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Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammation can induce oxidative stress and tissue fibrosis in the ovary. In PCOS, endometriosis, and aging, pro-inflammatory cytokine levels are often elevated in follicular fluids. In women with obesity and PCOS, hyperandrogenemia and insulin resistance induce ovarian chronic low-grade inflammation, thereby disrupting follicular development by increasing oxidative stress. In endometriosis, ovarian endometrioma-derived iron overload can induce chronic inflammation and oxidative stress, leading to ovarian ferroptosis and fibrosis. In inflammatory aging (inflammaging), senescent cells may secrete senescence-associated secretory phenotype factors, causing chronic inflammation and oxidative stress in the ovary. Therefore, controlling chronic low-grade inflammation and fibrosis in the ovary would present a novel therapeutic strategy for improving the follicular microenvironment and minimizing ovarian dysfunction.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801212630656","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80324143"},{"@type":"NRID","@value":"1000080324143"},{"@type":"NRID","@value":"9000364307078"},{"@type":"NRID","@value":"9000257775587"},{"@type":"NRID","@value":"9000408493528"},{"@type":"NRID","@value":"9000016804447"},{"@type":"NRID","@value":"9000411533905"},{"@type":"NRID","@value":"9000404146896"},{"@type":"NRID","@value":"9000408493246"},{"@type":"NRID","@value":"9000364457532"},{"@type":"NRID","@value":"9000022408939"},{"@type":"NRID","@value":"9000023213226"},{"@type":"NRID","@value":"9000257775869"},{"@type":"NRID","@value":"9000023067548"},{"@type":"NRID","@value":"9000023236185"},{"@type":"NRID","@value":"9000023163906"},{"@type":"NRID","@value":"9000023067651"},{"@type":"NRID","@value":"9000412156456"},{"@type":"NRID","@value":"9000387465039"},{"@type":"NRID","@value":"9000020077000"},{"@type":"NRID","@value":"9000403737036"},{"@type":"NRID","@value":"9000408644766"},{"@type":"NRID","@value":"9000411116211"},{"@type":"NRID","@value":"9000018604600"},{"@type":"NRID","@value":"9000364457535"},{"@type":"NRID","@value":"9000408415593"},{"@type":"NRID","@value":"9000409489250"},{"@type":"NRID","@value":"9000367416815"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/orisaka"}],"foaf:name":[{"@value":"Makoto Orisaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801191539328","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90322734"},{"@type":"NRID","@value":"1000090322734"},{"@type":"NRID","@value":"9000403736880"},{"@type":"NRID","@value":"9000002665262"},{"@type":"NRID","@value":"9000023236191"},{"@type":"NRID","@value":"9000023067661"},{"@type":"NRID","@value":"9000018704002"},{"@type":"NRID","@value":"9000403736739"},{"@type":"NRID","@value":"9000406192393"},{"@type":"NRID","@value":"9000403737258"},{"@type":"NRID","@value":"9000408480358"},{"@type":"NRID","@value":"9000019058123"},{"@type":"NRID","@value":"9000307257805"},{"@type":"NRID","@value":"9000403737246"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0195410"}],"foaf:name":[{"@value":"Tetsuya Mizutani"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584341817012914","@type":"Researcher","foaf:name":[{"@value":"Yumiko Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584341817003531","@type":"Researcher","foaf:name":[{"@value":"Aya Shirafuji"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584341817012882","@type":"Researcher","foaf:name":[{"@value":"Chiyo Tamamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584341817012878","@type":"Researcher","foaf:name":[{"@value":"Masayuki Fujita"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326215252480","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90593864"},{"@type":"NRID","@value":"1000090593864"},{"@type":"NRID","@value":"9000406192394"},{"@type":"NRID","@value":"9000410472092"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0149413"}],"foaf:name":[{"@value":"Hideaki Tsuyoshi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380584341817012891","@type":"Researcher","foaf:name":[{"@value":"Yoshio Yoshida"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"16642392"}],"prism:publicationName":[{"@value":"Frontiers in Endocrinology"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2023-12-13","prism:volume":"14"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1324429/full"}],"createdAt":"2023-12-13","modifiedAt":"2023-12-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=endometriosis","dc:title":"endometriosis"},{"@id":"https://cir.nii.ac.jp/all?q=Endocrinology","dc:title":"Endocrinology"},{"@id":"https://cir.nii.ac.jp/all?q=follicular%20microenvironment","dc:title":"follicular microenvironment"},{"@id":"https://cir.nii.ac.jp/all?q=inflammation","dc:title":"inflammation"},{"@id":"https://cir.nii.ac.jp/all?q=aging","dc:title":"aging"},{"@id":"https://cir.nii.ac.jp/all?q=ovarian%20dysfunction","dc:title":"ovarian dysfunction"},{"@id":"https://cir.nii.ac.jp/all?q=polycystic%20ovarian%20syndrome","dc:title":"polycystic ovarian syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=RC648-665","dc:title":"RC648-665"},{"@id":"https://cir.nii.ac.jp/all?q=Diseases%20of%20the%20endocrine%20glands.%20Clinical%20endocrinology","dc:title":"Diseases of the endocrine glands. 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