{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360846641759912832.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41598-017-15022-3"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-017-15022-3"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-017-15022-3.pdf"}},{"identifier":{"@type":"PMID","@value":"29511226"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Anti-inflammatory and anti-fibrotic effects of intravenous adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumonia"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Adipose-derived stem cells (AdSCs) have recently been considered a useful treatment tool for autoimmune disease because of their anti-inflammatory and immunosuppressive effects. We investigated the therapeutic effect of intravenous AdSC transplantation in a mouse model of bleomycin-induced lung injury. AdSCs accumulated in the pulmonary interstitium and inhibited both inflammation and fibrosis in the lung, markedly improving the survival rate of mice with bleomycin-induced lung injury in a cell number-dependent manner. AdSCs inhibited the production of pro-inflammatory cytokines such as TNF-α and IL-12 in activated macrophages, and AdSCs also induced the apoptosis of activated macrophages. AdSCs inhibited the differentiation and proliferation of Th2-type mCD4+ T cells but promoted the differentiation and proliferation of regulatory T cells, suggesting that the phenotypic conversion of T cells may be one of the mechanisms for the anti-inflammatory effect of AdSCs on pulmonary fibrosis. These findings suggest that intravenous AdSCs could be a promising treatment for patients with interstitial pneumonia.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326236121984","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80411362"},{"@type":"NRID","@value":"1000080411362"},{"@type":"NRID","@value":"9000363353928"},{"@type":"NRID","@value":"9000412247313"},{"@type":"NRID","@value":"9000259332870"},{"@type":"NRID","@value":"9000257905167"},{"@type":"NRID","@value":"9000411540540"},{"@type":"NRID","@value":"9000410916869"},{"@type":"NRID","@value":"9000021892972"},{"@type":"NRID","@value":"9000415212742"},{"@type":"NRID","@value":"9000263064192"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kotataku"}],"foaf:name":[{"@value":"Takuya Kotani"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869951792256","@type":"Researcher","foaf:name":[{"@value":"Ryota 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Makino"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658653249154","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10442922"},{"@type":"NRID","@value":"1000010442922"},{"@type":"NRID","@value":"9000014161887"},{"@type":"NRID","@value":"9000019021153"},{"@type":"NRID","@value":"9000003885769"},{"@type":"NRID","@value":"9000003879994"},{"@type":"NRID","@value":"9000006741428"},{"@type":"NRID","@value":"9000309574129"},{"@type":"NRID","@value":"9000014683889"},{"@type":"NRID","@value":"9000399258789"},{"@type":"NRID","@value":"9000010245804"},{"@type":"NRID","@value":"9000237808065"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/masaii"}],"foaf:name":[{"@value":"Masaaki Ii"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20452322"}],"prism:publicationName":[{"@value":"Scientific Reports"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2017-11-03","prism:volume":"7","prism:number":"1","prism:startingPage":"14608"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41598-017-15022-3"},{"@id":"https://www.nature.com/articles/s41598-017-15022-3.pdf"}],"createdAt":"2017-10-30","modifiedAt":"2025-06-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Inflammation","dc:title":"Inflammation"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages","dc:title":"Macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=Stem%20Cells","dc:title":"Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=T-Lymphocytes","dc:title":"T-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis","dc:title":"Apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=Fibrosis","dc:title":"Fibrosis"},{"@id":"https://cir.nii.ac.jp/all?q=Survival%20Analysis","dc:title":"Survival Analysis"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Bleomycin","dc:title":"Bleomycin"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Adipocytes","dc:title":"Adipocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Administration,%20Intravenous","dc:title":"Administration, 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