{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360580232425249024.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.isci.2022.105412"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2589004222016844?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2589004222016844?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"36320329"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity"}],"description":[{"notation":[{"@value":"Live-attenuated vaccines are generally highly effective. Here, we aimed to develop one against SARS-CoV-2, based on the identification of three types of temperature-sensitive (TS) strains with mutations in nonstructural proteins (nsp), impaired proliferation at 37°C-39°C, and the capacity to induce protective immunity in Syrian hamsters. To develop a live-attenuated vaccine, we generated a virus that combined all these TS-associated mutations (rTS-all), which showed a robust TS phenotype"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380580232425249293","@type":"Researcher","foaf:name":[{"@value":"Akiho Yoshida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249028","@type":"Researcher","foaf:name":[{"@value":"Shinya Okamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249284","@type":"Researcher","foaf:name":[{"@value":"Shiho Torii"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249288","@type":"Researcher","foaf:name":[{"@value":"Sayuri Komatsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249291","@type":"Researcher","foaf:name":[{"@value":"Paola Miyazato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249035","@type":"Researcher","foaf:name":[{"@value":"Hitomi Sasaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249154","@type":"Researcher","foaf:name":[{"@value":"Shiori Ueno"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249162","@type":"Researcher","foaf:name":[{"@value":"Hidehiko Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249030","@type":"Researcher","foaf:name":[{"@value":"Wataru Kamitani"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249027","@type":"Researcher","foaf:name":[{"@value":"Chikako Ono"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249031","@type":"Researcher","foaf:name":[{"@value":"Yoshiharu Matsuura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249289","@type":"Researcher","foaf:name":[{"@value":"Shiro Takekawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249168","@type":"Researcher","foaf:name":[{"@value":"Koichi Yamanishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580232425249294","@type":"Researcher","foaf:name":[{"@value":"Hirotaka Ebina"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"25890042"}],"prism:publicationName":[{"@value":"iScience"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2022-11","prism:volume":"25","prism:number":"11","prism:startingPage":"105412"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S2589004222016844?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S2589004222016844?httpAccept=text/plain"}],"createdAt":"2022-10-20","modifiedAt":"2025-11-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Biological%20sciences","dc:title":"Biological 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