282813267502592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transcription factor DUO1 generated by neo-functionalization is associated with evolution of sperm differentiation in 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