Mouse Sox17 haploinsufficiency leads to female subfertility due to impaired implantation

DOI PDF Web Site PubMed 被引用文献9件 参考文献38件 オープンアクセス

書誌事項

公開日
2016-04-07
資源種別
journal article
権利情報
  • https://creativecommons.org/licenses/by/4.0
  • https://creativecommons.org/licenses/by/4.0
DOI
  • 10.1038/srep24171
公開者
Springer Science and Business Media LLC

説明

<jats:title>Abstract</jats:title><jats:p>Embryonic implantation comprises a dynamic and complicated series of events, which takes place only when the maternal uterine endometrium is in a receptive state. Blastocysts reaching the uterus communicate with the uterine endometrium to implant within a narrow time window. Interplay among various signalling molecules and transcription factors under the control of ovarian hormones is necessary for successful establishment of pregnancy. However, the molecular mechanisms that allow embryonic implantation in the receptive endometrium are still largely unknown. Here, we show that Sry-related HMG box gene-17 (<jats:italic>Sox17</jats:italic>) heterozygous mutant female mice exhibit subfertility due to implantation failure. Sox17 was expressed in the oviduct, uterine luminal epithelium, and blood vessels. <jats:italic>Sox17</jats:italic> heterozygosity caused no appreciable defects in ovulation, fertilisation, blastocyst formation, and gross morphology of the oviduct and uterus. Another group F Sox transcription factor, Sox7, was also expressed in the uterine luminal and glandular epithelium relatively weakly. Despite uterine Sox7 expression, a significant reduction in the number of implantation sites was observed in <jats:italic>Sox17</jats:italic> heterozygous mutant females due to haploinsufficiency. Our findings revealed a novel role of Sox17 in uterine receptivity to embryo implantation.</jats:p>

収録刊行物

  • Scientific Reports

    Scientific Reports 6 (1), 24171-, 2016-04-07

    Springer Science and Business Media LLC

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