{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360580239679835008.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/jaha.115.002742"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/JAHA.115.002742"}}],"dc:title":[{"@value":"Short‐Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background</jats:title>\n            <jats:p xml:lang=\"en\">Short‐term exposure to elevated air pollution has been associated with higher risk of acute cardiovascular diseases, with systemic oxidative stress induced by air pollution hypothesized as an important underlying mechanism. However, few community‐based studies have assessed this association.</jats:p>\n          </jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results</jats:title>\n            <jats:p xml:lang=\"en\">\n              Two thousand thirty‐five Framingham Offspring Cohort participants living within 50 km of the Harvard Boston Supersite who were not current smokers were included. We assessed circulating biomarkers of oxidative stress including blood myeloperoxidase at the seventh examination (1998–2001) and urinary creatinine‐indexed 8‐epi‐prostaglandin F\n              <jats:sub>2α</jats:sub>\n              (8‐epi‐\n              <jats:styled-content style=\"fixed-case\">PGF</jats:styled-content>\n              <jats:sub>2α</jats:sub>\n              ) at the seventh and eighth (2005–2008) examinations. We measured fine particulate matter (\n              <jats:styled-content style=\"fixed-case\">PM</jats:styled-content>\n              <jats:sub>2.5</jats:sub>\n              ), black carbon, sulfate, nitrogen oxides, and ozone at the Supersite and calculated 1‐, 2‐, 3‐, 5‐, and 7‐day moving averages of each pollutant. Measured myeloperoxidase and 8‐epi‐\n              <jats:styled-content style=\"fixed-case\">PGF</jats:styled-content>\n              <jats:sub>2α</jats:sub>\n              were log\n              <jats:sub>e</jats:sub>\n              transformed. We used linear regression models and linear mixed‐effects models with random intercepts for myeloperoxidase and indexed 8‐epi‐\n              <jats:styled-content style=\"fixed-case\">PGF</jats:styled-content>\n              <jats:sub>2α</jats:sub>\n              , respectively. Models were adjusted for demographic variables, individual‐ and area‐level measures of socioeconomic position, clinical and lifestyle factors, weather, and temporal trend. We found positive associations of\n              <jats:styled-content style=\"fixed-case\">PM</jats:styled-content>\n              <jats:sub>2.5</jats:sub>\n              and black carbon with myeloperoxidase across multiple moving averages. Additionally, 2‐ to 7‐day moving averages of\n              <jats:styled-content style=\"fixed-case\">PM</jats:styled-content>\n              <jats:sub>2.5</jats:sub>\n              and sulfate were consistently positively associated with 8‐epi‐\n              <jats:styled-content style=\"fixed-case\">PGF</jats:styled-content>\n              <jats:sub>2α</jats:sub>\n              . Stronger positive associations of black carbon and sulfate with myeloperoxidase were observed among participants with diabetes than in those without.\n            </jats:p>\n          </jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions</jats:title>\n            <jats:p xml:lang=\"en\">Our community‐based investigation supports an association of select markers of ambient air pollution with circulating biomarkers of oxidative stress.</jats:p>\n          </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380580239679835013","@type":"Researcher","foaf:name":[{"@value":"Wenyuan Li"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA"},{"@value":"Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835012","@type":"Researcher","foaf:name":[{"@value":"Elissa H. Wilker"}],"jpcoar:affiliationName":[{"@value":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA"},{"@value":"Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835015","@type":"Researcher","foaf:name":[{"@value":"Kirsten S. Dorans"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA"},{"@value":"Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835019","@type":"Researcher","foaf:name":[{"@value":"Mary B. Rice"}],"jpcoar:affiliationName":[{"@value":"Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"},{"@value":"Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835011","@type":"Researcher","foaf:name":[{"@value":"Joel Schwartz"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA"},{"@value":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835018","@type":"Researcher","foaf:name":[{"@value":"Brent A. Coull"}],"jpcoar:affiliationName":[{"@value":"Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835017","@type":"Researcher","foaf:name":[{"@value":"Petros Koutrakis"}],"jpcoar:affiliationName":[{"@value":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835020","@type":"Researcher","foaf:name":[{"@value":"Diane R. Gold"}],"jpcoar:affiliationName":[{"@value":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835014","@type":"Researcher","foaf:name":[{"@value":"John F. Keaney"}],"jpcoar:affiliationName":[{"@value":"Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835008","@type":"Researcher","foaf:name":[{"@value":"Honghuang Lin"}],"jpcoar:affiliationName":[{"@value":"National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA"},{"@value":"Preventive Medicine and Cardiovascular Medicine Sections, Department of Medicine, Boston University School of Medicine, Boston, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835016","@type":"Researcher","foaf:name":[{"@value":"Ramachandran S. Vasan"}],"jpcoar:affiliationName":[{"@value":"National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA"},{"@value":"Preventive Medicine and Cardiovascular Medicine Sections, Department of Medicine, Boston University School of Medicine, Boston, MA"},{"@value":"Department of Epidemiology, Boston University School of Public Health, Boston, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835010","@type":"Researcher","foaf:name":[{"@value":"Emelia J. Benjamin"}],"jpcoar:affiliationName":[{"@value":"National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA"},{"@value":"Preventive Medicine and Cardiovascular Medicine Sections, Department of Medicine, Boston University School of Medicine, Boston, MA"},{"@value":"Department of Epidemiology, Boston University School of Public Health, Boston, MA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580239679835009","@type":"Researcher","foaf:name":[{"@value":"Murray A. Mittleman"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA"},{"@value":"Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20479980"}],"prism:publicationName":[{"@value":"Journal of the American Heart Association"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2016-05-06","prism:volume":"5","prism:number":"5","prism:startingPage":"e002742"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/JAHA.115.002742"}],"createdAt":"2016-04-29","modifiedAt":"2024-05-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360580230637243136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Preventive Effect of Epigallocatechin Gallate, the Main Component of Green Tea, on Acute Lung Injury Caused by Air Pollutants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588381046669568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Metallothionein, an endogenous antioxidant protein, protects against acute lung injury caused by air pollutants"}]},{"@id":"https://cir.nii.ac.jp/crid/1390862467718362752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association between short-term exposure to ambient air pollutants and biomarkers indicative of inflammation and oxidative stress: a cross-sectional study using KoGES-HEXA data"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/jaha.115.002742"},{"@type":"CROSSREF","@value":"10.1265/ehpm.23-00199_references_DOI_OjCtep790zyfIWGZw4DbDlvKL3b"},{"@type":"CROSSREF","@value":"10.3390/biom12091196_references_DOI_OjCtep790zyfIWGZw4DbDlvKL3b"},{"@type":"CROSSREF","@value":"10.1016/j.biopha.2025.117965_references_DOI_OjCtep790zyfIWGZw4DbDlvKL3b"}]}