{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360846641788265216.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/srep24171"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/srep24171.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/srep24171"}},{"identifier":{"@type":"PMID","@value":"27053385"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Mouse Sox17 haploinsufficiency leads to female subfertility due to impaired implantation"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Embryonic implantation comprises a dynamic and complicated series of events, which takes place only when the maternal uterine endometrium is in a receptive state. Blastocysts reaching the uterus communicate with the uterine endometrium to implant within a narrow time window. Interplay among various signalling molecules and transcription factors under the control of ovarian hormones is necessary for successful establishment of pregnancy. However, the molecular mechanisms that allow embryonic implantation in the receptive endometrium are still largely unknown. Here, we show that Sry-related HMG box gene-17 (<jats:italic>Sox17</jats:italic>) heterozygous mutant female mice exhibit subfertility due to implantation failure. Sox17 was expressed in the oviduct, uterine luminal epithelium, and blood vessels. <jats:italic>Sox17</jats:italic> heterozygosity caused no appreciable defects in ovulation, fertilisation, blastocyst formation, and gross morphology of the oviduct and uterus. Another group F Sox transcription factor, Sox7, was also expressed in the uterine luminal and glandular epithelium relatively weakly. Despite uterine Sox7 expression, a significant reduction in the number of implantation sites was observed in <jats:italic>Sox17</jats:italic> heterozygous mutant females due to haploinsufficiency. Our findings revealed a novel role of Sox17 in uterine receptivity to embryo implantation.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380566395004330373","@type":"Researcher","foaf:name":[{"@value":"Hitomi Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566395004330375","@type":"Researcher","foaf:name":[{"@value":"Philippe Naquet"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751138209792","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30260326"},{"@type":"NRID","@value":"1000030260326"},{"@type":"NRID","@value":"9000000810924"},{"@type":"NRID","@value":"9000253282317"},{"@type":"NRID","@value":"9000009971527"},{"@type":"NRID","@value":"9000415337645"},{"@type":"NRID","@value":"9000415338236"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0123258"}],"foaf:name":[{"@value":"Yoshiakira Kanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566395004330374","@type":"Researcher","foaf:name":[{"@value":"Masami Kanai-Azuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751142776320","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70342839"},{"@type":"NRID","@value":"1000070342839"},{"@type":"NRID","@value":"9000008006510"},{"@type":"NRID","@value":"9000317165883"},{"@type":"NRID","@value":"9000414071109"},{"@type":"NRID","@value":"9000018549443"},{"@type":"NRID","@value":"9000364703943"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ravennayh"}],"foaf:name":[{"@value":"Yoshikazu Hirate"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566395004330370","@type":"Researcher","foaf:name":[{"@value":"Hinako M. Takase"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566395004330368","@type":"Researcher","foaf:name":[{"@value":"Miyuri Kawasumi"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282681406616070","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000292182044"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/higarashi"}],"foaf:name":[{"@value":"Hitomi Igarashi"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1891429165984905600","@type":"Researcher","foaf:name":[{"@value":"The University of Tokyo (UTokyo)"}]},{"@id":"https://cir.nii.ac.jp/crid/1890865117875023617","@type":"Researcher","foaf:name":[{"@value":"Centre d'Immunologie de Marseille - Luminy (CIML) ; Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)"}]},{"@id":"https://cir.nii.ac.jp/crid/1891429165984905601","@type":"Researcher","foaf:name":[{"@value":"Tokyo Medical and Dental University [Japan] (TMDU)"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20452322"}],"prism:publicationName":[{"@value":"Scientific Reports"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2016-04-07","prism:volume":"6","prism:number":"1","prism:startingPage":"24171"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/srep24171.pdf"},{"@id":"https://www.nature.com/articles/srep24171"}],"createdAt":"2016-04-07","modifiedAt":"2023-01-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Blotting,%20Western","dc:title":"Blotting, Western"},{"@id":"https://cir.nii.ac.jp/all?q=Green%20Fluorescent%20Proteins","dc:title":"Green Fluorescent Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Embryonic%20Development","dc:title":"Embryonic Development"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Transgenic","dc:title":"Mice, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=Haploinsufficiency","dc:title":"Haploinsufficiency"},{"@id":"https://cir.nii.ac.jp/all?q=Oviducts","dc:title":"Oviducts"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Epithelium","dc:title":"Epithelium"},{"@id":"https://cir.nii.ac.jp/all?q=HMGB%20Proteins","dc:title":"HMGB Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=SOXF%20Transcription%20Factors","dc:title":"SOXF Transcription Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Embryo%20Implantation","dc:title":"Embryo Implantation"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Microscopy,%20Confocal","dc:title":"Microscopy, Confocal"},{"@id":"https://cir.nii.ac.jp/all?q=Reverse%20Transcriptase%20Polymerase%20Chain%20Reaction","dc:title":"Reverse Transcriptase Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Uterus","dc:title":"Uterus"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Developmental","dc:title":"Gene Expression Regulation, Developmental"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Blastocyst","dc:title":"Blastocyst"},{"@id":"https://cir.nii.ac.jp/all?q=%5BSDV.IMM%5DLife%20Sciences%20%5Bq-bio%5D/Immunology","dc:title":"[SDV.IMM]Life Sciences [q-bio]/Immunology"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Infertility,%20Female","dc:title":"Infertility, Female"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781830572672","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H04282"},{"@type":"JGN","@value":"JP15H04282"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04282/"}],"notation":[{"@language":"ja","@value":"Sox17へテロ不全マウスを用いた着床メカニズムの解明"},{"@language":"en","@value":"Analysis of implantaion process by using Sox17 heterozygous mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782191965056","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24228005"},{"@type":"JGN","@value":"JP24228005"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24228005/"}],"notation":[{"@language":"ja","@value":"胆嚢・胆管の形態形成・再生能と先天性疾患の分子機構の解明"},{"@language":"en","@value":"Morphogenesis, regeneration and congenital disease in gallbladder and bile duct system in mammals"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257211805312","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25112001"},{"@type":"JGN","@value":"JP25112001"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-25112001/"}],"notation":[{"@language":"ja","@value":"生殖細胞のエピゲノムダイナミクスとその制御"},{"@language":"en","@value":"Regulation of epigenome dynamics and regulation in germ cells"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232558418944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235994179456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sox17-Mediated Maintenance of Fetal Intra-Aortic 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