{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360846641009957504.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.molcel.2012.04.018"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1097276512003401?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1097276512003401?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"22749395"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway"}],"description":[{"notation":[{"@value":"One of the unique characteristics of cellular signaling pathways is that a common signaling pathway can selectively regulate multiple cellular functions of a hormone; however, this selective downstream control through a common signaling pathway is poorly understood. Here we show that the insulin-dependent AKT pathway uses temporal patterns multiplexing for selective regulation of downstream molecules. Pulse and sustained insulin stimulations were simultaneously encoded into transient and sustained AKT phosphorylation, respectively. The downstream molecules, including ribosomal protein S6 kinase (S6K), glucose-6-phosphatase (G6Pase), and glycogen synthase kinase-3β (GSK3β) selectively decoded transient, sustained, and both transient and sustained AKT phosphorylation, respectively. Selective downstream decoding is mediated by the molecules' network structures and kinetics. Our results demonstrate that the AKT pathway can multiplex distinct patterns of blood insulin, such as pulse-like additional and sustained-like basal secretions, and the downstream molecules selectively decode secretion patterns of insulin."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801186152320","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40376603"},{"@type":"NRID","@value":"1000040376603"},{"@type":"CINII_AUTHOR_ID","@value":"DA18691739"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA18691739#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA18691739"},{"@type":"NRID","@value":"9000017713399"},{"@type":"NRID","@value":"9000312843436"},{"@type":"NRID","@value":"9000399771546"},{"@type":"NRID","@value":"9000278498524"},{"@type":"NRID","@value":"9000410651699"},{"@type":"NRID","@value":"9000402138540"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/Hkubota"}],"foaf:name":[{"@value":"Hiroyuki 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Uda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869184312963","@type":"Researcher","foaf:name":[{"@value":"Kanako Watanabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751139388032","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40294219"},{"@type":"NRID","@value":"1000040294219"},{"@type":"NRID","@value":"9000409871306"},{"@type":"NRID","@value":"9000399182807"},{"@type":"NRID","@value":"9000403042691"},{"@type":"NRID","@value":"9000403964045"},{"@type":"NRID","@value":"9000319061348"},{"@type":"NRID","@value":"9000327102557"},{"@type":"NRID","@value":"9000402138553"},{"@type":"NRID","@value":"9000005762098"},{"@type":"NRID","@value":"9000403042564"},{"@type":"NRID","@value":"9000398293069"},{"@type":"NRID","@value":"9000014172876"},{"@type":"NRID","@value":"9000239598942"},{"@type":"NRID","@value":"9000402138688"},{"@type":"NRID","@value":"9000367401794"},{"@type":"NRID","@value":"9000397707115"},{"@type":"NRID","@value":"9000403964046"},{"@type":"NRID","@value":"9000345260185"},{"@type":"NRID","@value":"9000006802922"},{"@type":"NRID","@value":"9000239607574"},{"@type":"NRID","@value":"9000325832238"},{"@type":"NRID","@value":"9000403042553"},{"@type":"NRID","@value":"9000412600219"},{"@type":"NRID","@value":"9000413697939"},{"@type":"NRID","@value":"9000303163894"},{"@type":"NRID","@value":"9000311065780"},{"@type":"NRID","@value":"9000310326334"},{"@type":"NRID","@value":"9000405633808"},{"@type":"NRID","@value":"9000301684885"},{"@type":"NRID","@value":"9000404481317"},{"@type":"NRID","@value":"9000402138543"},{"@type":"NRID","@value":"9000399182726"},{"@type":"NRID","@value":"9000405859493"},{"@type":"NRID","@value":"9000398624239"},{"@type":"NRID","@value":"9000238822439"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0078797"}],"foaf:name":[{"@value":"Wataru Ogawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801198101376","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50273850"},{"@type":"NRID","@value":"1000050273850"},{"@type":"NRID","@value":"9000001770341"},{"@type":"NRID","@value":"9000018807192"},{"@type":"NRID","@value":"9000238282401"},{"@type":"NRID","@value":"9000009096970"},{"@type":"NRID","@value":"9000238411965"},{"@type":"NRID","@value":"9000361223685"},{"@type":"NRID","@value":"9000009345458"},{"@type":"NRID","@value":"9000303638504"},{"@type":"NRID","@value":"9000259303618"},{"@type":"NRID","@value":"9000011192256"},{"@type":"NRID","@value":"9000002736881"},{"@type":"NRID","@value":"9000314059557"},{"@type":"NRID","@value":"9000399771541"},{"@type":"NRID","@value":"9000017711911"},{"@type":"NRID","@value":"9000020308944"},{"@type":"NRID","@value":"9000411031863"},{"@type":"NRID","@value":"9000347074393"},{"@type":"NRID","@value":"9000345345878"},{"@type":"NRID","@value":"9000399348405"},{"@type":"NRID","@value":"9000399771548"},{"@type":"NRID","@value":"9000278498540"},{"@type":"NRID","@value":"9000001737584"},{"@type":"NRID","@value":"9000017118520"},{"@type":"NRID","@value":"9000399836140"},{"@type":"NRID","@value":"9000399221374"},{"@type":"NRID","@value":"9000021697023"},{"@type":"NRID","@value":"9000345227565"},{"@type":"NRID","@value":"9000004898639"},{"@type":"NRID","@value":"9000241873458"},{"@type":"NRID","@value":"9000399221395"},{"@type":"NRID","@value":"9000402476939"},{"@type":"NRID","@value":"9000324987307"},{"@type":"NRID","@value":"9000248206639"},{"@type":"NRID","@value":"9000402138544"},{"@type":"NRID","@value":"9000413887657"},{"@type":"NRID","@value":"9000398132278"},{"@type":"NRID","@value":"9000361223706"},{"@type":"NRID","@value":"9000377394505"},{"@type":"NRID","@value":"9000402586317"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/shinyakuroda"}],"foaf:name":[{"@value":"Shinya Kuroda"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10972765"}],"prism:publicationName":[{"@value":"Molecular Cell"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2012-06","prism:volume":"46","prism:number":"6","prism:startingPage":"820","prism:endingPage":"832"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1097276512003401?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1097276512003401?httpAccept=text/plain"}],"createdAt":"2012-05-24","modifiedAt":"2025-10-22","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Glycogen%20Synthase%20Kinase%203%20beta","dc:title":"Glycogen Synthase Kinase 3 beta"},{"@id":"https://cir.nii.ac.jp/all?q=Ribosomal%20Protein%20S6%20Kinases","dc:title":"Ribosomal Protein S6 Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Biology","dc:title":"Cell Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Glycogen%20Synthase%20Kinase%203","dc:title":"Glycogen Synthase Kinase 3"},{"@id":"https://cir.nii.ac.jp/all?q=Kinetics","dc:title":"Kinetics"},{"@id":"https://cir.nii.ac.jp/all?q=Glucose-6-Phosphatase","dc:title":"Glucose-6-Phosphatase"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Insulin","dc:title":"Insulin"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphorylation","dc:title":"Phosphorylation"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Biology","dc:title":"Molecular Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Proto-Oncogene%20Proteins%20c-akt","dc:title":"Proto-Oncogene Proteins c-akt"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782131640064","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22700310"},{"@type":"JGN","@value":"JP22700310"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700310/"}],"notation":[{"@language":"ja","@value":"インスリン波形の情報処理機構の解明"},{"@language":"en","@value":"Analysis of information processing mechanisms of insulin temporal patterns"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782200324864","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24390234"},{"@type":"JGN","@value":"JP24390234"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390234/"}],"notation":[{"@language":"ja","@value":"ＰＧＣ１α新規アイソフォームの機能解析を通じた運動による代謝改善機構の包括的解析"},{"@language":"en","@value":"Comprehensive analysis of exercise-induced metabolic alteration through the investigation of the function of novels isoforms of PGC1a"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257041294336","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21240025"},{"@type":"JGN","@value":"JP21240025"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21240025/"}],"notation":[{"@language":"ja","@value":"細胞成長を制御するAkt経路のシステム生物学"},{"@language":"en","@value":"Systems biology of AKT signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257469046528","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"11J06435"},{"@type":"JGN","@value":"JP11J06435"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11J06435/"}],"notation":[{"@language":"ja","@value":"インスリンの時間変動による肝細胞の糖放出制御機構の解明:実験と数理モデルでの解析"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001339107133440","@type":"Article","resourceType":"学術雑誌論文(journal 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study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641000678016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Modulation of the cellular content of metabolites in adipocytes by insulin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641727300352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643381151232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656925053568","@type":"Article","resourceType":"学術雑誌論文(journal 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