{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360846641090753024.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.smim.2009.10.002"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1044532309000967?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1044532309000967?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"19939703"}},{"identifier":{"@type":"NAID","@value":"10030922505"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Adjuvant activity mediated by iNKT cells"}],"description":[{"notation":[{"@value":"Invariant natural killer T (iNKT) cells have adjuvant activity due to their ability to produce large amounts of IFN-gamma, which activates other cells in innate and acquired systems, and orchestrates protective immunity. Based on these adjuvant mechanisms, we developed iNKT cell-targeted adjuvant therapy and carried out a phase I/IIa trial on advanced lung cancer patients. The patient group with increased numbers of IFN-gamma-producing cells showed prolonged survival with a median survival time of 31.9 months. Sixty percent of the patients in this group survived for more than 2 years with only a primary treatment and without tumor progression and metastasis."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380284919316687620","@type":"Researcher","foaf:name":[{"@value":"Shinichiro 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Vaccines"},{"@id":"https://cir.nii.ac.jp/all?q=Immunity,%20Innate","dc:title":"Immunity, Innate"},{"@id":"https://cir.nii.ac.jp/all?q=Interferon-gamma","dc:title":"Interferon-gamma"},{"@id":"https://cir.nii.ac.jp/all?q=Adjuvants,%20Immunologic","dc:title":"Adjuvants, Immunologic"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Natural%20Killer%20T-Cells","dc:title":"Natural Killer T-Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Immunotherapy","dc:title":"Immunotherapy"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Metastasis","dc:title":"Neoplasm Metastasis"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782049164160","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20591160"},{"@type":"JGN","@value":"JP20591160"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591160/"}],"notation":[{"@language":"ja","@value":"分子標的療法とNKT細胞療法による複合的免疫療法の造血器悪性腫瘍への応用"},{"@language":"en","@value":"Combined application of molecular-targeted therapy and NKT immunotherapy for hematological malignancy"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782429561728","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17016010"},{"@type":"JGN","@value":"JP17016010"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17016010/"}],"notation":[{"@language":"ja","@value":"活性化NKT 細胞によるがん転移抑制治療"},{"@language":"en","@value":"NKT cell-based immunotherapy for 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