{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360574096560527872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0006-8993(00)03226-1"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006899300032261?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006899300032261?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"11164807"}},{"identifier":{"@type":"NAID","@value":"30003069803"}}],"dc:title":[{"@value":"Food-deprived activity stress decreased the activity of the histaminergic neuron system in rats"}],"description":[{"notation":[{"@value":"The hypothalamus, which is rich in histaminergic neurons, is highly sensitive to aversive stimuli such as stress. Histamine H3 receptors, which regulate histamine release from the presynaptic site, are associated with stress-induced brain activity. In this study, we investigated the changes of histamine content and histamine H1 and H3 receptors in the brains of rats subjected to stress induced through food deprivation and physical activity on a running wheel (food-deprived activity stress). For purposes of comparison, we also examined the stressful effects of forced swimming on the histaminergic neuron system of rats. The H3 receptor density rapidly declined in the acute phase of stress but gradually returned to the control level in the chronic phase. On the other hand, the H1 receptor slowly decreased and remained at a low level during the chronic phase. These results reveal that there is a discrepancy between the levels of H1 and H3 receptors in the acute and chronic phases of stress. Brain histamine content gradually increased during the late phase of both food-deprived activity stress and forced swimming stress. These changes presumably resulted in the inhibition of histaminergic neuronal activity in the chronic stress condition. In accordance with this hypothesis, the intraventricular administration of histamine significantly reduced the hyperactivity caused by food-deprived activity stress. Since extensive exercise and restricted feeding are thought to be associated with anorexia nervosa, the abnormalities in the histaminergic neuron system might contribute to trait status in anorexia nervosa."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380574096560527874","@type":"Researcher","foaf:name":[{"@value":"Masatoshi Endou"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574096560527872","@type":"Researcher","foaf:name":[{"@value":"Kazuhiko Yanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574096560527876","@type":"Researcher","foaf:name":[{"@value":"Eiko Sakurai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574096560527875","@type":"Researcher","foaf:name":[{"@value":"Shin Fukudo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574096560527877","@type":"Researcher","foaf:name":[{"@value":"Michio Hongo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380574096560527873","@type":"Researcher","foaf:name":[{"@value":"Takehiko Watanabe"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00068993"},{"@type":"NCID","@value":"AA0057324X"}],"prism:publicationName":[{"@value":"Brain Research"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2001-02","prism:volume":"891","prism:number":"1-2","prism:startingPage":"32","prism:endingPage":"41"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006899300032261?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006899300032261?httpAccept=text/plain"}],"createdAt":"2002-07-25","modifiedAt":"2025-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Neurons","dc:title":"Neurons"},{"@id":"https://cir.nii.ac.jp/all?q=Binding%20Sites","dc:title":"Binding Sites"},{"@id":"https://cir.nii.ac.jp/all?q=Body%20Weight","dc:title":"Body Weight"},{"@id":"https://cir.nii.ac.jp/all?q=Brain","dc:title":"Brain"},{"@id":"https://cir.nii.ac.jp/all?q=Motor%20Activity","dc:title":"Motor Activity"},{"@id":"https://cir.nii.ac.jp/all?q=Circadian%20Rhythm","dc:title":"Circadian Rhythm"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Sprague-Dawley","dc:title":"Rats, Sprague-Dawley"},{"@id":"https://cir.nii.ac.jp/all?q=Radioligand%20Assay","dc:title":"Radioligand Assay"},{"@id":"https://cir.nii.ac.jp/all?q=Stress,%20Physiological","dc:title":"Stress, Physiological"},{"@id":"https://cir.nii.ac.jp/all?q=Neural%20Pathways","dc:title":"Neural Pathways"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Histamine","dc:title":"Receptors, Histamine"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Histamine%20H3","dc:title":"Receptors, Histamine H3"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Histamine%20H1","dc:title":"Receptors, Histamine H1"},{"@id":"https://cir.nii.ac.jp/all?q=Food%20Deprivation","dc:title":"Food Deprivation"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine","dc:title":"Histamine"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360857593735176064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histamine Neuroimaging in Stress-Related Disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204238968576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Studies on Functional Roles of the Histaminergic Neuron System by Using Pharmacological Agents, Knockout Mice and Positron Emission Tomography."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204272611200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Towards Understanding Mechanisms of Drug Action and Functions of the Body on the Molecular Level. Studies on histamine with L-histidine decarboxylase, a histamine-forming enzyme, as a probe: from purification to gene knockout."},{"@language":"ja","@value":"薬の作用機序と生体機能の分子的理解に向けて　　ヒスタミンに関する研究　　ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@value":"ヒスタミンに関する研究:ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@language":"ja-Kana","@value":"ヒスタミン ニ カンスル ケンキュウ ヒスチジン ダツタンサン コウソ ノ セイセイ カラ ケッソン マウス マデ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204625369856","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Histamine H1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205178475136","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Histamine on Lipid Metabolic Disorder in Mice Loaded With Restraint Stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206479196160","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of a Chicken Extract on Food-Deprived Activity Stress in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649841656192","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ラットヒスタミン神経系の食事制限下ストレス負荷に対するストレス反応抑制効果"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449874453120","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ストレスにおける脳内ヒスタミンの役割とチキンエキスの抗ストレス作用"},{"@language":"en","@value":"Anti-stress effects of chicken extracts may be mediated through the functions of neuronal histamine"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874585474304","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"チキンエキスは脳内ヒスタミン神経系を介してストレスに抵抗する"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/s0006-8993(00)03226-1"},{"@type":"CIA","@value":"30003069803"},{"@type":"OPENAIRE","@value":"doi_dedup___::a6d9e28b61cc7a906416a714dee66025"},{"@type":"CROSSREF","@value":"10.1254/jphs.09090fp_references_DOI_ZaLSl57bv5vyQ6ZNDjBrEzQAIAm"},{"@type":"CROSSREF","@value":"10.1271/bbb.90950_references_DOI_ZaLSl57bv5vyQ6ZNDjBrEzQAIAm"},{"@type":"CROSSREF","@value":"10.1248/bpb.32.51_references_DOI_ZaLSl57bv5vyQ6ZNDjBrEzQAIAm"},{"@type":"CROSSREF","@value":"10.1254/fpj.118.159_references_DOI_ZaLSl57bv5vyQ6ZNDjBrEzQAIAm"},{"@type":"CROSSREF","@value":"10.1007/7854_2021_262_references_DOI_ZaLSl57bv5vyQ6ZNDjBrEzQAIAm"}]}