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Different types of stresses, including thermal, mechanical, and hypoxic stresses, can alter the cellular state that accompanies changes in gene expression but not the cellular identity determined by a chromatin state that remains stable throughout life. Some tissues, such as adipose tissue, demonstrate remarkable plasticity and adaptability in response to environmental cues, enabling reversible cellular identity changes; however, the mechanisms underlying these changes are not well understood. We hypothesized that positive and/or negative “Integrators” sense environmental cues and coordinate the epigenetic and transcriptional pathways required for changes in cellular identity. Adverse environmental factors such as pollution disrupt the coordinated control contributing to disease development. Further research based on this hypothesis will reveal how organisms adapt to fluctuating environmental conditions, such as temperature, extracellular matrix stiffness, oxygen, cytokines, and hormonal cues by changing their cellular identities.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380584339760445568","@type":"Researcher","foaf:name":[{"@value":"Hiroki Takahashi"}],"jpcoar:affiliationName":[{"@value":"Division of Molecular Physiology and Metabolism Tohoku University Graduate School of Medicine  Sendai Japan"},{"@value":"Division of Metabolic Medicine Research Center for Advanced Science and Technology The University of Tokyo  Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339760445442","@type":"Researcher","foaf:name":[{"@value":"Ryo Ito"}],"jpcoar:affiliationName":[{"@value":"Division of Molecular Physiology and Metabolism Tohoku University Graduate School of Medicine  Sendai 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