{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360580235956587904.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/bcp.14713"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.14713"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/bcp.14713"}},{"identifier":{"@type":"URI","@value":"https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.14713"}},{"identifier":{"@type":"PMID","@value":"33368448"}}],"dc:title":[{"@value":"Adverse outcomes of proton pump inhibitors in patients with chronic kidney disease: The CKD‐REIN cohort study"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec><jats:title>Aims</jats:title><jats:p>Long‐term use of proton pump inhibitors (PPIs) has been associated with adverse kidney events in the general population, but their impact among chronic kidney disease (CKD) patients is unclear. We studied the prevalence and incidence (new users) of PPI prescriptions and their relation to kidney outcomes and mortality in CKD patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We collected drug prescriptions prospectively in a cohort of 3023 nephrology outpatients with CKD stages 2–5 at inclusion. Hazard ratios (HR, 95% confidence intervals [95% CI]) for acute kidney injury (AKI), end‐stage kidney disease (ESKD), and mortality associated with new PPI prescriptions as a time‐dependent variable were estimated with cause‐specific Cox models in 1940 non‐users with eGFR ≥ 15 mL/min/1.73 m<jats:sup>2</jats:sup> at baseline, adjusted for comorbidities, laboratory data and drugs.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>There were 981/3023 (32%) prevalent users (67 ± 13 years, 65% men) at baseline, and 366/3023 (12%) were prescribed PPI (new users) over a median follow‐up of 3.9 years (interquartile range, 3–4.2). Among these new users, their median cumulative duration of prescription was 1 year (interquartile range: 0.4–2.3). During follow‐up, 354 patients developed ESKD and 216 died before ESKD. The adjusted HRs associated with PPI prescription were 1.74 (95% CI, 1.26–2.40) for ESKD and 2.42 (95% CI, 1.73–3.39) for all‐cause mortality. Over the first 3 years of follow‐up, 211 AKI events had occurred. The adjusted HR for AKI associated with PPI prescription was 2.89 (95% CI, 1.91–4.38).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Long‐term PPI prescription was common in CKD patients. Our results call attention to its potential risks of both acute and chronic kidney failure.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380580235956587907","@type":"Researcher","foaf:name":[{"@value":"Sophie Liabeuf"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Pharmacology Amiens University Hospital  Amiens France"},{"@value":"Laboratory, EA7517 University of Picardie Jules Verne  Amiens Amiens France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580235956587914","@type":"Researcher","foaf:name":[{"@value":"Oriane Lambert"}],"jpcoar:affiliationName":[{"@value":"Centre for Research in Epidemiology and Population Health (CESP), Paris‐Saclay University Paris Sud University, Versailles Saint Quentin University, INSERM  France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580235956587905","@type":"Researcher","foaf:name":[{"@value":"Marie Metzger"}],"jpcoar:affiliationName":[{"@value":"Centre for Research in Epidemiology and Population Health (CESP), Paris‐Saclay University Paris Sud University, Versailles Saint Quentin University, INSERM  France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580235956587906","@type":"Researcher","foaf:name":[{"@value":"Aghiles Hamroun"}],"jpcoar:affiliationName":[{"@value":"Centre for Research in Epidemiology and Population Health (CESP), Paris‐Saclay University Paris Sud University, Versailles Saint Quentin University, INSERM  France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580235956587912","@type":"Researcher","foaf:name":[{"@value":"Maurice Laville"}],"jpcoar:affiliationName":[{"@value":"Nephrology Department Lyon Sud Hospital  Pierre Benite France"},{"@value":"Lyon University, INSERM U1060  CarMeN Pierre Benite France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580235956587776","@type":"Researcher","foaf:name":[{"@value":"Solène M. Laville"}],"jpcoar:affiliationName":[{"@value":"Centre for Research in Epidemiology and Population Health (CESP), Paris‐Saclay University Paris Sud University, Versailles Saint Quentin University, INSERM  France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580235956587908","@type":"Researcher","foaf:name":[{"@value":"Luc Frimat"}],"jpcoar:affiliationName":[{"@value":"Nephrology Department Nancy University Hospital  Vandoeuvre‐lès‐Nancy France"},{"@value":"Laboratory, EA4360 Lorraine University  Nancy France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580235956587904","@type":"Researcher","foaf:name":[{"@value":"Roberto Pecoits‐Filho"}],"jpcoar:affiliationName":[{"@value":"Arbor Research Collaborative for Health  Ann Arbor Michigan USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580235956587909","@type":"Researcher","foaf:name":[{"@value":"Denis Fouque"}],"jpcoar:affiliationName":[{"@value":"Nephrology Department, Centre Hospitalier Lyon Sud Université de Lyon  Carmen Pierre‐Bénite France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580235956587911","@type":"Researcher","foaf:name":[{"@value":"Ziad A. Massy"}],"jpcoar:affiliationName":[{"@value":"Centre for Research in Epidemiology and Population Health (CESP), Paris‐Saclay University Paris Sud University, Versailles Saint Quentin University, INSERM  France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580235956587913","@type":"Researcher","foaf:name":[{"@value":"Christian Jacquelinet"}],"jpcoar:affiliationName":[{"@value":"Centre for Research in Epidemiology and Population Health (CESP), Paris‐Saclay University Paris Sud University, Versailles Saint Quentin University, INSERM  France"},{"@value":"Biomedecine Agency  Saint Denis La Plaine France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580235956587910","@type":"Researcher","foaf:name":[{"@value":"Bénédicte Stengel"}],"jpcoar:affiliationName":[{"@value":"Centre for Research in Epidemiology and Population Health (CESP), Paris‐Saclay University Paris Sud University, Versailles Saint Quentin University, INSERM  France"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1891146593268547859","@type":"Researcher","foaf:name":[{"@value":"CHU Amiens-Picardie"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547857","@type":"Researcher","foaf:name":[{"@value":"Université de Picardie Jules Verne (UPJV)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544842","@type":"Researcher","foaf:name":[{"@value":"Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 (MP3CV) ; Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547843","@type":"Researcher","foaf:name":[{"@value":"Chronic Kidney Disease - Réseau Epidémiologie et Information en Néphrologie (CKD REIN) ; Institut National de la Santé et de la Recherche Médicale (INSERM)"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547842","@type":"Researcher","foaf:name":[{"@value":"Centre de recherche en épidémiologie et santé des populations (CESP) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547858","@type":"Researcher","foaf:name":[{"@value":"Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS) ; Hospices Civils de Lyon (HCL)"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547860","@type":"Researcher","foaf:name":[{"@value":"Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN) ; Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon) ; Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547850","@type":"Researcher","foaf:name":[{"@value":"Service de Néphrologie [CHRU Nancy] ; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547849","@type":"Researcher","foaf:name":[{"@value":"Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC) ; Université de Lorraine (UL)"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547865","@type":"Researcher","foaf:name":[{"@value":"Arbor Research Collaborative for Health"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547844","@type":"Researcher","foaf:name":[{"@value":"Université de Lyon"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547845","@type":"Researcher","foaf:name":[{"@value":"Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN) ; Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon) ; Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL)"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547853","@type":"Researcher","foaf:name":[{"@value":"Agence de la biomédecine [Saint-Denis la Plaine]"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547851","@type":"Researcher","foaf:name":[{"@value":"ANR-10-COHO-0001,CKD-REIN,Maladie Rénale Chronique - Réseau Epidémiologie et Information en Néphrologie(2010)"}]},{"@id":"https://cir.nii.ac.jp/crid/1891146593268547864","@type":"Researcher","foaf:name":[{"@value":"Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV) ; Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544845","@type":"Researcher","foaf:name":[{"@value":"Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544848","@type":"Researcher","foaf:name":[{"@value":"Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544834","@type":"Researcher","foaf:name":[{"@value":"Institut National de la Santé et de la Recherche Médicale (INSERM)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544847","@type":"Researcher","foaf:name":[{"@value":"Centre de recherche en épidémiologie et santé des populations (CESP)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544838","@type":"Researcher","foaf:name":[{"@value":"Centre Hospitalier Lyon Sud CHU - HCL (CHLS)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544835","@type":"Researcher","foaf:name":[{"@value":"Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544836","@type":"Researcher","foaf:name":[{"@value":"Hospices Civils de Lyon (HCL)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544840","@type":"Researcher","foaf:name":[{"@value":"Chronic Kidney Disease - Réseau Epidémiologie et Information en Néphrologie (CKD REIN)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544846","@type":"Researcher","foaf:name":[{"@value":"Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544833","@type":"Researcher","foaf:name":[{"@value":"Université Claude Bernard Lyon 1 (UCBL)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544843","@type":"Researcher","foaf:name":[{"@value":"Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544837","@type":"Researcher","foaf:name":[{"@value":"Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544849","@type":"Researcher","foaf:name":[{"@value":"Service de Néphrologie CHRU Nancy"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544841","@type":"Researcher","foaf:name":[{"@value":"Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544844","@type":"Researcher","foaf:name":[{"@value":"Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544832","@type":"Researcher","foaf:name":[{"@value":"Université de Lorraine (UL)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892555066383544839","@type":"Researcher","foaf:name":[{"@value":"Agence de la biomédecine Saint-Denis la Plaine"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03065251"},{"@type":"EISSN","@value":"13652125"}],"prism:publicationName":[{"@value":"British Journal of Clinical Pharmacology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2021-01-19","prism:volume":"87","prism:number":"7","prism:startingPage":"2967","prism:endingPage":"2976"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.14713"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/bcp.14713"},{"@id":"https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.14713"}],"createdAt":"2020-12-24","modifiedAt":"2023-08-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=pharmacoepidemiology","dc:title":"pharmacoepidemiology"},{"@id":"https://cir.nii.ac.jp/all?q=renal%20risk","dc:title":"renal risk"},{"@id":"https://cir.nii.ac.jp/all?q=%5BSDV%5DLife%20Sciences%20%5Bq-bio%5D","dc:title":"[SDV]Life Sciences [q-bio]"},{"@id":"https://cir.nii.ac.jp/all?q=Proton%20Pump%20Inhibitors","dc:title":"Proton Pump Inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Cohort%20Studies","dc:title":"Cohort Studies"},{"@id":"https://cir.nii.ac.jp/all?q=acute%20kidney%20injury","dc:title":"acute kidney injury"},{"@id":"https://cir.nii.ac.jp/all?q=Risk%20Factors","dc:title":"Risk Factors"},{"@id":"https://cir.nii.ac.jp/all?q=616","dc:title":"616"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney%20Failure,%20Chronic","dc:title":"Kidney Failure, Chronic"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=proton%20pump%20inhibitors","dc:title":"proton pump inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Renal%20Insufficiency,%20Chronic","dc:title":"Renal Insufficiency, Chronic"},{"@id":"https://cir.nii.ac.jp/all?q=chronic%20kidney%20disease","dc:title":"chronic kidney disease"},{"@id":"https://cir.nii.ac.jp/all?q=Glomerular%20Filtration%20Rate","dc:title":"Glomerular Filtration Rate"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050860687400576768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Use of proton pump inhibitors and macrolide antibiotics and risk of acute kidney injury: a self-controlled case series study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430186948864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Baseline Characteristics of the DISCOVER CKD Prospective Cohort"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/bcp.14713"},{"@type":"OPENAIRE","@value":"doi_dedup___::fe49cc6e4694c05a89d72694ec98d146"},{"@type":"CROSSREF","@value":"10.1007/s12325-024-03028-z_references_DOI_HIhGrmGgM4He8e59pGXZQDTiPmC"},{"@type":"CROSSREF","@value":"10.1186/s12882-022-03008-x_references_DOI_HIhGrmGgM4He8e59pGXZQDTiPmC"}]}