{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360580229826945920.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.neuint.2023.105517"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0197018623000451?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0197018623000451?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"36913980"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Quantitative analysis of NMDA receptor subunits proteins in mouse brain"}],"description":[{"notation":[{"@value":"NMDA-type glutamate receptors (NMDARs) are tetrameric channel complex composed of two subunits of GluN1, which is encoded by a single gene and diversified by alternative splicing, and two subunits from four subtypes of GluN2, leading to various combinations of subunits and channel specificities. However, there is no comprehensive quantitative analysis of GluN subunit proteins for relative comparison, and their compositional ratios at various regions and developmental stages have not been clarified. Here we prepared six chimeric subunits, by fusing an N-terminal side of the GluA1 subunit with a C-terminal side of each of two splicing isoforms of GluN1 subunit and four GluN2 subunits, with which titers of respective NMDAR subunit antibodies could be standardized using common GluA1 antibody, thus enabling quantification of relative protein levels of each NMDAR subunit by western blotting. We determined relative protein amounts of NMDAR subunits in crude, membrane (P2) and microsomal fractions prepared from the cerebral cortex, hippocampus and cerebellum in adult mice. We also examined amount changes in the three brain regions during developmental stages. Their relative amounts in the cortical crude fraction were almost parallel to those of mRNA expression, except for some subunits. Interestingly, a considerable amount of GluN2D protein existed in adult brains, although its transcription level declines after early postnatal stages. GluN1 was larger in quantity than GluN2 in the crude fraction, whereas GluN2 increased in the membrane component-enriched P2 fraction, except in the cerebellum. These data will provide the basic spatio-temporal information on the amount and composition of NMDARs."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380580229826945792","@type":"Researcher","foaf:name":[{"@value":"Yasuhiro Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580229826946050","@type":"Researcher","foaf:name":[{"@value":"Chihiro Nakamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580229826945804","@type":"Researcher","foaf:name":[{"@value":"Izumi Watanabe-Iida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580229826945941","@type":"Researcher","foaf:name":[{"@value":"Masahiko Watanabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580229826945940","@type":"Researcher","foaf:name":[{"@value":"Tomonori Takeuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580229826945922","@type":"Researcher","foaf:name":[{"@value":"Toshikuni Sasaoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751147200000","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10334674"},{"@type":"NRID","@value":"1000010334674"},{"@type":"NRID","@value":"9000412230009"},{"@type":"NRID","@value":"9000003185850"},{"@type":"NRID","@value":"9000404511786"},{"@type":"NRID","@value":"9000022534247"},{"@type":"NRID","@value":"9000410476576"},{"@type":"NRID","@value":"9000413498166"},{"@type":"NRID","@value":"9000024439163"},{"@type":"NRID","@value":"9000006011514"},{"@type":"NRID","@value":"9000242351350"},{"@type":"NRID","@value":"9000333924107"},{"@type":"NRID","@value":"9000004275349"},{"@type":"NRID","@value":"9000413500415"},{"@type":"NRID","@value":"9000363500668"},{"@type":"NRID","@value":"9000413476935"},{"@type":"NRID","@value":"9000402941871"},{"@type":"NRID","@value":"9000412603691"},{"@type":"NRID","@value":"9000290372280"},{"@type":"NRID","@value":"9000414803058"},{"@type":"NRID","@value":"9000368412397"},{"@type":"NRID","@value":"9000399769318"},{"@type":"NRID","@value":"9000243891018"},{"@type":"NRID","@value":"9000241573291"},{"@type":"NRID","@value":"9000413504054"},{"@type":"NRID","@value":"9000375922051"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/abemanabu"}],"foaf:name":[{"@value":"Manabu Abe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580229826945930","@type":"Researcher","foaf:name":[{"@value":"Kenji Sakimura"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01970186"}],"prism:publicationName":[{"@value":"Neurochemistry International"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2023-05","prism:volume":"165","prism:startingPage":"105517"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0197018623000451?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0197018623000451?httpAccept=text/plain"}],"createdAt":"2023-03-11","modifiedAt":"2025-10-01","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Subunits","dc:title":"Protein Subunits"},{"@id":"https://cir.nii.ac.jp/all?q=Mouse%20brain","dc:title":"Mouse brain"},{"@id":"https://cir.nii.ac.jp/all?q=Quantification","dc:title":"Quantification"},{"@id":"https://cir.nii.ac.jp/all?q=Cerebellum","dc:title":"Cerebellum"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Brain","dc:title":"Brain"},{"@id":"https://cir.nii.ac.jp/all?q=Glutamic%20Acid","dc:title":"Glutamic Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Western%20blot","dc:title":"Western blot"},{"@id":"https://cir.nii.ac.jp/all?q=Development","dc:title":"Development"},{"@id":"https://cir.nii.ac.jp/all?q=NMDA%20receptor","dc:title":"NMDA receptor"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20N-Methyl-D-Aspartate","dc:title":"Receptors, N-Methyl-D-Aspartate"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782006697088","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18KK0458"},{"@type":"JGN","@value":"JP18KK0458"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0458/"}],"notation":[{"@language":"ja","@value":"コンディショナル変異ラットを用いた記憶保持の強化の分子機構解明"},{"@language":"en","@value":"Assessing molecular mechanisms of enhancement of memory retention using rats carrying conditional alleles."}]},{"@id":"https://cir.nii.ac.jp/crid/1040573407559904768","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22H04922"},{"@type":"JGN","@value":"JP22H04922"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04922/"}],"notation":[{"@language":"ja","@value":"先端モデル動物支援プラットフォーム"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050025031479078016","@type":"Article","resourceType":"学術雑誌論文(journal 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hippocampal CA3 subfield"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369116074368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NMDA receptor structures reveal subunit arrangement and pore architecture"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843885987200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular cloning and characterization of the rat NMDA receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844181823232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844298448000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NMDA receptor subunits GluRε1, GluRε3 and GluRζ1 are enriched at the mossy fibre–granule cell synapse in the adult mouse cerebellum"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845081872640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NMDA Receptor GluRϵ/NR2 Subunits Are Essential for Postsynaptic Localization and Protein Stability of GluRζ1/NR1 Subunit"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845239481984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TARPs γ‐2 and γ‐7 are essential for AMPA receptor expression in the cerebellum"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846262336384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Developmental and regional expression in the rat brain and functional properties of four NMDA receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319278314624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1Com, NR2A, NR2B, NR2C, NR2D and NR3A"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319318802944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319456189824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321056763776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"pEF-BOS, a powerful mammalian expression vector"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321120142976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NMDA Receptors Containing the GluN2D Subunit Control Neuronal Function in the Subthalamic Nucleus"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268269837568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cloning, expression and modulation of a mouse NMDA receptor subunit"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268488134016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700772779776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Conditional gene targeting on the pure C57BL/6 genetic 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