Vitamin D deficiency promotes intracranial aneurysm rupture

Redi Rahmani, Takeshi Miyamoto, Tetsuro Kimura, Daisuke Kudo, Yoshinobu Kamio, Hiroki Sato, Jacob F Baranoski, Taichi Ikedo, Hiroki Uchikawa, Tomoki Hashimoto, Michael T Lawton, Jinglu Ai

doi:10.1177/0271678x241226750

<jats:p> Intracranial aneurysm rupture causes severe disability and high mortality. Epidemiological studies show a strong association between decreased vitamin D levels and an increase in aneurysm rupture. However, the causality and mechanism remain largely unknown. In this study, we tested whether vitamin D deficiency promotes aneurysm rupture and examined the underlying mechanism for the protective role of vitamin D against the development of aneurysm rupture utilizing a mouse model of intracranial aneurysm. Mice consuming a vitamin D-deficient diet had a higher rupture rate than mice with a regular diet. Vitamin D deficiency increased proinflammatory cytokines in the cerebral arteries. Concurrently, vitamin D receptor knockout mice had a higher rupture rate than the corresponding wild-type littermates. The vitamin D receptors on endothelial and vascular smooth muscle cells, but not on hematopoietic cells, mediated the effect of aneurysm rupture. Our results establish that vitamin D protects against the development of aneurysmal rupture through the vitamin D receptors on vascular endothelial and smooth muscle cells. Vitamin D supplementation may be a viable pharmacologic therapy for preventing aneurysm rupture. </jats:p>

Vitamin D deficiency promotes intracranial aneurysm rupture

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