- Integration of CiNii Books functions for fiscal year 2025 has completed
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- 【Updated on November 26, 2025】Regarding the recording of “Research Data” and “Evidence Data”
- Incorporated Jxiv preprints from JaLC and adding coverage from NDL Search
Molecular Network Associated with MITF in Skin Melanoma Development and Progression
-
- Ichiro Yajima
- Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
-
- Mayuko Y. Kumasaka
- Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
-
- Nguyen Dinh Thang
- Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
-
- Yuji Goto
- Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
-
- Kozue Takeda
- Unit of Immunology, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
-
- Machiko Iida
- Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
-
- Nobutaka Ohgami
- Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
-
- Yoshiyuki Kawamoto
- Unit of Immunology, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
-
- Osamu Yamanoshita
- Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
-
- Keiko Furukawa
- Health Science Hills, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
-
- Haruka Tamura
- Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
-
- Masashi Kato
- Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, Japan
Bibliographic Information
- Published
- 2011
- Resource Type
- journal article
- Rights Information
-
- http://creativecommons.org/licenses/by/3.0/
- DOI
-
- 10.1155/2011/730170
- Publisher
- Hindawi Limited
Search this article
Description
<jats:p>Various environmental and genetic factors affect the development and progression of skin cancers including melanoma. Melanoma development is initially triggered by environmental factors including ultraviolet (UV) light, and then genetic/epigenetic alterations occur in skin melanocytes. These first triggers alter the conditions of numerous genes and proteins, and they induce and/or reduce gene expression and activate and/or repress protein stability and activity, resulting in melanoma progression.<jats:italic>Microphthalmia-associated transcription factor</jats:italic>(<jats:italic>MITF</jats:italic>) is a master regulator gene of melanocyte development and differentiation and is also associated with melanoma development and progression. To find better approaches to molecular-based therapies for patients, understanding MITF function in skin melanoma development and progression is important. Here, we review the molecular networks associated with MITF in skin melanoma development and progression.</jats:p>
Journal
-
- Journal of Skin Cancer
-
Journal of Skin Cancer 2011 1-7, 2011
Hindawi Limited
