{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360580236809092224.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/scitranslmed.abm3302"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/scitranslmed.abm3302"}}],"dc:title":[{"@value":"Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Although mRNA vaccines encoding the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevent COVID-19, the emergence of new viral variants jeopardizes their efficacy. Here, we assessed the immunogenicity and protective activity of historical (mRNA-1273, designed for Wuhan-1 spike protein) or modified (mRNA-1273.351, designed for B.1.351 spike protein) Moderna mRNA vaccines in 129S2 and K18-hACE2 mice. Mice were immunized with either high-dose or low-dose formulations of the mRNA vaccines, where low-dose vaccination modeled suboptimal immune responses. Immunization with formulations at either dose induced neutralizing antibodies in serum against ancestral SARS-CoV-2 WA1/2020 and several virus variants, although serum titers were lower against the B.1.617.2 (Delta) virus. Protection against weight loss and lung pathology was observed with all high-dose vaccines against all viruses. However, low-dose formulations of the vaccines, which produced lower magnitude antibody and T cell responses, showed breakthrough lung infections with B.1.617.2 and development of pneumonia in K18-hACE2 mice. Thus, in individuals with reduced immunity after mRNA vaccination, breakthrough infection and disease may occur with some SARS-CoV-2 variants.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380580236809092367","@type":"Researcher","foaf:name":[{"@value":"Baoling Ying"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092369","@type":"Researcher","foaf:name":[{"@value":"Bradley Whitener"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092365","@type":"Researcher","foaf:name":[{"@value":"Laura A. VanBlargan"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092355","@type":"Researcher","foaf:name":[{"@value":"Ahmed O. Hassan"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092352","@type":"Researcher","foaf:name":[{"@value":"Swathi Shrihari"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092360","@type":"Researcher","foaf:name":[{"@value":"Chieh-Yu Liang"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092368","@type":"Researcher","foaf:name":[{"@value":"Courtney E. Karl"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"@value":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092370","@type":"Researcher","foaf:name":[{"@value":"Samantha Mackin"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092361","@type":"Researcher","foaf:name":[{"@value":"Rita E. Chen"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092366","@type":"Researcher","foaf:name":[{"@value":"Natasha M. Kafai"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092363","@type":"Researcher","foaf:name":[{"@value":"Samuel H. Wilks"}],"jpcoar:affiliationName":[{"@value":"Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092357","@type":"Researcher","foaf:name":[{"@value":"Derek J. Smith"}],"jpcoar:affiliationName":[{"@value":"Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092371","@type":"Researcher","foaf:name":[{"@value":"Juan Manuel Carreño"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092362","@type":"Researcher","foaf:name":[{"@value":"Gagandeep Singh"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092359","@type":"Researcher","foaf:name":[{"@value":"Florian Krammer"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092354","@type":"Researcher","foaf:name":[{"@value":"Andrea Carfi"}],"jpcoar:affiliationName":[{"@value":"Moderna Inc., Cambridge, MA 02139, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092356","@type":"Researcher","foaf:name":[{"@value":"Sayda M. Elbashir"}],"jpcoar:affiliationName":[{"@value":"Moderna Inc., Cambridge, MA 02139, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092364","@type":"Researcher","foaf:name":[{"@value":"Darin K. Edwards"}],"jpcoar:affiliationName":[{"@value":"Moderna Inc., Cambridge, MA 02139, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092353","@type":"Researcher","foaf:name":[{"@value":"Larissa B. Thackray"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236809092358","@type":"Researcher","foaf:name":[{"@value":"Michael S. Diamond"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"@value":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"@value":"The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19466234"},{"@type":"EISSN","@value":"19466242"}],"prism:publicationName":[{"@value":"Science Translational Medicine"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2022-02-02","prism:volume":"14","prism:number":"630","prism:startingPage":"eabm3302"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/scitranslmed.abm3302"}],"createdAt":"2022-02-02","modifiedAt":"2024-01-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360580232150677632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Saturation time of exposure interval for cross-neutralization response to SARS-CoV-2: Implications for vaccine dose interval"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1126/scitranslmed.abm3302"},{"@type":"CROSSREF","@value":"10.1016/j.isci.2023.106694_references_DOI_NDWCQImi3j3T3HlArA80AuLJzx1"}]}