{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360580230613745792.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.ekir.2022.10.010"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2468024922018228?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2468024922018228?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"36644361"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Overexpression of Plasmalemmal Vesicle-Associated Protein-1 Reflects Glomerular Endothelial Injury in Cases of Proliferative Glomerulonephritis with Monoclonal IgG Deposits"}],"description":[{"notation":[{"@value":"Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) occasionally presents refractory nephrotic syndrome resulting in poor renal prognosis, but its etiology is not fully elucidated. Given that glomerular endothelial cell (GEC) stress or damage may lead to podocytopathy and subsequent proteinuria, as in thrombotic microangiopathy (TMA), diabetic kidney disease, and focal segmental glomerulosclerosis, we investigated the evidence of glomerular endothelial injury by evaluating the expression of plasmalemmal vesicle-associated protein-1 (PV-1), a component of caveolae in the cases of PGNMID.We measured the immunofluorescent PV-1 intensities of 23 PGNMID cases and compared with those of primary membranoproliferative glomerulonephritis (MPGN) (The intensity of glomerular PV-1 expression in PGNMID is significantly higher than that in the other glomerular diseases, although the intensity is not associated with clinical outcomes such as urinary protein levels or renal prognosis. Immunostaining and LVSEM analysis revealed that glomerular PV-1 expression is localized in GECs in PGNMID. 8-oxoguanine accumulation was detected in WT1-positive podocytes but not in PV-1-expressing GECs, suggesting GEC-derived podocyte injury in PGNMID.PV-1 overexpression reflects glomerular endothelial injury, which could be associated with podocyte oxidative stress in PGNMID cases."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380580230613745810","@type":"Researcher","foaf:name":[{"@value":"Anri Sawada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580230613745807","@type":"Researcher","foaf:name":[{"@value":"Kunio Kawanishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580230613745805","@type":"Researcher","foaf:name":[{"@value":"Yuto Igarashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580230613745944","@type":"Researcher","foaf:name":[{"@value":"Sekiko Taneda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580230613745818","@type":"Researcher","foaf:name":[{"@value":"Motoshi 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Nagashima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580230613745673","@type":"Researcher","foaf:name":[{"@value":"Kosaku Nitta"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"24680249"}],"prism:publicationName":[{"@value":"Kidney International Reports"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2023-01","prism:volume":"8","prism:number":"1","prism:startingPage":"151","prism:endingPage":"163"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S2468024922018228?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S2468024922018228?httpAccept=text/plain"}],"createdAt":"2022-10-19","modifiedAt":"2025-11-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Clinical%20Research","dc:title":"Clinical 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