{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360580237193824512.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1158/0008-5472.can-18-3437"}},{"identifier":{"@type":"URI","@value":"https://aacrjournals.org/cancerres/article-pdf/79/6/1044/2787947/1044.pdf"}}],"dc:title":[{"@value":"Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Senescence, a durable form of growth arrest, represents a primary response to numerous anticancer therapies. Although the paradigm that senescence is “irreversible” has largely withstood the findings of tumor cell recovery from what has been termed “pseudo-senescence” or “senescence-like arrest,” a review of the literature suggests that therapy-induced senescence in tumor cells is not obligatorily a permanent cell fate. Consequently, we propose that senescence represents one avenue whereby tumor cells evade the direct cytotoxic impact of therapy, thereby allowing for prolonged survival in a dormant state, with the potential to recover self-renewal capacity and contribute to disease recurrence.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380580237193824512","@type":"Researcher","foaf:name":[{"@value":"Tareq Saleh"}],"jpcoar:affiliationName":[{"@value":"1Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa, Jordan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580237193824513","@type":"Researcher","foaf:name":[{"@value":"Liliya Tyutyunyk-Massey"}],"jpcoar:affiliationName":[{"@value":"2Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, Virginia."},{"@value":"3Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia."}]},{"@id":"https://cir.nii.ac.jp/crid/1380580237193824514","@type":"Researcher","foaf:name":[{"@value":"David A. Gewirtz"}],"jpcoar:affiliationName":[{"@value":"2Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, Virginia."},{"@value":"3Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00085472"},{"@type":"EISSN","@value":"15387445"}],"prism:publicationName":[{"@value":"Cancer Research"}],"dc:publisher":[{"@value":"American Association for Cancer Research (AACR)"}],"prism:publicationDate":"2019-03-15","prism:volume":"79","prism:number":"6","prism:startingPage":"1044","prism:endingPage":"1046"},"reviewed":"false","url":[{"@id":"https://aacrjournals.org/cancerres/article-pdf/79/6/1044/2787947/1044.pdf"}],"createdAt":"2019-02-25","modifiedAt":"2022-06-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050863008862774400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Therapeutic strategies targeting cellular senescence for cancer and other diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390765826048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298754845159040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The role of cellular senescence and SASP in tumour microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905173894912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Therapeutic Senolysis of Axitinib-Induced Senescent Human Lung Cancer Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340521675008","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chemo-senolytic therapeutic potential against angiosarcoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865814750716032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chemo-Senolytic Therapeutic Potential against Angiosarcoma"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1158/0008-5472.can-18-3437"},{"@type":"CROSSREF","@value":"10.1038/s41698-023-00486-6_references_DOI_MTTeiK7UwdrOwZKsA7aqNr8lt7y"},{"@type":"CROSSREF","@value":"10.1111/febs.16381_references_DOI_MTTeiK7UwdrOwZKsA7aqNr8lt7y"},{"@type":"CROSSREF","@value":"10.3390/cancers16162782_references_DOI_MTTeiK7UwdrOwZKsA7aqNr8lt7y"},{"@type":"CROSSREF","@value":"10.1093/jb/mvae015_references_DOI_MTTeiK7UwdrOwZKsA7aqNr8lt7y"},{"@type":"CROSSREF","@value":"10.1101/2023.10.19.563192_references_DOI_MTTeiK7UwdrOwZKsA7aqNr8lt7y"},{"@type":"CROSSREF","@value":"10.1016/j.jid.2024.03.026_references_DOI_MTTeiK7UwdrOwZKsA7aqNr8lt7y"}]}