{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360580240126961152.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/jnci/djaa143"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/jnci/advance-article-pdf/doi/10.1093/jnci/djaa143/36246878/djaa143.pdf"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/jnci/article-pdf/113/5/580/37798495/djaa143.pdf"}}],"dc:title":[{"@value":"Serum Concentrations of Per- and Polyfluoroalkyl Substances and Risk of Renal Cell Carcinoma"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>Per- and polyfluoroalkyl substances (PFAS) are highly persistent chemicals that have been detected in the serum of over 98% of the US population. Studies among highly exposed individuals suggest an association with perfluorooctanoic acid (PFOA) exposure and kidney cancer. It remains unclear whether PFOA or other PFAS are renal carcinogens or if they influence risk of renal cell carcinoma (RCC) at concentrations observed in the general population.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>We measured prediagnostic serum concentrations of PFOA and 7 additional PFAS in 324 RCC cases and 324 individually matched controls within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Multivariable conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CIs) relating serum PFAS concentrations and RCC risk. Individual PFAS were modeled continuously (log2-transformed) and categorically, with adjustment for kidney function and additional potential confounders. All statistical tests were 2-sided.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>We observed a positive association with RCC risk for PFOA (doubling in serum concentration, ORcontinuous = 1.71, 95% CI = 1.23 to 2.37, P = .002) and a greater than twofold increased risk among those in the highest quartile vs the lowest (OR = 2.63, 95% CI = 1.33 to 5.20, Ptrend = .007). The association with PFOA was similar after adjustment for other PFAS (ORcontinuous = 1.68, 95% CI = 1.07 to 2.63, P = .02) and remained apparent in analyses restricted to individuals without evidence of diminished kidney function and in cases diagnosed 8 or more years after phlebotomy.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>Our findings add substantially to the weight of evidence that PFOA is a renal carcinogen and may have important public health implications for the many individuals exposed to this ubiquitous and highly persistent chemical.</jats:p>\n               </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380580240126961160","@type":"Researcher","foaf:name":[{"@value":"Joseph J Shearer"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240126961153","@type":"Researcher","foaf:name":[{"@value":"Catherine L Callahan"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240126961156","@type":"Researcher","foaf:name":[{"@value":"Antonia M Calafat"}],"jpcoar:affiliationName":[{"@value":"National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240126961158","@type":"Researcher","foaf:name":[{"@value":"Wen-Yi Huang"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240126961155","@type":"Researcher","foaf:name":[{"@value":"Rena R Jones"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240126961162","@type":"Researcher","foaf:name":[{"@value":"Venkata S Sabbisetti"}],"jpcoar:affiliationName":[{"@value":"Brigham and Women's Hospital, Harvard Institutes of Medicine, Boston, MA, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240126961154","@type":"Researcher","foaf:name":[{"@value":"Neal D Freedman"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240126961161","@type":"Researcher","foaf:name":[{"@value":"Joshua N Sampson"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240126961152","@type":"Researcher","foaf:name":[{"@value":"Debra T Silverman"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240126961157","@type":"Researcher","foaf:name":[{"@value":"Mark P Purdue"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240126961159","@type":"Researcher","foaf:name":[{"@value":"Jonathan N Hofmann"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278874"},{"@type":"EISSN","@value":"14602105"}],"prism:publicationName":[{"@value":"JNCI: Journal of the National Cancer Institute"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2020-09-18","prism:volume":"113","prism:number":"5","prism:startingPage":"580","prism:endingPage":"587"},"reviewed":"false","url":[{"@id":"http://academic.oup.com/jnci/advance-article-pdf/doi/10.1093/jnci/djaa143/36246878/djaa143.pdf"},{"@id":"http://academic.oup.com/jnci/article-pdf/113/5/580/37798495/djaa143.pdf"}],"createdAt":"2020-09-05","modifiedAt":"2021-05-04","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360025430217083008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Plasma perfluoroalkyl substances and breast cancer risk in Brazilian women: a case–control study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340527538560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Perfluorooctanoic acid-induced cell death via the dual roles of ROS-MAPK/ERK signaling in ameloblast-lineage 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Prospective Nested Case-control Study"}]},{"@id":"https://cir.nii.ac.jp/crid/2051996266996506368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Exposure to environmental chemicals and cancer risk : epidemiological evidence from Japanese 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