{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360580236933604352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41567-022-01520-3"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41567-022-01520-3.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41567-022-01520-3"}}],"dc:title":[{"@value":"Tumour irradiation in mice with a laser-accelerated proton beam"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Recent oncological studies identified beneficial properties of radiation applied at ultrahigh dose rates, several orders of magnitude higher than the clinical standard of the order of Gy min<jats:sup>–1</jats:sup>. Sources capable of providing these ultrahigh dose rates are under investigation. Here we show that a stable, compact laser-driven proton source with energies greater than 60 MeV enables radiobiological in vivo studies. We performed a pilot irradiation study on human tumours in a mouse model, showing the concerted preparation of mice and laser accelerator, dose-controlled, tumour-conform irradiation using a laser-driven as well as a clinical reference proton source, and the radiobiological evaluation of irradiated and unirradiated mice for radiation-induced tumour growth delay. The prescribed homogeneous dose of 4 Gy was precisely delivered at the laser-driven source. The results demonstrate a complete laser-driven proton research platform for diverse user-specific small animal models, able to deliver tunable single-shot doses up to around 20 Gy to millimetre-scale volumes on nanosecond timescales, equivalent to around 10<jats:sup>9</jats:sup> Gy s<jats:sup>–1</jats:sup>, spatially homogenized and tailored to the sample. The platform provides a unique infrastructure for translational research with protons at ultrahigh dose rates.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380580236933604357","@type":"Researcher","foaf:name":[{"@value":"Florian Kroll"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604483","@type":"Researcher","foaf:name":[{"@value":"Florian-Emanuel Brack"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604482","@type":"Researcher","foaf:name":[{"@value":"Constantin Bernert"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604485","@type":"Researcher","foaf:name":[{"@value":"Stefan Bock"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604373","@type":"Researcher","foaf:name":[{"@value":"Elisabeth Bodenstein"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604372","@type":"Researcher","foaf:name":[{"@value":"Kerstin Brüchner"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604354","@type":"Researcher","foaf:name":[{"@value":"Thomas E. Cowan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604362","@type":"Researcher","foaf:name":[{"@value":"Lennart Gaus"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604480","@type":"Researcher","foaf:name":[{"@value":"René Gebhardt"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604358","@type":"Researcher","foaf:name":[{"@value":"Uwe Helbig"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604484","@type":"Researcher","foaf:name":[{"@value":"Leonhard Karsch"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604365","@type":"Researcher","foaf:name":[{"@value":"Thomas Kluge"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604352","@type":"Researcher","foaf:name":[{"@value":"Stephan Kraft"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604366","@type":"Researcher","foaf:name":[{"@value":"Mechthild Krause"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604353","@type":"Researcher","foaf:name":[{"@value":"Elisabeth Lessmann"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604374","@type":"Researcher","foaf:name":[{"@value":"Umar Masood"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604360","@type":"Researcher","foaf:name":[{"@value":"Sebastian Meister"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604359","@type":"Researcher","foaf:name":[{"@value":"Josefine Metzkes-Ng"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604371","@type":"Researcher","foaf:name":[{"@value":"Alexej Nossula"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604361","@type":"Researcher","foaf:name":[{"@value":"Jörg Pawelke"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604375","@type":"Researcher","foaf:name":[{"@value":"Jens Pietzsch"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604367","@type":"Researcher","foaf:name":[{"@value":"Thomas Püschel"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604481","@type":"Researcher","foaf:name":[{"@value":"Marvin Reimold"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604355","@type":"Researcher","foaf:name":[{"@value":"Martin Rehwald"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604368","@type":"Researcher","foaf:name":[{"@value":"Christian Richter"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604363","@type":"Researcher","foaf:name":[{"@value":"Hans-Peter Schlenvoigt"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604369","@type":"Researcher","foaf:name":[{"@value":"Ulrich Schramm"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604370","@type":"Researcher","foaf:name":[{"@value":"Marvin E. P. Umlandt"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604376","@type":"Researcher","foaf:name":[{"@value":"Tim Ziegler"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604356","@type":"Researcher","foaf:name":[{"@value":"Karl Zeil"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580236933604364","@type":"Researcher","foaf:name":[{"@value":"Elke Beyreuther"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"17452473"},{"@type":"EISSN","@value":"17452481"}],"prism:publicationName":[{"@value":"Nature Physics"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2022-03","prism:volume":"18","prism:number":"3","prism:startingPage":"316","prism:endingPage":"322"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41567-022-01520-3.pdf"},{"@id":"https://www.nature.com/articles/s41567-022-01520-3"}],"createdAt":"2022-03-15","modifiedAt":"2022-10-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360017282208148608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enhanced ion acceleration from transparency-driven foils demonstrated at two ultraintense laser facilities"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390757299456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Optimum design of double-layer target for proton acceleration by ultrahigh intense femtosecond lasers considering relativistic rising edge"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757205134848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Spectral-temporal measurement capabilities of third-order correlators"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302866858858496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evaluation of the spatial resolution of Gafchromic™ HD-V2 radiochromic film characterized by the modulation transfer function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306904400069760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ion acceleration with an intense short-pulse laser and large-area suspended graphene in an extremely thin target regime"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340520512640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Deep learning approaches for modeling laser-driven proton beams via phase-stable acceleration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869856025457152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Laser-driven high-energy proton beams from cascaded acceleration regimes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390305256686650880","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of an X-Ray Diagnostic Method for High-Density Plasmas for Optimizing Laser-Driven Heavy Ion Acceleration"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/s41567-022-01520-3"},{"@type":"CROSSREF","@value":"10.1038/s41377-023-01083-9_references_DOI_Kyt4incRI0qxaUAIVxpQZZEeCM8"},{"@type":"CROSSREF","@value":"10.1103/physreve.108.035205_references_DOI_Kyt4incRI0qxaUAIVxpQZZEeCM8"},{"@type":"CROSSREF","@value":"10.2184/lsj.51.9_590_references_DOI_Kyt4incRI0qxaUAIVxpQZZEeCM8"},{"@type":"CROSSREF","@value":"10.1364/oe.475575_references_DOI_Kyt4incRI0qxaUAIVxpQZZEeCM8"},{"@type":"CROSSREF","@value":"10.1063/5.0160754_references_DOI_Kyt4incRI0qxaUAIVxpQZZEeCM8"},{"@type":"CROSSREF","@value":"10.1016/j.hedp.2025.101195_references_DOI_Kyt4incRI0qxaUAIVxpQZZEeCM8"},{"@type":"CROSSREF","@value":"10.1063/5.0178238_references_DOI_Kyt4incRI0qxaUAIVxpQZZEeCM8"},{"@type":"CROSSREF","@value":"10.1038/s41567-024-02505-0_references_DOI_Kyt4incRI0qxaUAIVxpQZZEeCM8"}]}