Selective increment of phosphatidylserine on the autophagic body membrane in the yeast vacuole
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- Yuki Yamakuchi
- Department of Molecular and Cell Biology and Biochemistry Basic Veterinary Science Faculty of Veterinary Medicine Kagoshima University Kagoshima Japan
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- Yuna Kurokawa
- Department of Molecular and Cell Biology and Biochemistry Basic Veterinary Science Faculty of Veterinary Medicine Kagoshima University Kagoshima Japan
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- Rikako Konishi
- Department of Molecular and Cell Biology and Biochemistry Basic Veterinary Science Faculty of Veterinary Medicine Kagoshima University Kagoshima Japan
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- Kayoko Fukuda
- Department of Molecular and Cell Biology and Biochemistry Basic Veterinary Science Faculty of Veterinary Medicine Kagoshima University Kagoshima Japan
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- Tatsunori Masatani
- Transboundary Animal Diseases Research Center Joint Faculty of Veterinary Medicine Kagoshima University Kagoshima Japan
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- Akikazu Fujita
- Department of Molecular and Cell Biology and Biochemistry Basic Veterinary Science Faculty of Veterinary Medicine Kagoshima University Kagoshima Japan
書誌事項
- 公開日
- 2021-08-14
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/1873-3468.14167
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>In yeast cells, the autophagosome is a double‐membrane structure; the inner membrane becomes the autophagic body membrane in the vacuole. Vacuolar enzymes degrade the autophagic body. There is no critical information regarding its selective degradation. Using the electron microscopy method, distributions of four phospholipids were examined in the autophagosomal and autophagic body membranes upon autophagy induction. The labeling of phosphatidylserine (PtdSer) in the autophagic body membrane dramatically increased after it converted from the autophagosome, but remained low in the vacuolar membrane. PtdSer in the autophagic body membrane also increased in <jats:italic>atg15</jats:italic>∆ yeast. These results suggest that the selective increment of PtdSer in the autophagic body, but not the vacuolar, membrane, can explain the selective degradation of the autophagic membrane.</jats:p>
収録刊行物
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- FEBS Letters
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FEBS Letters 595 (17), 2197-2207, 2021-08-14
Wiley
