{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360584339777986304.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1096/fj.202202063r"}},{"identifier":{"@type":"URI","@value":"https://faseb.onlinelibrary.wiley.com/doi/pdf/10.1096/fj.202202063R"}},{"identifier":{"@type":"PMID","@value":"37249913"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Insufficient oxygen inhalation during cardiopulmonary resuscitation induces early changes in hemodynamics followed by late and unfavorable systemic responses in post‐cardiac arrest rats"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Cardiac arrest (CA) and concomitant post‐CA syndrome lead to a lethal condition characterized by systemic ischemia–reperfusion injury. Oxygen (O\n                    <jats:sub>2</jats:sub>\n                    ) supply during cardiopulmonary resuscitation (CPR) is the key to success in resuscitation, but sustained hyperoxia can produce toxic effects post CA. However, only few studies have investigated the optimal duration and dosage of O\n                    <jats:sub>2</jats:sub>\n                    administration. Herein, we aimed to determine whether high concentrations of O\n                    <jats:sub>2</jats:sub>\n                    at resuscitation are beneficial or harmful. After rats were resuscitated from the 10‐min asphyxia, mechanical ventilation was restarted at an FIO\n                    <jats:sub>2</jats:sub>\n                    of 1.0 or 0.3. From 10 min after initiating CPR, FIO\n                    <jats:sub>2</jats:sub>\n                    of both groups were maintained at 0.3. Bio‐physiological parameters including O\n                    <jats:sub>2</jats:sub>\n                    consumption (VO\n                    <jats:sub>2</jats:sub>\n                    ) and mRNA gene expression in multiple organs were evaluated. The FIO\n                    <jats:sub>2</jats:sub>\n                    0.3 group decreased VO\n                    <jats:sub>2</jats:sub>\n                    , delayed the time required to achieve peak MAP, lowered ejection fraction (75.1 ± 3.3% and 59.0 ± 5.7% with FIO\n                    <jats:sub>2</jats:sub>\n                    1.0 and 0.3, respectively;\n                    <jats:italic>p</jats:italic>\n                     < .05), and increased blood lactate levels (4.9 ± 0.2 mmol/L and 5.6 ± 0.2 mmol/L, respectively;\n                    <jats:italic>p</jats:italic>\n                     < .05) at 10 min after CPR. FIO\n                    <jats:sub>2</jats:sub>\n                    0.3 group had significant increases in hypoxia‐inducible factor, inflammatory, and apoptosis‐related mRNA gene expression in the brain. Likewise, significant upregulations of hypoxia‐inducible factor and apoptosis‐related gene expression were observed in the FIO\n                    <jats:sub>2</jats:sub>\n                    0.3 group in the heart and lungs. Insufficient O\n                    <jats:sub>2</jats:sub>\n                    supplementation in the first 10 min of resuscitation could prolong ischemia, and may result in unfavorable biological responses 2 h after CA. Faster recovery from the impairment of O\n                    <jats:sub>2</jats:sub>\n                    metabolism might contribute to the improvement of hemodynamics during the early post‐resuscitation phase; therefore, it may be reasonable to provide the maximum feasible O\n                    <jats:sub>2</jats:sub>\n                    concentrations during CPR.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380584339777986314","@type":"Researcher","foaf:name":[{"@value":"Tomoaki Aoki"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986309","@type":"Researcher","foaf:name":[{"@value":"Vanessa Wong"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986315","@type":"Researcher","foaf:name":[{"@value":"Yusuke Endo"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986305","@type":"Researcher","foaf:name":[{"@value":"Kei Hayashida"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986306","@type":"Researcher","foaf:name":[{"@value":"Ryosuke Takegawa"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986310","@type":"Researcher","foaf:name":[{"@value":"Muhammad Shoaib"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986313","@type":"Researcher","foaf:name":[{"@value":"Santiago J. Miyara"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986308","@type":"Researcher","foaf:name":[{"@value":"Rishabh C. Choudhary"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986311","@type":"Researcher","foaf:name":[{"@value":"Tai Yin"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986304","@type":"Researcher","foaf:name":[{"@value":"Kota Saeki"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986307","@type":"Researcher","foaf:name":[{"@value":"Simon C. Robson"}],"jpcoar:affiliationName":[{"@value":"Department of Anesthesia, Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986432","@type":"Researcher","foaf:name":[{"@value":"Lance B. Becker"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"},{"@value":"Department of Emergency Medicine Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health  Hempstead New York USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584339777986312","@type":"Researcher","foaf:name":[{"@value":"Koichiro Shinozaki"}],"jpcoar:affiliationName":[{"@value":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"},{"@value":"Department of Emergency Medicine Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health  Hempstead New York USA"},{"@value":"Department of Emergency & Critical Care Medicine Kindai University Faculty of Medicine  Osaka Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08926638"},{"@type":"EISSN","@value":"15306860"}],"prism:publicationName":[{"@value":"The FASEB Journal"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2023-05-30","prism:volume":"37","prism:number":"7","prism:startingPage":"e23001"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://faseb.onlinelibrary.wiley.com/doi/pdf/10.1096/fj.202202063R"}],"createdAt":"2023-05-30","modifiedAt":"2025-10-28","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Oxygen","dc:title":"Oxygen"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Hemodynamics","dc:title":"Hemodynamics"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Hypoxia","dc:title":"Hypoxia"},{"@id":"https://cir.nii.ac.jp/all?q=Cardiopulmonary%20Resuscitation","dc:title":"Cardiopulmonary Resuscitation"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Heart%20Arrest","dc:title":"Heart Arrest"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040860454239435520","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K19643"},{"@type":"JGN","@value":"JP23K19643"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K19643/"}],"notation":[{"@language":"ja","@value":"心停止蘇生後の呼吸商と転機および活性酸素との関連の研究"},{"@language":"en","@value":"Association of respiratory quotient with reactive oxygen species and outcomes in post-cardiac arrest patients"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144519359616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144583567232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of Arterial Oxygen Tension During In-Hospital Cardiac Arrest With Return of Spontaneous Circulation and Survival"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145221296128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiopulmonary-cerebral resuscitation with 100% oxygen exacerbates neurological dysfunction following nine minutes of normothermic cardiac arrest in dogs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145354252544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The rate of oxygen utilization by cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021395471762176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An Automation System Equivalent to the Douglas Bag Technique Enables Continuous and Repeat Metabolic Measurements in Patients Undergoing Mechanical Ventilation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021395472230528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxygen requirement during cardiopulmonary resuscitation (CPR) to effect return of spontaneous circulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021395472752000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Levosimendan Ameliorates Post-resuscitation Acute Intestinal Microcirculation Dysfunction Partly Independent of its Effects on Systemic Circulation: A Pilot Study on Cardiac Arrest in a Rat Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021396139141632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reducing the duration of 100% oxygen ventilation in the early reperfusion period after cardiopulmonary resuscitation decreases striatal brain damage"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021396139585536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Time to Return of Spontaneous Circulation and Survival: When to Transport in out-of-Hospital Cardiac Arrest?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021396140026496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"2020 International Consensus on First Aid Science With Treatment Recommendations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021396140071552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618634316288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Part 8: Post–Cardiac Arrest Care"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620865036800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Post cardiac arrest hyperoxic resuscitation enhances neuronal vulnerability of the respiratory rhythm generator and some brainstem and spinal cord neuronal pools in the dog"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620907281536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Normoxic Ventilation After Cardiac Arrest Reduces Oxidation of Brain Lipids and Improves Neurological Outcome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294647504338688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association Between Early Hyperoxia Exposure After Resuscitation From Cardiac Arrest and Neurological Disability"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302868762982912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"European Resuscitation Council Guidelines 2021: First aid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302868763624960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ASSESSING SHOCK RESUSCITATION STRATEGIES BY OXYGEN DEBT REPAYMENT"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302868763883520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hyperoxygenation With Cardiopulmonary Resuscitation and Targeted Temperature Management Improves Post–Cardiac Arrest Outcomes in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302868763885440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of Post‐Resuscitation Normoxic Therapy on Oxygen‐Sensitive Oxidative Stress in a Rat Model of Cardiac 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rats"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1096/fj.202202063r"},{"@type":"KAKEN","@value":"PRODUCT-24826708"},{"@type":"OPENAIRE","@value":"doi_dedup___::bdb9b42dfe761409eb506277af29817d"},{"@type":"CROSSREF","@value":"10.1016/j.resplu.2024.100819_references_DOI_7GOk4HaWL6UjeBecpMSx4cDxZ9h"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2024.1362858_references_DOI_7GOk4HaWL6UjeBecpMSx4cDxZ9h"}]}