{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360580240127918848.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/cells9092017"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2073-4409/9/9/2017/pdf"}}],"dc:title":[{"@value":"Aberrant Methylation of LINE-1 Transposable Elements: A Search for Cancer Biomarkers"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Cancer remains one of the main causes of human mortality despite significant progress in its diagnostics and therapy achieved in the past decade. Massive hypomethylation of retrotransposons, in particular LINE-1, is considered a hallmark of most malignant transformations as it results in the reactivation of retroelements and subsequent genomic instability. Accumulating data on LINE-1 aberrant methylation in different tumor types indicates its significant role in cancer initiation and progression. However, direct evidence that LINE-1 activation can be used as a cancer biomarker is still limited. The objective of this review was to critically evaluate the published results regarding the diagnostic/prognostic potential of the LINE-1 methylation status in cancer. Our analysis indicates that LINE-1 hypomethylation is a promising candidate biomarker of cancer development, which, however, needs validation in both clinical and laboratory studies to confirm its applicability to different cancer types and/or stages. As LINE-1 is present in multiple cell-free copies in blood, it has advantages over single-copy genes regarding perspectives of using its methylation status as an epigenetic cancer biomarker for cell-free DNA liquid biopsy.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380580240127918852","@type":"Researcher","foaf:name":[{"@value":"Anastasia A. Ponomaryova"}],"jpcoar:affiliationName":[{"@value":"Cancer Research Institute, Tomsk National Research Medical Center, 634009 Tomsk, Russia"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240127918853","@type":"Researcher","foaf:name":[{"@value":"Elena Y. Rykova"}],"jpcoar:affiliationName":[{"@value":"Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"},{"@value":"Department of Engineering Issues in Ecology, Novosibirsk State Technical University, 630073 Novosibirsk, Russia"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240127918849","@type":"Researcher","foaf:name":[{"@value":"Polina A. Gervas"}],"jpcoar:affiliationName":[{"@value":"Cancer Research Institute, Tomsk National Research Medical Center, 634009 Tomsk, Russia"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240127918850","@type":"Researcher","foaf:name":[{"@value":"Nadezhda V. Cherdyntseva"}],"jpcoar:affiliationName":[{"@value":"Cancer Research Institute, Tomsk National Research Medical Center, 634009 Tomsk, Russia"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240127918851","@type":"Researcher","foaf:name":[{"@value":"Ilgar Z. Mamedov"}],"jpcoar:affiliationName":[{"@value":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia"},{"@value":"Central European Institute of Technology, Masaryk University, 625 00 Brno, Czech Republic"},{"@value":"Laboratory of Molecular Pathophysiology, V.I. Kulakov National Medical Research Center for Obsterics, 117997 Moscow, Russia"}]},{"@id":"https://cir.nii.ac.jp/crid/1380580240127918848","@type":"Researcher","foaf:name":[{"@value":"Tatyana L. Azhikina"}],"jpcoar:affiliationName":[{"@value":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20734409"}],"prism:publicationName":[{"@value":"Cells"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2020-09-02","prism:volume":"9","prism:number":"9","prism:startingPage":"2017"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/2073-4409/9/9/2017/pdf"}],"createdAt":"2020-09-02","modifiedAt":"2025-10-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360861707122072704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Methylation profiles of global LINE-1 DNA and the GSTP1 promoter region in children exposed to lead (Pb)"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3390/cells9092017"},{"@type":"CROSSREF","@value":"10.1080/15592294.2022.2123924_references_DOI_7lbVFhm1h0v1KF990ZpwNhp1N1k"}]}